Mapping nicotinic acetylcholine receptors with PET

Synapse

Volumn 24, Issue 4, 1996, Pages 403-407

  Ding, Yu Shin ^a   Gatley, S John ^a   Fowler, Joanna S ^a   Volkow, Nora D ^a   Aggarwal, Deepak ^a   Logan, Jean ^a   Dewey, Stephen L ^a   Liang, Feng ^b   Carroll, F Ivy ^b   Kuhar, Michael J ^c  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b RTI INTERNATIONAL   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

Brain; Epibatidine; Fluorine 18; Nicotinic acetylcholine receptors; Positron emission tomography; Thalamus

Indexed keywords

EPIBATIDINE; FLUORINE 18; NICOTINIC RECEPTOR; RADIOLIGAND;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BABOON; BRAIN MAPPING; DRUG SYNTHESIS; DRUG UPTAKE; IMAGE ANALYSIS; MALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; BRAIN MAPPING; FEMALE; PAPIO; RECEPTORS, NICOTINIC; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 10544241544     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199612)24:4<403::AID-SYN8>3.0.CO;2-H     Document Type: Article

References (24)

1. 18F-fluorination reaction (abstract). J. Label. Cmpds. Radiopharm., 35:562-563.
2. Badio, B., and Daly, J.W. (1994) Epibatidine, a potent analgetic and nicotinic agonist. Mol. Pharmacol., 45:563-569.
3. 3H]mecamylamine binding to rat brain membranes. Biochem. Pharmacol., 40:2105-2110.
4. Bonhaus, D.W., Bley, K.R., Broka, C.A., Fontana, D.J., Leung, L., Lewis, R., Shieh, A., and Wong, E.H.F. (1995) Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine. J. Pharmacol. Exp. Ther., 272:1199-1203.
5. Clarke, P.S., Pert, C.B., and Pert, A. (1984) Autoradiographic distribution of nicotine receptors in rat brain. Brain Res., 323:390-395.
6. Damaj, M.I., Creasy, K.R., Grove, A.D., Rosecrans, J.A., and Martin, B.R. (1994) Pharmacological effects of epibatidine optical enantiomers. Brain Res., 664:34-40.
7. 11C-methyl]benztropine. Synapse, 5:213-223.
8. 11C-raclopride and positron emission tomography. J. Neurosci., 12:3773-3780.
9. Ding, Y.-S., Fowler, J.S., Volkow, N.D., Logan, J., Gatley, S.J., and Sugano, Y. (1995) Carbon-11-d-threo-methylphenidate binding to dopamine transporter in baboon brain. J. Nucl. Med., 36:2298-2305.
10. Domino, E.F., ed. (1995) Brain Imaging of Nicotine and Tobacco Smoking. NPP Books, Ann Arbor, Michigan.
11. 18F]fluoro-5-pyridyl)-7-azabicyclo[2.2.1]heptane. J. Label. Cmpds. Radiopharm., 38:355-365.
12. Horti, A., Scheffel, U., Dannals, R.F., Stathis, M., Finley, P.A., Ravert, H.T., and London, E.D. (1996b) [18F] (±)-exo-2-(2-fluoro-5-pyridyl)-7-azabicyclo[2.2.1]heptane, a radioligand for in vivo labeling and imaging of central nicotinic acetylcholine receptors (abstract). J. Nucl. Med., 37:11P.
13. 11C-methyl](-)-cocaine PET studies in human subjects. J. Cereb. Blood Flow Metab., 10:740-747.
14. 11C: Synthesis and distribution kinetics in animals. Eur. J. Nucl. Med., 1:255-258.
15. 11C-nicotine in the brains of rhesus monkey - An attempt to study nicotinic receptors in vivo. J. Neural Transm., 1:195-205.
16. 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography. J. Neural Transm., 2:215-224.
17. Nyback, H., Nordberg, A., Langstrom, B., Halldin, C., Hartvig, P., Ahlin, A., Swan, C.-G., and Sedvall, G. (1989) Attempts to visualize nicotinic receptors in the brain of monkey and man by positron emission tomography. Prog. Brain Res., 79:313-319.
18. 11C]nicotine in the human brain: Difficulties in visualizing specific receptor binding in vivo. Psychopharmacology (Berlin), 115:31-36.
19. Qian, C., Li, T., Shen, T.Y., Libertine-Garahan, L., Eckman, J., Biftu, T., and Ip, S. (1993) Epibatidine is a nicotinic analgesic. Eur. J. Pharmacol., 250:13-14.
20. Scheffel, U., Taylor, G.F., Kepler, J.A., Carroll, F.I., and Kuhar, M.J. (1995) In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine. Neuroreport, 6:2483-2488.
21. Spande, T.F., Garraffo, H.M., Edwards, M.W., Yeh, H.J.C., Pannell, L., and Daly, J.W. (1992) Epibatidine: A novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran Poison Frog. J. Am. Chem. Soc., 114:3475-3478.
22. Sullivan, J.P., Decker, M.W., Brioni, J.D., Donnelly-Roberts, D., Anderson, D.J., Bannon, A.W., Kang, C.-H., Adams, P., Piattoni-Kaplan, M., Buckley, M.J., Gopalakrishnan, M., Williams, M., and Arneric, S.P. (1994) (±)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther., 271:624-631.
23. Snyder, S., and Yamamura, H.I. (1977) Antidepressants and the muscarinic acetylcholine receptor. Arch. Gen. Psychiatry, 34:236-239.
24. Villemagne, V.L., Horti, A., Scheffel, U., Ravert, H.T., Finley, P.A., London, E.D., and Dannals, R.F. (1996) Imaging nicotinic acetylcholine receptors in baboon brain by PET (abstract). J. Nucl. Med., 37:11P.