메뉴 건너뛰기




Volumn 4, Issue 5, 2003, Pages 597-621

The application of functional genomics to Alzheimer's disease

Author keywords

Alzheimer's disease; APOE; CYP2D6; Functional genomics; Genetic variation; Genetics; Genomics; Genotype phenotype correlations; Pharmacogenetics; Pharmacogenomics

Indexed keywords

AMITRIPTYLINE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CHLORPROMAZINE; CITICOLINE; CLOMIPRAMINE; CLOZAPINE; CYTOCHROME P450 2D6; DESIPRAMINE; DONEPEZIL; FLUOXETINE; FLUPHENAZINE; HALOPERIDOL; IMIPRAMINE; MAPROTILINE; MIANSERIN; MINAPRINE; NEFAZODONE; NORTRIPTYLINE; PAROXETINE; PERPHENAZINE; PIRACETAM; POLYPODIUM LEUCOTOMOS EXTRACT; REBOXETINE; RISPERIDONE; TACRINE; THIORIDAZINE; TRAZODONE; UNINDEXED DRUG; VENLAFAXINE;

EID: 0141851356     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/phgs.4.5.597.23795     Document Type: Review
Times cited : (69)

References (117)
  • 2
    • 0011589226 scopus 로고    scopus 로고
    • Psychogeriatric research. A conceptual introduction to geriatric neuroscience
    • Cacabelos R: Psychogeriatric research. A conceptual introduction to geriatric neuroscience. Psychogeriatrics 1, 158-188 (2001).
    • (2001) Psychogeriatrics , vol.1 , pp. 158-188
    • Cacabelos, R.1
  • 5
    • 0036484691 scopus 로고    scopus 로고
    • Pharmacogenomics in Alzheimer's disease
    • Cacabelos R: Pharmacogenomics in Alzheimer's disease. Min. Rev. Med. Chem. 2, 59-84 (2002).
    • (2002) Min. Rev. Med. Chem. , vol.2 , pp. 59-84
    • Cacabelos, R.1
  • 6
    • 0036434139 scopus 로고    scopus 로고
    • Pharmacogenomics for the treatment of dementia
    • Cacabelos R: Pharmacogenomics for the treatment of dementia. Ann. Med. 34, 357-379 (2002).
    • (2002) Ann. Med. , vol.34 , pp. 357-379
    • Cacabelos, R.1
  • 7
    • 0037411512 scopus 로고    scopus 로고
    • Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease
    • Frank RA, Galsko D, Hampel H et al.: Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease. Neurobiol. Aging 24, 521-536 (2003).
    • (2003) Neurobiol. Aging , vol.24 , pp. 521-536
    • Frank, R.A.1    Galsko, D.2    Hampel, H.3
  • 8
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81,741-766 (2001).
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 9
    • 0003147139 scopus 로고    scopus 로고
    • Dementia
    • Jobe TH, Gaviria M, Kovilparambil A (Eds.), Blackwell Science, Massachusetts, USA
    • Cacabelos R: Dementia. In: Clinical Psychiatry. Jobe TH, Gaviria M, Kovilparambil A (Eds.), Blackwell Science, Massachusetts, USA, 73-122 (1997).
    • (1997) Clinical Psychiatry , pp. 73-122
    • Cacabelos, R.1
  • 10
    • 0029691640 scopus 로고    scopus 로고
    • Diagnosis of Alzheimer's disease: Defining genetic profiles (genotype versus phenotype)
    • Cacabelos R: Diagnosis of Alzheimer's disease: defining genetic profiles (genotype versus phenotype). Acta Neurol. Scand. 165, 72-84 (1996).
    • (1996) Acta Neurol. Scand. , vol.165 , pp. 72-84
    • Cacabelos, R.1
  • 11
    • 0033668944 scopus 로고    scopus 로고
    • Evidence that Alzheimer's disease is a microvascular disorder: The role of constitutive nitric oxide
    • De la Torre JC, Stefano GB: Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res. Rev 34, 119-136 (2000).
    • (2000) Brain Res. Rev , vol.34 , pp. 119-136
    • De la Torre, J.C.1    Stefano, G.B.2
  • 13
    • 0033850870 scopus 로고    scopus 로고
    • Pharmacological treatment of Alzheimer's disease: From phychotropic drugs and cholinesterase inhibitors to pharmacogenomics
    • Cacabelos R, Alvarez XA, Lombardi V et al.: Pharmacological treatment of Alzheimer's disease: from phychotropic drugs and cholinesterase inhibitors to pharmacogenomics. Drugs Today 36, 415-499 (2000).
    • (2000) Drugs Today , vol.36 , pp. 415-499
    • Cacabelos, R.1    Alvarez, X.A.2    Lombardi, V.3
  • 15
    • 0003873301 scopus 로고    scopus 로고
    • Wiley, New York, USA The Science and Technology behind the Human Genome Project
    • Cantor CR, Smith CL: Genomics. The Science and Technology behind the Human Genome Project. Wiley, New York, USA (1999).
    • (1999) Genomics
    • Cantor, C.R.1    Smith, C.L.2
  • 16
    • 0004155865 scopus 로고    scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA Sequence and Genome Analysis
