Mechanism and impact of allosteric AMPA receptor modulation by the Ampakine™ CX546

Neuropharmacology

Volumn 41, Issue 6, 2001, Pages 650-663

  Nagarajan, Naveen ^a   Quast, Christoph ^a   Boxall, Andrew R ^b   Shahid, Mohammed ^b   Rosenmund, Christian ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric mechanism; Benzothiadiazides; Benzoylpiperidines; Desensitization; Hippocampus; Synaptic transmission

Indexed keywords

6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; 7 CHLORO 3,4 DIHYDRO 3 METHYL 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; AMPA RECEPTOR; AMPAKINE; CX 546; CYCLOTHIAZIDE; GLUTAMATE RECEPTOR; PIPERIDINE DERIVATIVE; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; SYNAPTIC POTENTIAL;

ALLOSTERIC REGULATION; BENZOTHIADIAZINES; CELL LINE; DIOXOLES; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HUMANS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; RECEPTORS, AMPA; SYNAPTIC TRANSMISSION;

EID: 0034793047     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00133-2     Document Type: Article

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