Phencyclidine increases forebrain monoamine metabolism in rats and monkeys: Modulation by the isomers of HA966

Journal of Neuroscience

Volumn 17, Issue 5, 1997, Pages 1769-1775

  Jentsch, J David ^a   Elsworth, John D ^a   Redmond Jr , D Eugene ^a   Roth, Robert H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

dopamine; HA966; monkey; phencyclidine; prefrontal cortex; psychotomimetic; rat; schizophrenia; serotonin; turnover

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; DOPAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; SEROTONIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG EFFECT; FRONTAL CORTEX; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MENTAL DISEASE; MONKEY; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM;

EID: 0031046781     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-05-01769.1997     Document Type: Article

References (50)

1. Bean AJ, Roth RH (1991) Extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, pattern and dopamine autoreceptors. J Neurosci 11:2694-2702.
2. Bowers MB, Hoffman FJ (1989) Effects of diazepam on regional brain homovanillic acid following phencyclidine or Δ9-tetrahydrocannabinol. Biochem Pharmacol 38:2385-2387.
3. Bowers MB, Morton JB (1992) Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists. Prog Neuropsychopharmacol Biol Psychiatry 16:211-215.
4. Bowers MB, Morton JB (1994) Regional brain catecholamines and metabolites following THC, PCP and MK-801. Prog Neuropsychopharmacol Biol Psychiatry 18:961-964.
5. Bristow LJ, Hutson PH, Thorn L, Tricklebank MD (1993) The glycine/ NMDA receptor antagonist, R-(+)HA966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents. Br J Pharmacol 108:1156-1163.
6. Chergui K, Charlety PJ, Akaoka H, Saunier CF, Brunet JL, Buda M, Svensson TH, Chouvet G (1993) Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur J Neurosci 5:137-144.
7. Deutch AY (1992) The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J Neural Transm Suppl 36:61-89.
8. Deutch AY, Roth RH (1990) The determinants of stress-induced activation of the prefrontal cortical dopamine system. In: The prefrontal cortex: its structure, function and pathology (Vylings HBM, Van Eden CG, DeBruim JPC, Corner MA, Feenstra MGP, eds), pp 367-403. Amsterdam: Elsevier.
9. Deutch AY, Tam SY, Freeman AS, Bowers MB, Roth RH (1987) Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Eur J Pharmacol 134:257-264.
10. During MJ, Bean AJ, Roth RH (1987) Effects of CNS stimulants on the in vivo release of the colocalized transmitters, dopamine and neurotensin, from rat prefrontal cortex. Neurosci Lett 140:129-133.
11. Fadda F, Argiolas A, Melis MR, Tissari AH, Onali PL, Gessa GL (1978) Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in N. accumbens: reversal by diazepam. Life Sci 23:2219-2224.
12. Freedman AS, Bunney BS (1984) The effects of phencyclidine and N-allyl-normetazocine on midbrain dopamine neuronal activity. Eur J Pharmacol 104:287-293.
13. French ED (1992) Competitive NMDA receptor antagonists attenuate phencyclidine-induced excitations of A10 dopamine neurons. Eur J Pharmacol 271:1-7.
14. French ED (1994) Phencyclidine and the midbrain dopamine system: electrophysiology and behavior. Neurotoxicol Teratol 16:355-362.
15. Goldstein LE, Rasmusson AM, Bunney BS, Roth RH (1994) The NMDA glycine site antagonist (+)HA966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat. J Neurosci 14:4937-4950.
16. Gonon FG (1988) Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience 24:19-28.
17. Grace AA (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41:1-24.
18. Grace AA, Bunney BS (1984a) The control of firing pattern in nigral dopamine neurons: single spike firing. J Neurosci 4:2866-2876.
19. Grace AA, Bunney BS (1984b) The control of firing pattern in nigral dopamine neurons: burst firing. J Neurosci 4:2877-2890.
20. Grenhoff J, Tung CS, Svensson TH (1988) The excitatory amino acid antagonist kynurenate induces pacemaker-like firing of dopamine neurons in the rat ventral tegmental area. Acta Physiol Scand 134:567-568.
21. Grobaski KC, Ping H, daSilva HMA, Bowery NG, Connelly ST, Shepard PD (1997) Responses of rat substantia nigra dopamine-containing neurons to S-(-)HA966 in vitro. Br J Pharmacol, in press.
22. Hondo H, Yonezawa Y, Nakahara T, Nakamura K, Hirano M, Uchimura H, Tashiro N (1994) Effect of phencyclidine on dopamine release in the rat prefrontal cortex: an in vivo microdialysis study. Brain Res 633:337-342.
23. Horger BA, Roth RH (1995) Stress and central amino acid systems. In: Neurobiological and clinical consequences of stress: from normal adaptation to PTSD (Friedman MJ, Charney DS, Deutch AY, eds), pp 61-81. Philadelphia: Lippincott-Raven.
24. Horger BA, Elsworth JD, Roth RH (1996) Blockade of FG7142-induced increased dopamine utilization by the glycine/NMDA receptor antagonist (+)HA966. J Neurochem 66:1959-1962.
25. Ital T, Keskiner A, Kiremitci N, Holden JMC (1967) Effect of phencyclidine in chronic schizophrenics. Can Psychiatric Assoc J 12:209-212.
26. Javitt DC, Zukin SR (1991) Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301-1308.
27. Jentsch JD, Andrusiak EA, Tran A, Bowers MB, Roth RH (1997) Δ9-tetrahydrocannabinol increases prefrontal cortical catecholaminergic turnover and impairs spatial working memory in the rat: selective blockade of dopaminergic effects with HA966. Neuropsychopharmacology, in press.
28. Kim HS, lyengar S, Wood PL (1986) Opiate actions on mesocortical dopamine metabolism in the rat. Life Sci 39:2033-2036.
29. Krystal JH, Karper JP, Seibyl JP, Freeman AS, Delaney GK, Bremner JD, Heninger GR, Bowers MB, Charney DS (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive and neuroendocrine responses. Arch Gen Psychiatry 51:199-214.
30. Lavielle S, Tassin JP, Thierry AM. Blanc G. Herve D, Bathelemy C, Glowinski J (1978) Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat. Brain Res 168:585-594.
31. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
32. Luby ED, Cohen BD, Rosenbaum G, Gottlieb JS, Kelley R (1959) Study of a new schizophrenomimetic drug - sernyl. Arch Neurol Psychiatry 81:363-369.
33. Luby ED, Gottlieh JS, Cohen BD, Rosenbaum G, Domino EF (1962) Model psychoses and schizophrenia. Am J Psychiatry 119:61-67.
34. McMillen BA, Williams HL, Lehmann H, Shepard PD (1992) On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA966. J Neural Transm Gen Sec 89:11-25.
35. Mocsary Z, Roth RH (1994) Effects of HA966 and its enantiomers on dopamine neurotransmission in the striatum and the nucleus accumbens. Soc Neurosci Abstr 20:284.
36. Morrow BA, Clark WA, Roth RH (1993) Stress activation of mesocorticolimbic dopamine neurons: effects of a glycine/NMDA receptor antagonist. Eur J Pharmacol 238:255-262.
37. Morrow BA, Lee EJK, Elsworth JD, Nye H, Roth RH (1995) S-(-)HA966, a γ-hydroxybutyrate-like agonist, blocks behavioral and mesoaccumbal, in addition to, mesocortical dopaminergic stress activation. Soc Neurosci Abstr 21:852.
38. Murphy BL, Arnsten AFT, Goldman-Rakic PS, Roth RH (1996a) Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Natl Acad Sci USA 93:1325-1329.
39. Murphy BL, Arnsten AFT, Jentsch JD, Roth RH (1996b) (+)HA966 and clonidine block FG7142-induced increases in prefrontal cortical dopamine turnover and prevent stress-induced impairments in spatial working memory in rats and monkeys. Soc Neurosci Abstr 22:161.
40. Murphy BL, Arnsten AFT, Jentsch JD, Roth RH (1996c) Dopamine and spatial working memory: pharmacological modulation of FG7142-induced impairment. J Neurosci 16:7768-7775.
41. Raja SN, Guyenet PG (1980) Effects of phencyclidine on the spontaneous activity of monoaminergic neurons. Eur J Pharmacol 63:229-233.
42. Reinhard JF, Bannon MJ, Roth RH (1982) Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: antagonism by diazepam. Naunyn Schmiedebergs Arch Pharmacol 318:374-377.
43. Robbins TW (1990) The case for frontostriatal dysfunction in schizophrenia. Schizophr Bull 16:391-402.
44. Roth RH, Elsworth JD (1995) Biochemical pharmacology of midbrain dopamine neurons. In: Psychopharmacology, the fourth generation of progress (Bloom FE, Kupfer DJ, eds), pp 227-243. New York: Raven.
45. Shepard PD, Connelly ST, Lehmann H, Grobaski KC (1996) Effects of the enantiomers of (±)HA966 on dopamine neurons: an electrophysiological study of a chiral molecule. Eur J Pharmacol 285:79-88.
46. Singh L, Donald AE, Foster AC, Hutson PH, Iversen LL, Iversen SD, Kemp JA, Leeson PD, Marshall GR, Oles RJ, Priestley T, Thorn L, Tricklebank MD, Vass CA, Williams BA (1990) Enantiomers of HA966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-buryrolactone-like sedative. Proc Natl Acad Sci USA 87:347-351.
47. Sorg BA, Kalivas PW (1993) Effect of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. Neuroscience 53:695-703.
48. Thierry AM, Tassin JP, Blanc G, Glowinski J (1976) Selective activation of the mesocortical DA system by stress. Nature 263:242-244.
49. Verma A, Moghaddam B (1996) NMDA receptor antagonists impair prefrontal cortical function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci 16:373-379.
50. Wu HQ, Schwarcz R, Shepard PD (1994) Excitatory amino acid-induced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid. Synapse 16:219-230.