Identification of IL-1β-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA

Diabetologia

Volumn 42, Issue 10, 1999, Pages 1199-1203

  Chen, M C ^a   Schuit, E ^a   Eizirik, D L ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Adenine nucleotide translocator; Beta cells; Chemokine; CINC 1; CINC 3; DDRT PCR; Interleukin 1; Monocyte chemoattractant protein 1; Phospholipase D

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHOLIPASE D; PROTEIN TYROSINE PHOSPHATASE; ALPHA CHEMOKINE; AUTOANTIGEN; CHEMOTACTIC FACTOR; CXCL1 PROTEIN, HUMAN; CXCL1 PROTEIN, RAT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT, RAT; CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT, RAT; GROWTH PROMOTOR; IA 2 PROTEIN; IA-2 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; MEMBRANE PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; PHOSPHOLIPASE D1; PTPRN2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTER; GENE EXPRESSION REGULATION; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; PANCREAS ISLET;

ANIMALS; AUTOANTIGENS; CHEMOKINE CCL2; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; GENE EXPRESSION; GROWTH SUBSTANCES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1; ISLETS OF LANGERHANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MITOCHONDRIAL ADP, ATP TRANSLOCASES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHOLIPASE D; PROTEIN-TYROSINE-PHOSPHATASE; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032589489     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051292     Document Type: Article

References (28)

1. Bach JF (1995) Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulation. J Autoimmun 8: 439-463
2. Mandrup-Poulsen T (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39: 1005-1029
3. Rabinovitch A, Suarez-Pinzon WL (1998) Cytokines and their roles in pancreatic islet β-cell destruction and insulindependent diabetes mellitus. Biochem Pharmacol 55: 1139-1149
4. Eizirik DL, Flodström M, Karlsen AE, Welsh N (1996) The harmony of the spheres:inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 39: 875-890
5. Mauricio D, Mandrup-Poulsen T (1998) Apoptosis and the pathogenesis of IDDM:a question of life and death. Diabetes 47: 1537-1543
6. Eizirik DL, Hoorens A (1999) B-cell dysfunction and death. In: Howell SL (ed) Biology of the Pancreatic B-Cell. Series Advances in Molecular and Cell Biology 29. JAI Press, Connecticut, USA, pp 47-73
7. Eizirik DL, Pavlovic D (1997) Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes/Metab Rev 13: 293-308
8. Liang P, Pardee AB (1992) Differential display of eukaryotic messenger RNA by means of the polyraerase chain reaction. Science 274: 787-789
9. Bauer D, Müller K, Reich J et al. (1993) Identification of differentially expressed mRNA species by an improved display technique (DDRT-PCR). Nucleic Acids Res 21: 4272-4280
10. Pipeleers DG, In't Veld PA, Van De Winkel M, Maes E, Schuit FC, Gepts W (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117: 806-16
11. Ling Z, Hannaert JC, Pipeleers D (1994) Effect of nutrients, hormones and serum on survival of rat islet β cells in culture. Diabetologia 37: 15-12
12. Chen MC, Sehuit F, Pipeleers DG, Eizirik DL (1999) IL-1β induces serine protease inhibitor 3 (SPI-3) gene expression in rat pancreatic β-cells. Detection by differential display of messenger RNA. Cytokine (in press)
13. Eizirik DL, Björklund A, Cagliero E (1993) Genotoxic agents increase expression of growth arrest and DNA damage-inducible genes gadd 153 and gadd 45 in rat pancreatic islets. Diabetes 42: 738-745
14. Niemann A, Björklund A, Eizirik DL (1994.) Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Mol Cell Endocrinol 106: 151-155
15. Klingenberg M (1992) Structure-function of the ADP/ATP carrier. Biochem Soc Trans 20: 547-550
16. Li K, Warner CK, Hodge JA et al. (1989) A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed. J Biol Chem 264: 13998-14004
17. Welsh N, Svensson C, Welsh M (1989) Content of adenine nucleotide translocator mRNA in insulin-producing cells of different functional states. Diabetes 38: 1377-1380
18. Ling Z, Chen MC, Smismans A et al. (1998) Intercellular differences in interleukin 1β-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic β-cells. Endocrinology 139: 1540-1545
19. Baggiolini M, Dewald B, Moser B (1997) Human chemokines:an update. Annu Rev Immunol 15: 675-705
20. Rollins BJ (1996) Monocyte chemoattractant protein 1:a potential regulator of monocyte recruitment in inflammatory disease. Mol Med Today 2: 198-204
21. Nakagawa H, Komorita N, Shibata F et al. (1994) Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2α and CINC-2β, produced by granulation tissue in culture:purification, complete amino acid sequences and characterization. Biochem J 301: 545-550
22. Grewal IS, Rutledge BJ, Fiorillo JA et al (1997) Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes. J Immunol 159: 401-408
23. Gomez-Cambronero J, Keire P (1998) Phospholipase D:a novel major player in signal transduction. Cell Signal 10: 387-397
24. Eizirik DL, Sandler S, Welsh N, Juntti-Berggren L, Berggren P-O (1995) Interleukin-1β-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglyerol production and protein kinase C activation. Mol Cell Endocrinol 111: 159-165
25. Metz SA and Dunlop M (1990) Stimulation of insulin release by phospholipase D - a potential role for endogenous phosphatidic acid in pancreatic islet function. Biochem J 270: 427-435
26. Passini N, Larigan JD, Genovese S, Appella E, Sinigaglia F (1995) The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc Natl Acad Sci USA 92: 9412-9416
27. Lan MS, Wasserfall C, Maclaren NK, Notkins AL (1996) IA2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 93: 6367-6370
28. Velloso LA, Björk E, Ballagi AE et al. (1994) Regulation of GAD expresion in islets of Langerhans occurs both at the mRNA and protein level. Mol Cell Endocrinol 102: 31-37