Measurement of plasma metabolites of (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman primates

Nuclear Medicine and Biology

Volumn 28, Issue 1, 2001, Pages 91-96

  Zoghbi, Sami S ^a   Tamagnan, Gilles ^b   Fujita, Masahiro ^b   Baldwin, Ronald M ^b   Al Tikriti, Mohammed S ^b   Amici, Louis ^b   Seibyl, John P ^a   Innis, Robert B ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

(S) 5 123I Iodo 3 (2 azetidinylmethoxy) pyridine; 5 IA 85380; In vivo metabolism; Nicotinic acetylcholine receptor; Pharmacokinetics; 123I 5 IA 85380

Indexed keywords

3 (2 AZETIDINYLMETHOXY)PYRIDINE; 5 IODO 3 (2 AZETIDINYLMETHOXY)PYRIDINE; ACETONITRILE; ENZYME INHIBITOR; IODINE 123; NICOTINIC RECEPTOR; RADIOLIGAND; SODIUM AZIDE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ISOTOPE LABELING; METABOLISM; METABOLITE; MONKEY; NONHUMAN; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THYROID GLAND; TOBACCO DEPENDENCE;

ANIMALS; AZETIDINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ENZYME INHIBITORS; FEMALE; PAPIO; PYRIDINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, NICOTINIC; TISSUE DISTRIBUTION;

EID: 0035137439     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00188-8     Document Type: Article

References (11)

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11. 123I]5-I-A-85380 SPECT