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Volumn 12, Issue 21, 2003, Pages 2827-2836

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; HUNTINGTIN; LENTIVIRUS VECTOR; MOLECULAR MARKER; MUTANT PROTEIN; PHOSPHOPROTEIN DARPP 32; TETRACYCLINE; TRANSACTIVATOR PROTEIN;

EID: 0242609127     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg305     Document Type: Article
Times cited : (71)

References (46)
  • 2
    • 0036720019 scopus 로고    scopus 로고
    • Mouse and fly models of neurodegeneration
    • Zoghbi, H. and Botas, J. (2002) Mouse and fly models of neurodegeneration. Trends Genet., 18, 463-471.
    • (2002) Trends Genet. , vol.18 , pp. 463-471
    • Zoghbi, H.1    Botas, J.2
  • 6
  • 10
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto, A., Lucas, J.J. and Hen, R. (2000) Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell, 101, 57-66.
    • (2000) Cell , vol.101 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3
  • 12
    • 0033010987 scopus 로고    scopus 로고
    • Recent advances in understanding the pathogenesis of Huntington's disease
    • Reddy, P.H., Williams, M. and Tagle, D.A. (1999) Recent advances in understanding the pathogenesis of Huntington's disease. Trends Neurosci., 22, 248-255.
    • (1999) Trends Neurosci. , vol.22 , pp. 248-255
    • Reddy, P.H.1    Williams, M.2    Tagle, D.A.3
  • 13
    • 0033009587 scopus 로고    scopus 로고
    • Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
    • Hurlbert, M.S., Zhou, W., Wasmeier, C., Kaddis, F.G., Hutton, J.C. and Freed, C.R. (1999) Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes, 48, 649-651.
    • (1999) Diabetes , vol.48 , pp. 649-651
    • Hurlbert, M.S.1    Zhou, W.2    Wasmeier, C.3    Kaddis, F.G.4    Hutton, J.C.5    Freed, C.R.6
  • 14
    • 13644255250 scopus 로고    scopus 로고
    • Intraneural Aggregates, Striatal Dysfunction and Behavioral Deficits Following Lentiviral Overexpression of Mutated Huntingtin in Rats and Non-human Primates
    • ASGT, Washington, DC
    • Déglon, N., Régulier, E., Palfi, S., Bloch, J., Aebischer, P. and Hantraye, P. (2003) Intraneural Aggregates, Striatal Dysfunction and Behavioral Deficits Following Lentiviral Overexpression of Mutated Huntingtin in Rats and Non-human Primates. ASGT, Washington, DC.
    • (2003)
    • Déglon, N.1    Régulier, E.2    Palfi, S.3    Bloch, J.4    Aebischer, P.5    Hantraye, P.6
  • 15
    • 0036580677 scopus 로고    scopus 로고
    • Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length
    • de Almeida, L.P., Ross, C.A., Zala, D., Aebischer, P. and Déglon, N. (2002) Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. J. Neurosci., 22, 3473-3483.
    • (2002) J. Neurosci. , vol.22 , pp. 3473-3483
    • de Almeida, L.P.1    Ross, C.A.2    Zala, D.3    Aebischer, P.4    Déglon, N.5
  • 16
    • 0037421691 scopus 로고    scopus 로고
    • SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity
    • Yoo, S.Y., Pennesi, M.E., Weeber, E.J., Xu, B., Atkinson, R., Chen, S., Armstrong, D.L., Wu, S.M., Sweatt, J.D. and Zoghbi, H.Y. (2003) SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron, 37, 383-401.
    • (2003) Neuron. , vol.37 , pp. 383-401
    • Yoo, S.Y.1    Pennesi, M.E.2    Weeber, E.J.3    Xu, B.4    Atkinson, R.5    Chen, S.6    Armstrong, D.L.7    Wu, S.M.8    Sweatt, J.D.9    Zoghbi, H.Y.10
  • 17
    • 1842868523 scopus 로고    scopus 로고
    • Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease
    • Régulier, E., Pereira de Almeida, L., Sommer, B., Aebischer, P. and Déglon, N. (2002) Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease. Hum. Gene Ther, 13, 1981-1990.
