Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: Preliminary findings

Archives of General Psychiatry

Volumn 57, Issue 4, 2000, Pages 349-356

  Rosoklija, Gorazd ^a   Toomayan, Glen ^b   Ellis, Steven P ^c   Keilp, John ^c   Mann, J John ^a   Latov, Norman ^a   Hays, Arthur P ^a   Dwork, Andrew J ^a,c  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2;

ADULT; AFFECTIVE NEUROSIS; AGED; ARTICLE; AUTOPSY; CELL DENSITY; CELL STRUCTURE; CONTROLLED STUDY; DENDRITE; DIAGNOSIS RELATED GROUP; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; GOLGI STAIN; HUMAN; HUMAN TISSUE; INSTITUTIONALIZATION; MALE; MENTAL HOSPITAL; PERIKARYON; PYRAMIDAL NERVE CELL; SCHIZOPHRENIA; SUBICULUM;

EID: 0034115267     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.57.4.349     Document Type: Article

References (49)

1. Goldman-Rakic PS, Selemon LD, Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr Bull. 1997;23:437-458.
2. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry. 1995;52:805-818.
3. Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry. 1995;52:998-1007.
4. Feinberg I. Cortical pruning and the development of schizophrenia. Schizophr Bull. 1990;16:567-570.
5. Keshevan MS, Anderson S, Pettegrew JW. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? the Feinberg hypothesis revisited. J Psychiatr Res. 1994;28:239-265.
6. Harris K, Kater SB. Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Ann Rev Neurosci. 1994;17:341-371.
7. Young CE, Arima K, Xie J, Hu L, Beach TG, Falkai P, Honer WG. SNAP-25 deficit and hippocampal connectivity in schizophrenia. Cereb Cortex. 1998;8:261-268.
8. Arnold SE, Franz BR, Gur RC, Gur RE, Shapiro RM, Moberg PJ, Trojanowski JQ. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry. 1995;152:738-748.
9. Zaidel DW, Esiri MM, Harrison PJ. Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia. Am J Psychiatry. 1997;154:812-818.
10. Arnold SE, Lee VM, Gur RE, Trojanowski JQ. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci U S A. 1991;88:10850-10854.
11. Rosoklija G, Prohovnik I, Keilp JG, Waniek C, Kaufman MA, Haroutunian V, Liu D, Malaspina D, Hays AP, Latov N, Sadiq S, Dwork AJ. Subicular MAP2 immunoreactivity is altered in schizophrenia. J Neurol Neurosurg Psychiatry. In press.
12. Bleuler E. Dementia praecox, oder Gruppe der Schizophrenien. Leipzig, Germany: Deuticke; 1911.
13. Garey LJ, Ong WY, Patel TS, Kanani M, Davis A, Mortimer AM, Barnes TR, Hirsch SR. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J Neurol Neurosurg Psychiatry. 1998;65:446-453.
14. Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry. 2000;57:65-73.
15. Senitz D, Winkelmann E. Neuronal structure abnormality in the orbito-frontal cortex of schizophrenics. J Hirnforsch. 1991;32:149-158.
16. Belichenko PV. Characteristics of the structural reorganization of the neurons of the reticular formation of human brain stem in schizophrenia. Zh Nevrol Psikhiatr Im S S Korsakova. 1989;89:59-61.
17. Roberts RC, Conley R, Kung L, Peretti FJ, Chute DJ. Reduced striatal spine size in schizophrenia: a postmortem ultrastructural study. Neuroreport. 1996;7:1214-1218.
18. Kung L, Conley R, Chute DJ, Smialek J, Roberts RC. Synaptic changes in the striatum of schizophrenic cases: a controlled postmortem ultrastructural study. Synapse. 1998;28:125-139.
19. Keilp JG, Waniek C, Goldman RG, Zemishlany Z, Alexander GE, Gibbon M, Wu A, Susser E, Prohovnik I. Reliability of post-mortem chart diagnoses of schizophrenia and dementia. Schizophr Res. 1995;17:221-228.
20. Dwork AJ, Susser ES, Keilp J, Waniek C, Liu D, Kaufman M, Zemishlany Z, Prohovnik I. Senile degeneration and cognitive impairment in chronic schizophrenia. Am J Psychiatry. 1988;155:1536-1543.
21. Lund JS. Organization of neurons in the visual cortex, area 17, of the monkey (macaca mulatta). J Comp Neurol. 1973;147:455-496.
22. Nebelthau E. Gehirndurchschnitte zur Erläuterung des Faserverlaufes. Wiesbaden, Germany: Verlag von JF Bergmann: 1898:20-21.
23. Sholl DA. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat. 1953;87:387-406.
24. Efron B, Tibshirani RG. An Introduction to the Bootstrap. New York, NY: Chapman & Hall; 1993:202-220.
25. Bickel PJ, Doksum KA. Mathematical Statistics: Basic Ideas and Selected Topics. San Francisco, Calif: Holden-Day: 1977:209, 229.
