The immunological evolution of catalysis

Science

Volumn 271, Issue 5252, 1996, Pages 1086-1091

  Patten, Phillip A ^a   Gray, Nathanael S ^a   Yang, Priscilla L ^a   Marks, Cara B ^a   Wedemayer, Gary J ^a   Boniface, J Jay ^b   Stevens, Raymond C ^a   Schultz, Peter G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC ANTIBODY;

ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; EVOLUTION; GENE; GENE EXPRESSION; GENE MUTATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; SOMATIC MUTATION;

EID: 0029991227     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5252.1086     Document Type: Article

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58. We thank M Davis for use of the BlAcore; D. Henner, S. Bass, and B Snedecore (Genentech) for the plasmids pMY-55, -60, and -61; D. King for performing electrospray mass spectrophotometry; Stanford Synchrotron Radiation Laboratory for data collection time and H. Morimoto (National Tritium Labeling Facility) for assistance synthesizing tritiated hapten 3 Supported in part by the National Institutes of Health (RO1-Al24695), the Howard Hughes Medical Institute, a Damon Runyon-Walter Winchell Cancer Research Fund Fellowship (P A.P.), a Howard Hughes Predoctoral Fellowship (P.L Y.), and the Irvington Institute for Medical Research (J.J.B.) The coordinates have been deposited in the Brookhaven Protein Data Bank (PDB, 11GAF).