Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A- 85380)

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 4, 1998, Pages 309-318

  Horti, Andrew G ^a   Koren, Andrei O ^a   Ravert, Hayden T ^b   Musachio, John L ^b   Mathews, William B ^b   London, Edythe D ^a   Dannals, Robert F ^b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

18F; A 85380; Acetylcholine; Fluorination; Halogen exchange; Nicotinic receptors; Positron emission tomography; Radiotracer

Indexed keywords

FLUORINATION; HALOGENATION; PYRIDINE; SYNTHESIS (CHEMICAL);

18F; A-85380; ACETYLCHOLINE; ACETYLCHOLINE RECEPTOR; HALOGEN EXCHANGE; NICOTINIC ACETYLCHOLINE; NICOTINIC RECEPTOR; PYRIDINE-2; RADIOCHEMICAL SYNTHESIS; RADIOTRACER;

POSITRON EMISSION TOMOGRAPHY;

2 FLUORO 3 (AZETIDINYLMETHOXY)PYRIDINE F 18; 2 IODO 3 [(1 TERT BUTOXYCARBONYLAZETIDINYL)METHOXY]PYRIDINE F 18; FLUORINE 18; NICOTINIC RECEPTOR; TRACER; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FLUORINATION;

EOS;

EID: 0031967176     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199804)41:4<309::AID-JLCR78>3.0.CO;2-I     Document Type: Article

References (23)

1. Decker M.W., Brioni J.D., Bannon A.W., Arneric S.P. - Life. Sci 56: 545 (1995)
2. Flicker D.R.L., Watkins D.L., Fisher S.K., Bartus R.T. - Pharmacol. Biochem. and Behav. 18: 973 (1983)
3. Irle E., Markowitsch H.J. - Ann. Neurol. 14: 1025 (1985)
4. Levin E.D., Rose J.E. - Ann. N.Y. Acad. Sci. 757: 245 (1995)
5. Whitehouse P.J., Martino A.M., Antuono P.G., Lowenstein P.R., Coyle J.T., Price D.L., Kellar K.J. - Brain. Res. 211: 146 (1986)
6. London E.D., Ball M.J., Waller S.B. - Neurochem. Res. 14: 745 (1989)
7. Henningfield J.E., Woodson P.P. - J .Subst.Abuse 1: 301 (1989)
8. Maziere M., Berger G., Masse R., Phimmer D. and Comar D. - In Electrophysiological Effects of Nicotine. Remond, A.; Izard, C., Eds.; Elsevier: Amsterdam, pp 31-47(1979)
9. Nyback H., Nordberg A., Langstrom B., Halldin C., Ahlin A., Swahn C.G., Sedvall G. - Progr. Brain Res. 79: 313 (1989)
10. Horti A., Ravert H.T., London E.D., Dannals R.F. - J.Labelled.Compds.Radiopharm. 38: 355 (1996)
11. Horti A., Scheffel U., Ravert H.T., Finley P., London E.D., Dannals R.F. - J. Nucl. Med. 37: 11P (1996)
12. Horti A., Scheffel U., Stathis M., Finley P., Ravert H.T., London E.D., Dannals R.F. -J. Nucl. Med. 38: 1260 (1997)
13. Villemagne V.L., Horti A., Scheffel U., Ravert H.T., Finley P., London E.D., Dannals R.F. - J. Nucl. Med. 37: 11P (1996)
14. Villemagne V.L., Horti A., Scheffel U., Ravert H.T., Finley P., Clough D.J., London E.D., Wagner H.N., Dannals R.F. - J. Nucl. Med. 38:1737 (1997)
15. Ding Y-S., Gatley S.J., Fowler J.S., Volkow N.D., Aggarwal D., Logan J., Dewey S.L., Liang F., Carroll F.I., Kuhar M.J. - Synapse 24: 403 (1996)
16. Horti A.G., Scheffel U., Kimes A.S., Musachio J.L., Ravert H.T., Mathews W.B., Zhan Y., Finley P.A., London E.D., Dannals R.F. - J.Med.Chem. submitted for publication
17. Molina P., Ding Y.-S., Carrol F.I., Liang F., Volkow N., Kuhar M., Pappas N., King P., Abumrad N., Fowler J.S. - J. Nucl. Med. 38: 287P (1997)
18. Patt J.T., Spang J.E., Westera G., Schubiger P.A. - XIIth International Symposium on Radiopharmaceutical Chemistry, Uppsala, Sweden, June 15-19, 1997, pp.528-530
19. Abreo M.A., Lin N.-H., Garvey D.S., Gunn D.E., Hettinger A.-M, Wasicak J.T., Pavlik P.A., Martin Y.C., Donnelly-Roberts D.L., Anderson D.J., Sullivan J.P., Williams M., Arneric S.P., Holladay M.W. - J.Med.Chem. 39: 817 (1996)
20. Pauly J.R., Anderson D.J., Sullivan J.P. - Soc.Neurosci. Abstr., Vol.22, Part 2, p. 1264 (1996)
21. Kassiou M, Ravert H.T., Mathews W.B., Musachio J.L., London E.D., Dannals R.F. - J.Labelled Compds.Radiopharm. 34: 425 (1997)
22. Kassiou M., Scheffel U.A., Ravert H.T., Mathews W.B., Musachio J.L., London E.D., Dannals R.F. J. Nucl. Med. 38: 65 P (1997)
23. Personal communication, Alexey Mukhin, M.D., PhD, Intramural Research Program, NIDA, Baltimore, MD.