    • (2002) Hum. Gene. Ther. , vol.13 , pp. 1981-1990
    • Régulier, E.1    Pereira de Almeida, L.2    Sommer, B.3    Aebischer, P.4    Déglon, N.5
  • 18
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F.H., Verma, I.M. and Trono, D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science, 272, 263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5    Gage, F.H.6    Verma, I.M.7    Trono, D.8
  • 19
    • 0030819379 scopus 로고    scopus 로고
    • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
    • Zufferey, R., Nagy, D., Mandel, R.J., Naldini, L. and Trono, D. (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol., 15, 871-875,
    • (1997) Nat. Biotechnol. , vol.15 , pp. 871-875
    • Zufferey, R.1    Nagy, D.2    Mandel, R.J.3    Naldini, L.4    Trono, D.5
  • 20
    • 0036216211 scopus 로고    scopus 로고
    • Tetracycline-dependent gene regulation: Combinations of transregulators yield a variety of expression windows
    • 796, 798
    • Knott, A., Garke, K., Urlinger, S., Guthmann, J., Muller, Y., Thellmann, M. and Hillen, W. (2002) Tetracycline-dependent gene regulation: combinations of transregulators yield a variety of expression windows. Biotechniques, 32, 796, 798, 800.
    • (2002) Biotechniques , vol.32 , pp. 800
    • Knott, A.1    Garke, K.2    Urlinger, S.3    Guthmann, J.4    Muller, Y.5    Thellmann, M.6    Hillen, W.7
  • 21
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of trunsgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • Vigna, E., Cavalieri, S., Ailles, L., Geuna, M., Loew, R., Bujard, H. and Naldini, L. (2002) Robust and efficient regulation of trunsgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol. Ther., 5, 252-261.
    • (2002) Mol. Ther. , vol.5 , pp. 252-261
    • Vigna, E.1    Cavalieri, S.2    Ailles, L.3    Geuna, M.4    Loew, R.5    Bujard, H.6    Naldini, L.7
  • 22
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1    Sapp, E.2    Chase, K.O.3    Davies, S.W.4    Bates, G.P.5    Vonsattel, J.P.6    Aronin, N.7
  • 23
    • 0031680014 scopus 로고    scopus 로고
    • A cellular model that recapitulates major pathogenic steps of Huntington's disease
    • Lunkes, A. and Mandel, J.L. (1998) A cellular model that recapitulates major pathogenic steps of Huntington's disease. Hum. Mol. Genet., 7, 1355-1361.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1355-1361
    • Lunkes, A.1    Mandel, J.L.2
  • 24
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou, F., Finkbeiner, S., Devys, D. and Greenberg, M.E. (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell, 95, 55-66.
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3    Greenberg, M.E.4
  • 25
    • 0034426013 scopus 로고    scopus 로고
    • Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
    • Li, H., Li, S.H., Johnston, H., Shelbourne, P.F. and Li, X.J. (2000) Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat. Genet., 25, 385-389.
    • (2000) Nat. Genet. , vol.25 , pp. 385-389
    • Li, H.1    Li, S.H.2    Johnston, H.3    Shelbourne, P.F.4    Li, X.J.5
  • 26
    • 0036671821 scopus 로고    scopus 로고
    • Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
    • Lunkes, A., Lindenberg, K.S., Ben-Haiem, L., Weber, C., Devys, D., Landwehrmeyer, G.B., Mandel, J.L. and Trottier, Y. (2002) Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell, 10, 259-269.
    • (2002) Mol. Cell , vol.10 , pp. 259-269
    • Lunkes, A.1    Lindenberg, K.S.2    Ben-Haiem, L.3    Weber, C.4    Devys, D.5    Landwehrmeyer, G.B.6    Mandel, J.L.7    Trottier, Y.8
  • 28
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen, M., Ona, V.O., Li, M., Ferrante, R.J., Fink, K.B., Zhu, S., Bian, J., Guo, L., Farrell, L.A., Hersch, S.M. et al. (2000) Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat. Med., 6, 797-801.
    • (2000) Nat. Med. , vol.6 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3    Ferrante, R.J.4    Fink, K.B.5    Zhu, S.6    Bian, J.7    Guo, L.8    Farrell, L.A.9    Hersch, S.M.10
  • 30
    • 0034329159 scopus 로고    scopus 로고
    • Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative digease
    • Gusella, J.F. and MacDonald, M.E. (2000) Molecular genetics: unmasking polyglutamine triggers in neurodegenerative digease. Nat. Rev. Neurosci., 1, 109-115.
