Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: Crystal structures of abzyme 21D8

Journal of Molecular Biology

Volumn 302, Issue 5, 2000, Pages 1213-1225

  Hotta, Kinya ^a,c   Lange, Holger ^b   Tantillo, Dean J ^b   Houk, K N ^b   Hilvert, Donald ^c   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ETH ZURICH   (Switzerland)

Author keywords

Antibody catalysis; Computational docking; Enzyme evolution; Immune response; Medium effects

Indexed keywords

ANION; ANTIBODY; CARBOXYLASE; CHIMERIC PROTEIN; ENZYME; ESTERASE; HAPTEN; IMMUNOGLOBULIN F(AB) FRAGMENT; ISOXAZOLE DERIVATIVE; SERUM ALBUMIN;

ANTIGEN BINDING; ARTICLE; BINDING SITE; CALCULATION; CATALYSIS; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME STRUCTURE; IMMUNE RESPONSE; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

EID: 0034613026     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4503     Document Type: Article

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