NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: Toward a paradigm shift in medication development

Psychopharmacology

Volumn 169, Issue 3-4, 2003, Pages 215-233

  Krystal, John H ^a,b,c   D'Souza, D Cyril ^a,b,c   Mathalon, Daniel ^a,b,c   Perry, Edward ^a,b,c   Belger, Aysenil ^e   Hoffman, Ralph ^b,c,d  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Yale University School of Medicine   (United States)

^d YALE NEW HAVEN HOSPITAL   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebral cortex; Cognitive function; Glutamate; Ketamine; Medications development; N Methyl D aspartate (NMDA); Neural network; Schizophrenia

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; AMPA RECEPTOR AGONIST; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOZAPINE; DEXTRO SERINE; EGLUMETAD; GLUTAMIC ACID; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR AGONIST; GLYCINE RECEPTOR ANTAGONIST; KETAMINE; LAMOTRIGINE; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROLEPTIC AGENT; NIMODIPINE; PHENCYCLIDINE; TOPIRAMATE;

CLINICAL TRIAL; COGNITION; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; HUMAN; MENTAL PATIENT; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROPSYCHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; PSYCHOPHARMACOLOGY; REVIEW; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; CEREBRAL CORTEX; COGNITION; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; KETAMINE; MODELS, NEUROLOGICAL; NEURAL PATHWAYS; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA;

EID: 0142095005     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1582-z     Document Type: Review

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