Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain

Synapse

Volumn 29, Issue 4, 1998, Pages 323-332

  Todtenkopf, Mark S ^a   Benes, Francine M ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Glutamate decarboxylase; Hippocampus; Nonpyramidal neurons; Pyramidal neurons; Schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GLUTAMATE DECARBOXYLASE; ISOENZYME;

ARTICLE; COGNITION; ENZYME ACTIVITY; ENZYME LOCALIZATION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NARCOLEPSY; NERVE DEGENERATION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SCHIZOPHRENIA; STATISTICAL ANALYSIS; ADULT; AGED; ENZYMOLOGY; METABOLISM; MIDDLE AGED; NERVE CELL; PATHOLOGY; TISSUE DISTRIBUTION;

ADULT; AGED; AGED, 80 AND OVER; GLUTAMATE DECARBOXYLASE; HIPPOCAMPUS; HUMANS; ISOENZYMES; MIDDLE AGED; NEURONS; PYRAMIDAL CELLS; SCHIZOPHRENIA; TISSUE DISTRIBUTION;

EID: 0031595945     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199808)29:4<323::AID-SYN4>3.0.CO;2-7     Document Type: Article

References (37)

1. Akbarian, S., Bunney, W.E., Potkin, S.G., Wigal, S.B., Hagman, J.D., Sandman, C.A., and Jones, E.G. (1993) Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch. Gen. Psychiatry, 50:227-230.
2. A Receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls. Cerebral Cortex, 5(6):550-560.
3. Akbarian, S., Kim, J.J., Potkin, S.G., Hagman, J.O., Tafazzoli, A., Bunney, W.E., and Jones, E.G. (1995b) Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch. Gen. Psychiatry, 52:258-266.
4. Arnold, S.E., Franz, B.R., Gur, R.C., Gur, R.E., Shapiro, R.M., Moberg, P.J., and Trojanowski, J.Q. (1995) Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am. J. Psychiatry, 152:738-748.
5. Benes, F.M. (1988) Post-mortem structural analyses of schizophrenic brain. Study designs and the interpretation of data. Psychiatr. Dev., 6:213-226.
6. Benes, F.M. (1993a) Neurobiological investigations in cingulate cortex of schizophrenic brain. Schiz. Bull., 19:537-549.
7. Benes, F.M. (1993b) The relationship between structural brain imaging and histopathologic findings in schizophrenia research. Harvard Rev. Psychiatry, 1:100-109.
8. Benes, F.M. (1995) Is there a neuroanatomic basis for schizophrenia? Neuroscientist, 1:112-120.
9. Benes, F.M., Davidson, J., and Bird, E.D. (1986) Quantitative cytoarchitectural studies of cerebral cortex of schizophrenics. Arch. Gen. Psychiatry, 43:31-35.
10. Benes, F.M., Vincent, S.L., and SanGiovanni, J.P. (1989) High resolution imaging of receptor binding in analyzing neuropsychiatric diseases. Biotechniques, 7:970-979.
11. Benes, P.M., McSparren, J., Bird, E.D., Vincent, S.L., and SanGiovanni, J.P. (1991) Deficits in small interneurons in prefrontal and anterior cingulate cortex of schizophrenic and schizoaffective patients. Arch. Gen. Psychiatry, 48:996-1001.
12. Benes, F.M., Sorensen, I., Vincent, S.L., Bird, E.D., and Sathi, M. (1992a) Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain. Cerebral Cortex, 2:502-512.
13. A receptor binding in superficial layers of cingulate cortex in schizophrenics. J. Neurosci., 12:924-929.
14. A receptor binding in the hippocampal formation of schizophrenic brain. Synapse, 22:338-349.
15. A receptor binding on pyramidal neurons of prefrontal cortex in schizophrenic subjects. Neuroscience, 75:1021-1031.
16. A and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain. Brain 755:121-129.
17. Bird, E.D., Spokes, E.G.S., and Iversen, L.L. (1979) Increased dopamine concentration in limbic areas of brain from patients dying with schizophrenia. Brain, 102:347-360.
18. Bogerts, B., Falkai, P., and Tutsch, J. (1986) Cell numbers in the pallidum and hippocampus of schizophrenics. In: Biol. Psychiatry, Vol. 27. C. Shagass et al., eds. Elsevier Press, Amsterdam, pp. 1178-1180.
19. Falkai, P., and Bogerts, B. (1986) Cell loss in the hippocampus of schizophrenics. Eur. Arch. Psychiat. Neurol. Sci., 236:54-161.
20. Feighner, J.P., Robins, E., and Guze, S.B. (1972) Diagnostic criteria for use in psychiatric research. Arch. Gen. Psychiatry, 26:57-63.
21. 3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics. Life Sci., 40:259-266.
22. Heckers, S., Heinsen, H., Geiger, B., and Beckmann, H. (1991) Hippocampal neuron number in schizophrenia. Arch. Gen. Psychiatry, 48:1002-1008.
23. Jakob, H., and Beckmann, H. (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J. Neural Transm., 65:303-326.
24. Jeste, D., and Lohr, J.B. (1989) Hippocampal pathologic findings in schizophrenia. Arch. Gen. Psychiatry, 46:1019-1024.
25. Kaufman, D.L., Houser, C.R., and Tobin, A.J. (1991) Two forms of the γ-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem., 56:720-723.
26. Kerwin, R., Patel, S., and Meldrum, B. (1990) Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience, 39:25-32.
27. Kovelman, J.A., and Scheibel, A.B. (1984) A neurohistological correlate of schizophrenia. Biol. Psychiatry, 19:601-1621.
28. Kraeplin, E. (1919) Dementia Praecox and Paraphrenia. E. Livingston, E. and S.) Edinburg.
29. A/Benzodiazepine receptor α1, β2, and γ2 subunit mRNA expression in cerebellar purkinje cells of staggerer mutant mouse. J. Neurosci., 15:8121-8130.
30. Olsen, R.W., Stauber, G.B., King, R.G., Yang, J., and Dilber, A. (1985) Structure and function of the barbiturate-modulated benzodiazepine/GABA receptor protein complex. Lett. Nature, 314:21-22.
31. Reynolds, G.P., Czudek, C., and Andrews, H.B. (1990) Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia. Biol. Psychiatry, 27:1038-1044.
32. Shenton, M.E., Kikinis, R., Jolesz, F.A., Pollak, S.D., LeMay, M., Wible, C.G., Hokama, H., Martin, J., Metcalf, D., Coleman, M., and McCarley, R.W. (1992) Abnormalities of the left temporal lobe and thought disorder in schizophrenia. N. Engl. J. Med., 327:604-612.
33. Simpson, M.D.C., Slater, P., Deakin, J.F.W., Royston, M.C., and Skan, W.J. (1989) Reduced GABA uptake sites in the temporal lobe in schizophrenia. Neurosci. Lett., 107:211-215.
34. Suddath, R.L., Christison, G.W., Torrey, E.F., Casanova, M.F., and Weinberger, D.R. (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 322:789-794.
35. Swann, J.W., Brady, R.J., and Martin, D.L. (1989) Postnatal development of GABA-mediated synaptic inhibition in rate hippocampus. Neuroscience, 28:551-561.
36. Weinberger, D.R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry, 44:660-669.
37. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci., 12: 1040-1062.