Effects of substitutions in the binding surface of an antibody on antigen affinity

Protein Engineering

Volumn 11, Issue 1, 1998, Pages 65-74

  Dougan, David A ^a   Malby, Robyn L ^a,b   Gruen, L Clem ^a   Kortt, Alexander A ^a   Hudson, Peter J ^a  

^a CSIRO   (Australia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibody; Antibody antigen interactions; NC10; Neuraminidase; Site directed mutagenesis

Indexed keywords

ANTIBODY; ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; VIRUS SIALIDASE;

AMINO ACID SUBSTITUTION; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BIOSENSOR; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

INFLUENZA VIRUS;

EID: 0031887368     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/11.1.65     Document Type: Article

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