Medicine: What are the right targets for psychopharmacology?

Science

Volumn 299, Issue 5605, 2003, Pages 350-351

  Hyman, Steven E ^a   Fenton, Wayne S ^b  

^a HARVARD UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; NEUROTRANSMITTER RECEPTOR;

MEDICINE;

AGITATION; ALZHEIMER DISEASE; COGNITION; DISEASE PREDISPOSITION; DNA MICROARRAY; DRUG RESEARCH; DRUG TARGETING; FOOD AND DRUG ADMINISTRATION; GENETIC SUSCEPTIBILITY; HUMAN; MENTAL DISEASE; NEUROTRANSMISSION; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; PSYCHOPHARMACOLOGY; SCHIZOPHRENIA; SHORT SURVEY;

ANIMALS; CLINICAL TRIALS; COGNITION; COGNITION DISORDERS; CONSENSUS DEVELOPMENT CONFERENCES, NIH; HUMANS; MENTAL DISORDERS; NATIONAL INSTITUTE OF MENTAL HEALTH (U.S.); PSYCHOPHARMACOLOGY; PSYCHOTROPIC DRUGS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; UNITED STATES;

EID: 0037449586     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1077141     Document Type: Short Survey

References (24)

1. L. J. van't Veer et al., Nature 415, 484 (2002).
2. Mental Health: A Report of the Surgeon General (Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, National Institute of Mental Health, U.S. Department of Health and Human Services, Rockville, MD, 1999).
3. C. J. L. Murray, A. D. Lopez, Eds. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020 (World Health Organization, Geneva, 1996).
4. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSMV-IV) (American Psychiatric Association, Washington, DC, 1994).
5. The ICD-10 Classification of Mental and Behavioural Disorders (World Health Organization, Geneva, 10th ed., 1992).
6. K. S. Kendler, M. C. Neale, D. Walsh, Am. J. Psychiatry 152, 749 (1995).
7. W. H. Berrettini, Biol. Psychiatry 48, 531 (2002).
8. K. S. Kendler, M. C. Neale, R. C. Kessler, A. C. Heath, L. J. Eaves, Arch. Gen. Psychiatry 49,716 (1992).
9. S. E. Hyman, Psychopathology 35, 2 (2002).
10. W. M. Cowan, K. L. Kopnisky, S. E. Hyman, Annu. Rev. Neurosci. 25, 1 (2002).
11. K. Merikangas, Acta Psychiatr. Scand. 105, 3 (2002).
12. M. F. Green, R. S. Kern, D. L. Braff, J. Mintz, Schizophr. Bull. 26,119 (2000).
13. R. M. Bilder, Am. J. Psychiatry 157, 548 (2000).
14. J. I. Friedman et al., Am. J. Psychiatry 158, 1441 (2001).
15. J. M. Gold, C. Queern, V. N. Iannone, R.W. Buchanan, Am. J. Psychiatry 156, 1937 (1999).
16. C. M. Wilk et al., Am. J. Psychiatry 159, 838 (2002).
17. D. R. Weinberger, K. F. Berman, R. F. Zec, Arch. Gen. Psychiatry 43, 114 (1986).
18. S. S. Kindermann, A. Karimi, L. Symonds, G. G. Brown, D. V. Jeste, Schizophrenia Res. 27, 143 (1997).
19. R. L. Mitchell, R. Elliott, P. W. Woodruff, Trends Cogn. Sci. 5, 71 (2001).
20. S. A. Castner, G. V. Williams, P. S. Goldman-Rakic, Science 287, 2020 (2000).
21. R. Freedman et al., Am. J. Med. Genet. 97, 58 (2000).
22. J. I. Friedman, H. Temporini, K. L. Davis, Biol. Psychiatry 45, 1 (1999).
23. www.nimh.nih.gov/council/2002TreatDevel.cfm
24. The authors acknowledge the assistance of K. Kopnisky in analyzing citation data and the intellectual and programmatic support of E. Stover.