Innate immunity and inflammation: A transcriptional paradigm

Immunologic Research

Volumn 23, Issue 2-3, 2001, Pages 99-109

  Hawiger, J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell Permeable Peptides; Inflammation; Innate Immunity; Lipopolysaccharides; Monocytes and Macrophages; NF B; Nuclear Import; Superantigens; T cells; Transcription Factors

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STRESS RESPONSIVE TRANSCRIPTION FACTOR; SUPERANTIGEN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; CELL MEMBRANE PERMEABILITY; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; INFLAMMATION; LETHAL DOSE; MONONUCLEAR PHAGOCYTE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE ACTIVATION;

EID: 0034984262     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/ir:23:2-3:099     Document Type: Article

References (59)

1. Activators and target genes of Rel/NF-kappaB transcription factors
2. A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion
3. Mechanisms of cellular injury: Potential sources of oxygen free radicals in ischemia/reperfusion
4. The adult respiratory distress syndrome. Cell populations and soluble mediators in the air spaces of patients at high risk
5. Ischemia-reperfusion lung injury: Contribution of ischemia, neutrophils, and hydrostatic pressure
6. Modulation of neutrophil apoptosis by granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor during the course of acute respiratory dis tress syndrome
7. Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice
8. Macrophages and the immune response
9. Interferon-gamma receptor deficiency: Relationship between genotype, environment, and phenotype (Review)
10. Interferon gamma receptor deficient mice are resistant to endotoxic shock
11. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multi-step paradigm
12. Role of PSGL-1 binding to selectins in leukocyte recruitment
13. The biology of P-selectin glycoprotein ligand-1: Its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction
14. Leukocyte adhesion deficiency: An inherited defect in the Mac- 1, LFA- 1, and P150,95 glycoproteins
15. Neutrophil emigration in the skin, lungs, and peritoneum: Different requirements for CD11/CD18 revealed by CD18-deficient mice
16. Spontaneous skin ulceration and defective T cell function in CD18 null mice
17. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
18. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1
19. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers
20. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
21. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
22. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter
23. Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells
24. Regulation of the tissue factor gene
25. Peptide-directed suppression of a pro-inflammatory cytokine response
26. Innate immunity: Impact on the adaptive immune response
27. A family of human receptors structurally related to Drosophila Toll
28. IRAK: A kinase associated with the interleukin-1 receptor
29. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
30. MyD88 is an adaptor protein in the h Toll/IL-1 receptor family signaling pathways
31. MyD88: An adapter that recruits IRAK to the 1L-1 receptor complex
32. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
33. Unresponsiveness of MyD88-deficient mice to endotoxin
34. MyD genes in negative growth control
35. The NF-kappa B and I kappa B proteins: New discoveries and insights
36. Proteolytic processing of NF-kappa B/I kappa B in human monocytes. ATP-dependent induction by pro-inflammatory mediators
37. Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells
38. IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells
39. Toll-like receptor-2 mediates lipopolys accharide-induced cellular signalling
40. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
41. Nuclear factor of activated T cells transcription factor NFATp controls superantigen-induced lethal shock
42. Transport between the cell nucleus and the cytoplasm
43. Role of NFkappaB in the mortality of sepsis
44. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
45. Cellular import of functional peptides to block intracellular signaling
46. Noninvasive intracellular delivery of functional peptides and proteins
47. Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50
48. Identification of a functionally important sequence in the cytoplasmic tail of integrin beta3 by using cell-permeable peptide analogs
49. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
50. Detection of circulating tumor necrosis factor after endotoxin administration
51. Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects. Influence of elicited hormones and cytokines
52. Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations
53. Experimental endotoxemia in humans: Analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
54. A recombinant human recep tor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice
55. Lipopolysaccharide-induced cytokine cascade and lethality in LT alpha/TNF alpha-deficient mice
56. A D-amino acid peptide inhibitor of NF-kappa B nuclear localization is efficacious in models of inflammatory disease
57. Superantigens: Bacterial and viral proteins that manipulate the immune system
58. Will therapeutic peptides be kryptonite for superantigens?