Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase

Journal of Medicinal Chemistry

Volumn 39, Issue 2, 1996, Pages 619-622

  Jackson, Paul F ^a,b   Cole, Derek C ^a   Slusher, Barbara S ^a,b   Stetz, Susan L ^a   Ross, Laurie E ^a   Donzanti, Bruce A ^a   Trainor, Diane Amy ^a  

^a ASTRAZENECA   (United Kingdom)

^b GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (PHOSPHONOMETHYL)PENTANEDIOIC ACID; DIPEPTIDASE; ENZYME INHIBITOR; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; NEUROPEPTIDASE; NEUROPEPTIDE; NEUROTRANSMITTER; PHOSPHONIC ACID DERIVATIVE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INHIBITION KINETICS; INTRACEREBRAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; RAT;

ACETYLATION; ANIMALS; CENTRAL NERVOUS SYSTEM; DIPEPTIDASES; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; GLUTAMATE CARBOXYPEPTIDASE II; HYDROGEN-ION CONCENTRATION; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030053446     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950801q     Document Type: Article

References (22)

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