-
1
-
-
0035393427
-
SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein
-
Nakamura, K., Jeong, S.Y., Uchihara, T., Anno, M., Nagashima, K., Nagashima, T., Ikeda, S., Tsuji, S. and Kanazawa, I. (2001) SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum. Mol. Genet., 10, 1441-1448.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1441-1448
-
-
Nakamura, K.1
Jeong, S.Y.2
Uchihara, T.3
Anno, M.4
Nagashima, K.5
Nagashima, T.6
Ikeda, S.7
Tsuji, S.8
Kanazawa, I.9
-
2
-
-
0036720019
-
Mouse and fly models of neurodegeneration
-
Zoghbi, H. and Botas, J. (2002) Mouse and fly models of neurodegeneration. Trends Genet., 18, 463-471.
-
(2002)
Trends Genet.
, vol.18
, pp. 463-471
-
-
Zoghbi, H.1
Botas, J.2
-
3
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini, L.F.-S., Sathasivam, K.F.-S., Seller, M.F.-C., Cozens, B.F.-H., Harper, A.F.-H., Hetherington, C.F.-L., Lawton, M.F.-T., Trottier, Y.F.-L., Lehrach, H.F.-D., Davies, S.W.F.-B. et al. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, 87, 493-506.
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.F.-S.1
Sathasivam, K.F.-S.2
Seller, M.F.-C.3
Cozens, B.F.-H.4
Harper, A.F.-H.5
Hetherington, C.F.-L.6
Lawton, M.F.-T.7
Trottier, Y.F.-L.8
Lehrach, H.F.-D.9
Davies, S.W.F.-B.10
-
4
-
-
0030613177
-
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion
-
White, J.K., Auerbach, W., Duyao, M.P., Vonsattel, J.P., Gusella, J.F., Joyner, A.L. and MacDonald, M.E. (1997) Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat. Genet., 17, 404-410.
-
(1997)
Nat. Genet.
, vol.17
, pp. 404-410
-
-
White, J.K.1
Auerbach, W.2
Duyao, M.P.3
Vonsattel, J.P.4
Gusella, J.F.5
Joyner, A.L.6
MacDonald, M.E.7
-
5
-
-
17344367977
-
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA
-
Reddy, P.H., Williams, M., Charles, V., Garrett, L., Pike-Buchanan, L., Whetsell, W.O. Jr, Miller, G. and Tagle, D.A. (1998) Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat. Genet., 20, 198-202.
-
(1998)
Nat. Genet.
, vol.20
, pp. 198-202
-
-
Reddy, P.H.1
Williams, M.2
Charles, V.3
Garrett, L.4
Pike-Buchanan, L.5
Whetsell Jr., W.O.6
Miller, G.7
Tagle, D.A.8
-
6
-
-
0033136692
-
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
-
Hodgson, J.G., Agopyan, N., Gutekunst, C.A., Leavitt, B.R., LePiane, F., Singaraja, R., Smith, D.J., Bissada, N., McCutcheon, K., Nasir, J. et al. (1999) A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal. neurodegeneration. Neuron, 23, 181-192.
-
(1999)
Neuron.
, vol.23
, pp. 181-192
-
-
Hodgson, J.G.1
Agopyan, N.2
Gutekunst, C.A.3
Leavitt, B.R.4
LePiane, F.5
Singaraja, R.6
Smith, D.J.7
Bissada, N.8
McCutcheon, K.9
Nasir, J.10
-
7
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling, G., Becher, M.W., Sharp, A.H., Jinnah, H.A., Duan, K., Kotzuk, J.A., Slunt, H.H., Ratovitski, T., Cooper, J.K., Jenkins, N.A. et al. (1999) Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum. Mol. Genet., 8, 397-407.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
Slunt, H.H.7
Ratovitski, T.8
Cooper, J.K.9
Jenkins, N.A.10
-
8
-
-
0032949459
-
A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice
-
Shelbourne, P.F., Killeen, N., Hevner, R.F., Johnston, H.M., Tecott, L., Lewandoski, M., Ennis, M., Ramirez, L., Li, Z., Iannicola, C. et al. (1999) A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Hum. Mol. Genet., 8, 763-774.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 763-774
-
-
Shelbourne, P.F.1
Killeen, N.2
Hevner, R.F.3
Johnston, H.M.4
Tecott, L.5
Lewandoski, M.6
Ennis, M.7
Ramirez, L.8
Li, Z.9
Iannicola, C.10
-
9
-
-
0032938295
-
Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse
-
Wheeler, V.C., Auerbach, W., White, J.K., Srinidhi, J., Auerbach, A., Ryan, A., Duyao, M.P., Vrbanac, V., Weaver, M., Gusella, J.F. et al. (1999) Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse. Hum. Mol. Genet., 8, 115-122.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 115-122
-
-
Wheeler, V.C.1
Auerbach, W.2
White, J.K.3
Srinidhi, J.4
Auerbach, A.5
Ryan, A.6
Duyao, M.P.7
Vrbanac, V.8
Weaver, M.9
Gusella, J.F.10
-
10
-
-
0034737299
-
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
-
Yamamoto, A., Lucas, J.J. and Hen, R. (2000) Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell, 101, 57-66.
-
(2000)
Cell
, vol.101
, pp. 57-66
-
-
Yamamoto, A.1
Lucas, J.J.2
Hen, R.3
-
11
-
-
0035862896
-
Neurological abnormalities in a knock-in mouse model of Huntington's disease
-
Lin, C.H., Tallaksen-Greene, S., Chien, W.M., Cearley, J.A., Jackson, W.S., Crouse, A.B., Ren, S., Li, X.J., Albin, R.L. and Detloff, P.J. (2001) Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum. Mol. Genet., 10, 137-144.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 137-144
-
-
Lin, C.H.1
Tallaksen-Greene, S.2
Chien, W.M.3
Cearley, J.A.4
Jackson, W.S.5
Crouse, A.B.6
Ren, S.7
Li, X.J.8
Albin, R.L.9
Detloff, P.J.10
-
12
-
-
0033010987
-
Recent advances in understanding the pathogenesis of Huntington's disease
-
Reddy, P.H., Williams, M. and Tagle, D.A. (1999) Recent advances in understanding the pathogenesis of Huntington's disease. Trends Neurosci., 22, 248-255.
-
(1999)
Trends Neurosci.
, vol.22
, pp. 248-255
-
-
Reddy, P.H.1
Williams, M.2
Tagle, D.A.3
-
13
-
-
0033009587
-
Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
-
Hurlbert, M.S., Zhou, W., Wasmeier, C., Kaddis, F.G., Hutton, J.C. and Freed, C.R. (1999) Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes, 48, 649-651.
-
(1999)
Diabetes
, vol.48
, pp. 649-651
-
-
Hurlbert, M.S.1
Zhou, W.2
Wasmeier, C.3
Kaddis, F.G.4
Hutton, J.C.5
Freed, C.R.6
-
14
-
-
13644255250
-
Intraneural Aggregates, Striatal Dysfunction and Behavioral Deficits Following Lentiviral Overexpression of Mutated Huntingtin in Rats and Non-human Primates
-
ASGT, Washington, DC
-
Déglon, N., Régulier, E., Palfi, S., Bloch, J., Aebischer, P. and Hantraye, P. (2003) Intraneural Aggregates, Striatal Dysfunction and Behavioral Deficits Following Lentiviral Overexpression of Mutated Huntingtin in Rats and Non-human Primates. ASGT, Washington, DC.
-
(2003)
-
-
Déglon, N.1
Régulier, E.2
Palfi, S.3
Bloch, J.4
Aebischer, P.5
Hantraye, P.6
-
15
-
-
0036580677
-
Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length
-
de Almeida, L.P., Ross, C.A., Zala, D., Aebischer, P. and Déglon, N. (2002) Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. J. Neurosci., 22, 3473-3483.
-
(2002)
J. Neurosci.
, vol.22
, pp. 3473-3483
-
-
de Almeida, L.P.1
Ross, C.A.2
Zala, D.3
Aebischer, P.4
Déglon, N.5
-
16
-
-
0037421691
-
SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity
-
Yoo, S.Y., Pennesi, M.E., Weeber, E.J., Xu, B., Atkinson, R., Chen, S., Armstrong, D.L., Wu, S.M., Sweatt, J.D. and Zoghbi, H.Y. (2003) SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron, 37, 383-401.
-
(2003)
Neuron.
, vol.37
, pp. 383-401
-
-
Yoo, S.Y.1
Pennesi, M.E.2
Weeber, E.J.3
Xu, B.4
Atkinson, R.5
Chen, S.6
Armstrong, D.L.7
Wu, S.M.8
Sweatt, J.D.9
Zoghbi, H.Y.10
-
17
-
-
1842868523
-
Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease
-
Régulier, E., Pereira de Almeida, L., Sommer, B., Aebischer, P. and Déglon, N. (2002) Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease. Hum. Gene Ther, 13, 1981-1990.
-
(2002)
Hum. Gene. Ther.
, vol.13
, pp. 1981-1990
-
-
Régulier, E.1
Pereira de Almeida, L.2
Sommer, B.3
Aebischer, P.4
Déglon, N.5
-
18
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F.H., Verma, I.M. and Trono, D. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science, 272, 263-267.
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
Blomer, U.2
Gallay, P.3
Ory, D.4
Mulligan, R.5
Gage, F.H.6
Verma, I.M.7
Trono, D.8
-
19
-
-
0030819379
-
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
-
Zufferey, R., Nagy, D., Mandel, R.J., Naldini, L. and Trono, D. (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol., 15, 871-875,
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 871-875
-
-
Zufferey, R.1
Nagy, D.2
Mandel, R.J.3
Naldini, L.4
Trono, D.5
-
20
-
-
0036216211
-
Tetracycline-dependent gene regulation: Combinations of transregulators yield a variety of expression windows
-
796, 798
-
Knott, A., Garke, K., Urlinger, S., Guthmann, J., Muller, Y., Thellmann, M. and Hillen, W. (2002) Tetracycline-dependent gene regulation: combinations of transregulators yield a variety of expression windows. Biotechniques, 32, 796, 798, 800.
-
(2002)
Biotechniques
, vol.32
, pp. 800
-
-
Knott, A.1
Garke, K.2
Urlinger, S.3
Guthmann, J.4
Muller, Y.5
Thellmann, M.6
Hillen, W.7
-
21
-
-
0036193248
-
Robust and efficient regulation of trunsgene expression in vivo by improved tetracycline-dependent lentiviral vectors
-
Vigna, E., Cavalieri, S., Ailles, L., Geuna, M., Loew, R., Bujard, H. and Naldini, L. (2002) Robust and efficient regulation of trunsgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol. Ther., 5, 252-261.
-
(2002)
Mol. Ther.
, vol.5
, pp. 252-261
-
-
Vigna, E.1
Cavalieri, S.2
Ailles, L.3
Geuna, M.4
Loew, R.5
Bujard, H.6
Naldini, L.7
-
22
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
23
-
-
0031680014
-
A cellular model that recapitulates major pathogenic steps of Huntington's disease
-
Lunkes, A. and Mandel, J.L. (1998) A cellular model that recapitulates major pathogenic steps of Huntington's disease. Hum. Mol. Genet., 7, 1355-1361.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1355-1361
-
-
Lunkes, A.1
Mandel, J.L.2
-
24
-
-
0032475931
-
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
-
Saudou, F., Finkbeiner, S., Devys, D. and Greenberg, M.E. (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell, 95, 55-66.
-
(1998)
Cell
, vol.95
, pp. 55-66
-
-
Saudou, F.1
Finkbeiner, S.2
Devys, D.3
Greenberg, M.E.4
-
25
-
-
0034426013
-
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
-
Li, H., Li, S.H., Johnston, H., Shelbourne, P.F. and Li, X.J. (2000) Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat. Genet., 25, 385-389.
-
(2000)
Nat. Genet.
, vol.25
, pp. 385-389
-
-
Li, H.1
Li, S.H.2
Johnston, H.3
Shelbourne, P.F.4
Li, X.J.5
-
26
-
-
0036671821
-
Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
-
Lunkes, A., Lindenberg, K.S., Ben-Haiem, L., Weber, C., Devys, D., Landwehrmeyer, G.B., Mandel, J.L. and Trottier, Y. (2002) Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell, 10, 259-269.
-
(2002)
Mol. Cell
, vol.10
, pp. 259-269
-
-
Lunkes, A.1
Lindenberg, K.S.2
Ben-Haiem, L.3
Weber, C.4
Devys, D.5
Landwehrmeyer, G.B.6
Mandel, J.L.7
Trottier, Y.8
-
27
-
-
0036451321
-
Polyglutamine repeat length-dependent proteolysis of huntingtin
-
Sun, B., Fan, W., Balciunas, A., Cooper, J.K., Bitan, G., Steavenson, S., Denis, P.E., Young, Y., Adler, B., Daugherty, L. et al. (2002) Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiol. Dis., 11, 111-122.
-
(2002)
Neurobiol. Dis.
, vol.11
, pp. 111-122
-
-
Sun, B.1
Fan, W.2
Balciunas, A.3
Cooper, J.K.4
Bitan, G.5
Steavenson, S.6
Denis, P.E.7
Young, Y.8
Adler, B.9
Daugherty, L.10
-
28
-
-
0033912716
-
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
-
Chen, M., Ona, V.O., Li, M., Ferrante, R.J., Fink, K.B., Zhu, S., Bian, J., Guo, L., Farrell, L.A., Hersch, S.M. et al. (2000) Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat. Med., 6, 797-801.
-
(2000)
Nat. Med.
, vol.6
, pp. 797-801
-
-
Chen, M.1
Ona, V.O.2
Li, M.3
Ferrante, R.J.4
Fink, K.B.5
Zhu, S.6
Bian, J.7
Guo, L.8
Farrell, L.A.9
Hersch, S.M.10
-
29
-
-
0034597833
-
Identification of genes that modify ataxin-1-induced neurodegeneration
-
Fernandez-Funez, P., Nino-Rosales, M.L., de Gouyon, B., She, W.C., Luchak, J.M., Martinez, P., Turiegano, E., Benito, J., Capovilla, M., Skinner, P.J. et al. (2000) Identification of genes that modify ataxin-1-induced neurodegeneration. Nature, 408, 101-106.
-
(2000)
Nature
, vol.408
, pp. 101-106
-
-
Fernandez-Funez, P.1
Nino-Rosales, M.L.2
de Gouyon, B.3
She, W.C.4
Luchak, J.M.5
Martinez, P.6
Turiegano, E.7
Benito, J.8
Capovilla, M.9
Skinner, P.J.10
-
30
-
-
0034329159
-
Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative digease
-
Gusella, J.F. and MacDonald, M.E. (2000) Molecular genetics: unmasking polyglutamine triggers in neurodegenerative digease. Nat. Rev. Neurosci., 1, 109-115.
-
(2000)
Nat. Rev. Neurosci.
, vol.1
, pp. 109-115
-
-
Gusella, J.F.1
MacDonald, M.E.2
-
31
-
-
0033953015
-
Caspases and neurodegeneration: On the cutting edge of new therapeutic approaches
-
Wellington, C.L. and Hayden, M.R. (2000) Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches. Clin. Genet., 57, 1-10.
-
(2000)
Clin. Genet.
, vol.57
, pp. 1-10
-
-
Wellington, C.L.1
Hayden, M.R.2
-
32
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
-
Kim, Y.J., Yi, Y., Sapp, E., Wang, Y., Cuiffo, B., Kegel, K.B., Qin, Z.H., Aronin, N. and DiFiglia, M. (2001) Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc. Natl Acad. Sci. USA, 98, 12784-12789.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.H.7
Aronin, N.8
DiFiglia, M.9
-
33
-
-
0037096376
-
Calpain activation in Huntington's disease
-
Gafni, J. and Ellerby, L.M. (2002) Calpain activation in Huntington's disease. J. Neurosci., 22, 4842-4849.
-
(2002)
J. Neurosci.
, vol.22
, pp. 4842-4849
-
-
Gafni, J.1
Ellerby, L.M.2
-
34
-
-
0036314167
-
Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain
-
Toneff, T., Mende-Mueller, L., Wu, Y., Hwang, S.R., Bundey, R., Thompson, L.M., Chesselet, M.F. and Hook, V. (2002) Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain. J. Neurochem., 82, 84-92.
-
(2002)
J. Neurochem.
, vol.82
, pp. 84-92
-
-
Toneff, T.1
Mende-Mueller, L.2
Wu, Y.3
Hwang, S.R.4
Bundey, R.5
Thompson, L.M.6
Chesselet, M.F.7
Hook, V.8
-
35
-
-
0037131263
-
Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons
-
Goffredo, D., Rigamonti, D., Tartari, M., De Micheli, A., Verderio, C., Matteoli, M., Zuccato, C. and Cattaneo, E. (2002) Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons. J. Biol. Chem., 277, 39594-39598.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39594-39598
-
-
Goffredo, D.1
Rigamonti, D.2
Tartari, M.3
De Micheli, A.4
Verderio, C.5
Matteoli, M.6
Zuccato, C.7
Cattaneo, E.8
-
36
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA, 89, 5547-5551.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
37
-
-
0033977265
-
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease
-
Déglon, N., Tseng, J.L., Bensadoun, J.C., Zurn, A.D., Arsenijevic, Y., Pereira de Almeida, L., Zufferey, R., Trono, D. and Aebischer, P. (2000) Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum. Gene Ther., 11, 179-190.
-
(2000)
Hum. Gene Ther.
, vol.11
, pp. 179-190
-
-
Déglon, N.1
Tseng, J.L.2
Bensadoun, J.C.3
Zurn, A.D.4
Arsenijevic, Y.5
Pereira de Almeida, L.6
Zufferey, R.7
Trono, D.8
Aebischer, P.9
-
38
-
-
0037444445
-
Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease
-
Yu, Z.X., Li, S.H., Evans, J., Pillarisetti, A., Li, H. and Li, X.J. (2003) Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J. Neurosci., 23, 2193-2202.
-
(2003)
J. Neurosci.
, vol.23
, pp. 2193-2202
-
-
Yu, Z.X.1
Li, S.H.2
Evans, J.3
Pillarisetti, A.4
Li, H.5
Li, X.J.6
-
39
-
-
0035976953
-
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease
-
Chai, Y., Wu, L., Griffin, J.D. and Paulson, H.L. (2001) The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease. J. Biol. Chem., 276, 44889-44897.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44889-44897
-
-
Chai, Y.1
Wu, L.2
Griffin, J.D.3
Paulson, H.L.4
-
40
-
-
0038701684
-
Huntingtin aggregation and toxicity in Huntington's disease
-
Bates, G. (2003) Huntingtin aggregation and toxicity in Huntington's disease. Lancet, 361, 1642-1644.
-
(2003)
Lancet
, vol.361
, pp. 1642-1644
-
-
Bates, G.1
-
41
-
-
0036787671
-
siRNA-mediated gene silencing in vitro and in vivo
-
Xia, H., Mao, Q., Paulson, H.L. and Davidson, B.L. (2002) siRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol., 20, 1006-1010.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 1006-1010
-
-
Xia, H.1
Mao, Q.2
Paulson, H.L.3
Davidson, B.L.4
-
42
-
-
0036976008
-
Lentiviral-mediated RNA interference
-
Abbas-Terki, T., Blanco-Bose, W., Deglon, N., Pralong, W. and Aebischer, P. (2002) Lentiviral-mediated RNA interference. Hum. Gene Ther., 13, 2197-2201.
-
(2002)
Hum. Gene Ther.
, vol.13
, pp. 2197-2201
-
-
Abbas-Terki, T.1
Blanco-Bose, W.2
Deglon, N.3
Pralong, W.4
Aebischer, P.5
-
43
-
-
0038132996
-
Allele-specific silencing of dominant disease genes
-
Miller, V.M., Xia, H., Marrs, G.L., Gouvion, C.M., Lee, G., Davidson, B.L. and Paulson, H.L. (2003) Allele-specific silencing of dominant disease genes. Proc. Natl Acad. Sci. USA, 100, 7195-7200.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7195-7200
-
-
Miller, V.M.1
Xia, H.2
Marrs, G.L.3
Gouvion, C.M.4
Lee, G.5
Davidson, B.L.6
Paulson, H.L.7
-
44
-
-
0032101287
-
The influence of huntingtin protein size on nuclear localization and cellular toxicity
-
Hackam, A.S., Singaraja, R., Wellington, C.L., Metzler, M., McCutcheon, K., Zhang, T., Kalchman, M. and Hayden, M.R. (1998) The influence of huntingtin protein size on nuclear localization and cellular toxicity. J. Cell Biol., 141, 1097-1105.
-
(1998)
J. Cell Biol.
, vol.141
, pp. 1097-1105
-
-
Hackam, A.S.1
Singaraja, R.2
Wellington, C.L.3
Metzler, M.4
McCutcheon, K.5
Zhang, T.6
Kalchman, M.7
Hayden, M.R.8
-
45
-
-
0034979217
-
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease
-
de Almeida, L.P., Zala, D., Aebischer, P. and Déglon, N. (2001) Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease. Neurobiol. Dis., 8, 433-446.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 433-446
-
-
de Almeida, L.P.1
Zala, D.2
Aebischer, P.3
Déglon, N.4
-
46
-
-
0035783942
-
Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome
-
Bensadoun, J., Pereira de Almeida, L., Dreano, M., Aebischer, P. and Déglon, N. (2001) Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome. Eur. J. Neurosci., 14, 1-11.
-
(2001)
Eur. J. Neurosci.
, vol.14
, pp. 1-11
-
-
Bensadoun, J.1
Pereira de Almeida, L.2
Dreano, M.3
Aebischer, P.4
Déglon, N.5
|