    • (2000) Nat. Rev. Neurosci. , vol.1 , pp. 109-115
    • Gusella, J.F.1    MacDonald, M.E.2
  • 31
    • 0033953015 scopus 로고    scopus 로고
    • Caspases and neurodegeneration: On the cutting edge of new therapeutic approaches
    • Wellington, C.L. and Hayden, M.R. (2000) Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches. Clin. Genet., 57, 1-10.
    • (2000) Clin. Genet. , vol.57 , pp. 1-10
    • Wellington, C.L.1    Hayden, M.R.2
  • 32
    • 0035940412 scopus 로고    scopus 로고
    • Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
    • Kim, Y.J., Yi, Y., Sapp, E., Wang, Y., Cuiffo, B., Kegel, K.B., Qin, Z.H., Aronin, N. and DiFiglia, M. (2001) Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc. Natl Acad. Sci. USA, 98, 12784-12789.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12784-12789
    • Kim, Y.J.1    Yi, Y.2    Sapp, E.3    Wang, Y.4    Cuiffo, B.5    Kegel, K.B.6    Qin, Z.H.7    Aronin, N.8    DiFiglia, M.9
  • 33
    • 0037096376 scopus 로고    scopus 로고
    • Calpain activation in Huntington's disease
    • Gafni, J. and Ellerby, L.M. (2002) Calpain activation in Huntington's disease. J. Neurosci., 22, 4842-4849.
    • (2002) J. Neurosci. , vol.22 , pp. 4842-4849
    • Gafni, J.1    Ellerby, L.M.2
  • 36
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA, 89, 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 38
    • 0037444445 scopus 로고    scopus 로고
    • Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease
    • Yu, Z.X., Li, S.H., Evans, J., Pillarisetti, A., Li, H. and Li, X.J. (2003) Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J. Neurosci., 23, 2193-2202.
    • (2003) J. Neurosci. , vol.23 , pp. 2193-2202
    • Yu, Z.X.1    Li, S.H.2    Evans, J.3    Pillarisetti, A.4    Li, H.5    Li, X.J.6
  • 39
    • 0035976953 scopus 로고    scopus 로고
    • The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease
    • Chai, Y., Wu, L., Griffin, J.D. and Paulson, H.L. (2001) The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease. J. Biol. Chem., 276, 44889-44897.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44889-44897
    • Chai, Y.1    Wu, L.2    Griffin, J.D.3    Paulson, H.L.4
  • 40
    • 0038701684 scopus 로고    scopus 로고
    • Huntingtin aggregation and toxicity in Huntington's disease
    • Bates, G. (2003) Huntingtin aggregation and toxicity in Huntington's disease. Lancet, 361, 1642-1644.
    • (2003) Lancet , vol.361 , pp. 1642-1644
    • Bates, G.1
  • 41
    • 0036787671 scopus 로고    scopus 로고
    • siRNA-mediated gene silencing in vitro and in vivo
    • Xia, H., Mao, Q., Paulson, H.L. and Davidson, B.L. (2002) siRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol., 20, 1006-1010.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 1006-1010
    • Xia, H.1    Mao, Q.2    Paulson, H.L.3    Davidson, B.L.4
  • 45
    • 0034979217 scopus 로고    scopus 로고
    • Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease
    • de Almeida, L.P., Zala, D., Aebischer, P. and Déglon, N. (2001) Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease. Neurobiol. Dis., 8, 433-446.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 433-446
    • de Almeida, L.P.1    Zala, D.2    Aebischer, P.3    Déglon, N.4
  • 46
    • 0035783942 scopus 로고    scopus 로고
    • Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome
    • Bensadoun, J., Pereira de Almeida, L., Dreano, M., Aebischer, P. and Déglon, N. (2001) Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome. Eur. J. Neurosci., 14, 1-11.
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 1-11
    • Bensadoun, J.1    Pereira de Almeida, L.2    Dreano, M.3    Aebischer, P.4    Déglon, N.5


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