Evolution of shape complementarity and catalytic efficiency from a primordial antibody template

Science

Volumn 286, Issue 5448, 1999, Pages 2345-2348

  Xu, Jian ^a,b   Deng, Qiaolin ^c   Chen, Jiangang ^c   Houk, Kendall N ^c   Bartek, Johannes ^d   Hilvert, Donald ^d   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ACCELRYS INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; PROGESTERONE;

ANTIBODY STRUCTURE; ARTICLE; CATALYSIS; CATALYST; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EVOLUTION; PRIORITY JOURNAL;

ANTIBODIES, CATALYTIC; BINDING SITES, ANTIBODY; CATALYSIS; CHEMISTRY, PHYSICAL; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; HAPTENS; HYDROGEN BONDING; IMMUNOGLOBULIN FAB FRAGMENTS; LIGANDS; MODELS, MOLECULAR; MUTATION; PROGESTERONE; PROTEIN CONFORMATION; SOLUBILITY; TEMPERATURE; TEMPLATES, GENETIC;

BETULACEAE;

EID: 0033579299     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5448.2345     Document Type: Article

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53. Supported by NIH grants CA27489 (I.A.W.) and GM38273 (D.H.) and NSF grant CHE-9616772 (K.N.H.). We thank T. Horton, N. Jiang, and M. Auditor for technical assistance; the staff of SSRL beamline 9-1; R. A. Lerner, A. Heine, and D. J. Edwards for helpful discussions; the referees for helpful comments; N. R. Klinman for advice on germ line gene analysis; and K. Renner for computational assistance.