Measurement of α4β2 nicotinic acetylcholine receptors with [123I]5-I-A-85380 SPECT

Journal of Nuclear Medicine

Volumn 41, Issue 9, 2000, Pages 1552-1560

  Fujita, M ^a   Tamagnan, G ^a   Zoghbi, S S ^a   Al Tikriti, M S ^a   Baldwin, R M ^a   Seibyl, J P ^a   Innis, R B ^a  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

3 2(S) 2 azetidinylmethoxy pyridine; Compartment analysis; Equilibrium analysis; Nicotinic receptors; SPECT

Indexed keywords

5 IODO 3 (2 AZETIDINYLMETHOXY)PYRIDINE I 123; IODINE 123; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; RADIOISOTOPE; TRACER; UNCLASSIFIED DRUG; 3 (2 AZETIDINYLMETHOXY)PYRIDINE; ALKALOID; AZETIDINE DERIVATIVE; AZOCINE DERIVATIVE; CYTISINE; DIAGNOSTIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; QUINOLIZINE DERIVATIVE; RADIOACTIVE IODINE;

ANIMAL TISSUE; ARTICLE; BABOON; BRAIN; DRUG STRUCTURE; FEMALE; IMAGE ANALYSIS; ISOTOPE LABELING; KINETICS; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RECEPTOR DENSITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; BINDING COMPETITION; CEREBELLUM; IMAGE PROCESSING; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PAPIO; REGRESSION ANALYSIS; SCINTISCANNING; THALAMUS;

ALKALOIDS; ANIMALS; AZETIDINES; AZOCINES; BINDING, COMPETITIVE; BRAIN; CEREBELLUM; IMAGE PROCESSING, COMPUTER-ASSISTED; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; KINETICS; LEAST-SQUARES ANALYSIS; MAGNETIC RESONANCE IMAGING; PAPIO; QUINOLIZINES; RECEPTORS, NICOTINIC; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0033623405     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Nicotinic cholinergic receptor binding sites in brain: Regulation in vivo
2. Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies
3. Alzheimer's disease: A disorder of cortical cholinergic innervation
4. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia
5. Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease
6. Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity
7. 11C]nicotine in the human brain: Difficulties in visualizing specific receptor binding in vivo
8. Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons
9. Distribution of nicotinic receptors in cynomolgus monkey brain and ganglia: Localization of alpha 3 subunit mRNA, alpha-bungarotoxin and nicotine binding sites
10. Fluorine-18-FPH for PET imaging of nicotinic acetylcholine receptors
11. 11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors
12. Synthesis of a radioiodinated analogue of epibatidine: (+/-)-exo-2-(2-iodo-5-pyridyl)-7-azabicyclo[2.2.1]-heptane for in vitro and in vivo studies of nicotinic acetylcholine receptors
13. (+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors
14. A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand
15. 18F]fluoro-A-85380
16. 123I]iodo-A-85380 using single photon emission computed tomography
17. 5-[I-125/123]iodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors
18. 125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand
19. Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon
20. 18F]fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors
21. 125I]-alphabungarotoxin
22. 3H]nicotine binding sites in the rat brain
23. Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system
24. Kinetic modeling of nicotinic acetylcholine receptor ligand, [CII]A-84543 in baboon PET study
25. Noninvasive quantification of dopamine D2 receptors with iodine-123-IBF SPECT
26. Simplified reference tissue model for PET receptor studies
27. 123I]β-CIT) in nonhuman primates: Pharmacokinetics, biodistribution, and SPECT brain imaging coregistered with MRI
28. 123I]iomazenil in human and nonhuman primates
29. Metabolism of 5-[I-123]-iodo-3-(2(3)-azetidinylmethoxy)pyridine, a nicotinic acetylcholine receptor imaging agent, in non-human primates
30. Evaluation of ultrafiltration for the free fraction determination of single photon emission computed tomography (SPECT) tracers: β-CIT, IBF, and iomazenil
31. Accurate three dimensional registration of CT, PET, and/or MR images of the brain
32. Anatomical atlas of the baboon's brain in the orbito-meatal plane used in experimental positron emission tomography
33. 123I]iomazenil binding to benzodiazepine receptors in nonhuman primates. I. Kinetic modeling of single bolus experiments
34. JAVA tools quantitative post-processing of brain PET data
35. Parameter estimation in positron emission tomography
36. Effects of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG model with and without a vascular compartment: Studies in human brain tumors with PET
37. 11C-methyl]-(-)cocaine PET studies in human subjects
38. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat
39. Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain