Structural parameterization of the binding enthalpy of small ligands

Proteins: Structure, Function and Genetics

Volumn 49, Issue 2, 2002, Pages 181-190

  Luque, Irene ^a   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Binding energetics; Binding thermodynamics; HIV 1 protease; Isothermal titration calorimetry; Structure based drug design

Indexed keywords

ACETYLSERYLLEUCYLASPARAGINYLPHENYLALANINAMIDE; BETA TRYPSIN; CHAPERONE; DIHYDRODIPICOLINATE REDUCTASE; GLUTAMYLASPARTYLLEUCINAMIDE; HEAT SHOCK PROTEIN 90; INDINAVIR; KYNOSTATIN 272; LEUCINE; LIGAND; NELFINAVIR; OXIDOREDUCTASE; PHENYLALANINE DERIVATIVE; PROTEIN KINASE P60; PROTEINASE; RIBONUCLEASE T1; RITONAVIR; SAQUINAVIR; STREPTAVIDIN; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; DRUG DESIGN; DRUG STRUCTURE; ENERGY; ENTHALPY; ENTROPY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONHUMAN; PARAMETRIC TEST; PREDICTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON TRANSPORT; STATISTICAL ANALYSIS;

ANIMALS; BINDING SITES; DATABASES, PROTEIN; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEINS; PROTONS; SOLVENTS; THERMODYNAMICS; WATER;

BOVINAE; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036836538     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10208     Document Type: Article

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