26. Searle SR, Casella G, McCulloch CE. Variance Components. New York, NY: John Wiley & Sons Inc; 1992.
27. Finch DM, Nowlin NL, Babb TL. Demonstration of axonal projections of neurons in the rat hippocampus and subiculum by intracellular injection of HRP. Brain Res. 1983;271:201-216.
28. Kosel KC, VanHoesen GW, Rosene DL. A direct projection from the perirhinal cortex (area 35) to the subiculum in the rat. Brain Res. 1983;269:347-351.
29. Verney C, Baulac M, Berger B, Alvarez C, Vigny A, Helle KB. Morphological evidence for a dopaminergic terminal field in the hippocampal formation of young and adult rat. Neuroscience. 1985;14:1039-1052.
30. Aggleton JP. A description of the amygdala-hippocampal interconnections in the macaque monkey. Exp Brain Res. 1986;64:515-526.
31. Behr J, Gloveli T, Heinemann U. The perforant path projection from the medial entorhinal cortex layer III to the subiculum in the rat combined hippocampal-entorhinal cortex slice. Eur J Neurosci. 1998;10:1011-1018.
32. Roy MA, Walsh D, Kendler KS. Accuracies and inaccuracies of the family history method: a multivariate approach. Acta Psychiatr Scand. 1996;93:224-234.
33. Velakoulis D, Pantelis C, McGorry PD, Dudgeson P, Cook M, Desmond P, Bridle N, Tierney P, Murrie V, Singh B, Copolov D. Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Arch Gen Psychiatry. 1999;56:133-140.
34. Hirayasu Y, Shenton ME, Salisbury DF, Dickey CC, Fischer IA, Mazzoni P, Kisler T, Arakaki H, Kwon JS, Anderson JE, Yurgelun-Todd D, Tohen M, McCarley RW. Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry. 1998;155:1384-1391.
35. Benes FM, Kwok EW, Vincent SL, Todtenkopf MS. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry. 1998;44:88-97.
36. Kendler KS, Karkowski LM, Walsh D. The structure of psychosis: latent class analysis of probands from the Roscommon Family Study. Arch Gen Psychiatry. 1998; 55:492-499.
37. Hirayasu Y, Shenton ME, Salisbury DF, Wible CG, Fischer IA, Kisler T, Kwon JS, Dickey CC, Yurgelun-Todd DA, Tohen M, McCarley RW. Subgenual prefrontal cortex reduction in first episode affective psychosis [abstract]. Biol Psychiatry. 1998;43(suppl):97S.
38. Öngür D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A. 1998;95:13290-13295.
39. Decina P, Mukherjee S, Lucas L, Linder J, Horwath E. Patterns of illness in parent-child pairs both hospitalized for either schizophrenia or a major mood disorder. Psychiatry Res. 1991;39:81-87.
40. Gutierrez B, Van Os J, Valles V, Guillamat R, Campillo M, Fananas L. Congenital dermatoglyphic malformations in severe bipolar disorder. Psychiatry Res. 1998; 78:133-140.
41. Erlenmeyer-Kimling L, Adamo UH, Rock D, Roberts SA, Bassett AS, Squires-Wheeler E, Cornblatt BA, Endicott J, Pape S, Gottesman II. The New York High-Risk Project: prevalence and comorbidity of axis I disorders in offspring of schizophrenic parents at 25-year follow-up. Arch Gen Psychiatry. 1997;54:1096-1102.
42. Kendler KS, Karkowski-Shuman L, Walsh D. The risk for psychiatric illness in siblings of schizophrenics: the impact of psychotic and non-psychotic affective illness and alcoholism in parents. Acta Psychiatr Scand. 1996;94:49-55.
43. Uranova NA, Orlovskaya DD, Apel K, Klintsova AJ, Haselhorst U, Schenk H. Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment. Synapse. 1991;7:253-259.
44. Kerns JM, Sierens DK, Kao LC, Klawans HL, Carvey PM. Synaptic plasticity in the rat striatum following chronic haloperidol treatment. Clin Neuropharmacol. 1992;15:488-500.
45. Kelley JJ, Gao XM, Tamminga CA, Roberts RC. The effect of chronic haloperidol treatment on dendritic spines in the rat striatum. Exp Neurol. 1997;146:471-478.
46. Benes FM, Paskevich PA, Davidson J, Domesick VB. Synaptic rearrangements in medial prefrontal cortex of haloperidol-treated rats. Brain Res. 1985;348:15-20
47. Vincent SL, McSparren J, Wang RY, Benes FM. Evidence for ultrastructural changes in cortical axodendritic synapses following long-term treatment with haloperidol or clozapine. Neuropsychopharmacology. 1991;5:147-155.
48. Buell SJ. Golgi-Cox and rapid Golgi methods as applied to autopsied human brain tissue: widely disparate results. J Neuropathol Exp Neurol. 1982;41:500-507.
49. Williams RS, Ferrante RJ, Caviness VS Jr. The Golgi rapid method in clinical neuropathology: the morphologic consequences of suboptimal fixation. J Neuropathol Exp Neurol. 1978;37:13-33.