    • Mount DW: Bioinformatics. Sequence and Genome Analysis. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA (2001).
    • (2001) Bioinformatics
    • Mount, D.W.1
  • 17
    • 0004210366 scopus 로고    scopus 로고
    • Bishop T, Sham P (Eds), BIOS Scientific Publishers, Oxford, UK
    • Analysis of Multifactorial Disease. Bishop T, Sham P (Eds), BIOS Scientific Publishers, Oxford, UK (2000).
    • (2000) Analysis of Multifactorial Disease
  • 19
    • 0032491408 scopus 로고    scopus 로고
    • Genetic classification of primary degenerative disease
    • Hardy J, Gwinn-Hardy K: Genetic classification of primary degenerative disease. Science 282, 1075-1079 (1998).
    • (1998) Science , vol.282 , pp. 1075-1079
    • Hardy, J.1    Gwinn-Hardy, K.2
  • 20
    • 0030174981 scopus 로고    scopus 로고
    • The gene defects responsible for familial Alzheimer's disease
    • Tanzi RE, Kovacs DM, Kim TW et al.: The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3, 159-168 (1996).
    • (1996) Neurobiol. Dis. , vol.3 , pp. 159-168
    • Tanzi, R.E.1    Kovacs, D.M.2    Kim, T.W.3
  • 22
    • 0034509668 scopus 로고    scopus 로고
    • Genetic factors in the genesis of Alzheimer's disease
    • St. George-Hyslop PH: Genetic factors in the genesis of Alzheimer's disease. Ann. NY Acad. Sci. 924, 1-7 (2000).
    • (2000) Ann. NY Acad. Sci. , vol.924 , pp. 1-7
    • St. George-Hyslop, P.H.1
  • 23
    • 0031921466 scopus 로고    scopus 로고
    • Mutant genes in familial Alzheimer's disease and transgenic models
    • Price DL, Sisodia SS: Mutant genes in familial Alzheimer's disease and transgenic models. Ann. Rev. Neurosci. 21, 479-505 (1998).
    • (1998) Ann. Rev. Neurosci. , vol.21 , pp. 479-505
    • Price, D.L.1    Sisodia, S.S.2
  • 24
    • 0037378001 scopus 로고    scopus 로고
    • Amyloid, presenilins, and Alzheimer's disease
    • Van Gassen G, Annaert W: Amyloid, presenilins, and Alzheimer's disease. Neuroscientist 9, 117-126 (2003).
    • (2003) Neuroscientist , vol.9 , pp. 117-126
    • Van Gassen, G.1    Annaert, W.2
  • 25
  • 26
    • 0034307463 scopus 로고    scopus 로고
    • The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress
    • Greeve I, Hermans-Borgmeyer I, Brellinger C et al.: The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J. Neurosci. 20, 7345-7352 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 7345-7352
    • Greeve, I.1    Hermans-Borgmeyer, I.2    Brellinger, C.3
  • 27
    • 0034971263 scopus 로고    scopus 로고
    • Lack of replication of association findings in complex disease: An analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease
    • Prince JA, Feuk L, Swayer SL et al.: Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur. J. Genet. 9, 437-444 (2001).
    • (2001) Eur. J. Genet. , vol.9 , pp. 437-444
    • Prince, J.A.1    Feuk, L.2    Swayer, S.L.3
  • 28
    • 0033654196 scopus 로고    scopus 로고
    • Candidate genes showing no evidence for association or linkage with Alzheimer's disease
    • Bertram L, Blacker D, Crystal A et al.: Candidate genes showing no evidence for association or linkage with Alzheimer's disease. Exp. Gerontol. 35, 1353-1361 (2000).
    • (2000) Exp. Gerontol. , vol.35 , pp. 1353-1361
    • Bertram, L.1    Blacker, D.2    Crystal, A.3
  • 29
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN: Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genetics 33, 177-182 (2003).
    • (2003) Nat. Genetics , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 31
    • 0037426052 scopus 로고    scopus 로고
    • Problems reporting genetic associations with complex outcomes
    • Colhoun HM, McKeigue PM, Smith GD: Problems reporting genetic associations with complex outcomes. Lancet 361, 865-872 (2003).
    • (2003) Lancet , vol.361 , pp. 865-872
    • Colhoun, H.M.1    McKeigue, P.M.2    Smith, G.D.3
  • 33
    • 0033866289 scopus 로고    scopus 로고
    • Pharmacogenomics in Alzheimer's disease
    • Cacabelos R: Pharmacogenomics in Alzheimer's disease. Drug News Perspect. 13, 252-254 (2000).
    • (2000) Drug News Perspect. , vol.13 , pp. 252-254
    • Cacabelos, R.1
  • 35
    • 0035254224 scopus 로고    scopus 로고
    • Exploiting human genetic variation in drug discovery and development
    • Jazwinska EC: Exploiting human genetic variation in drug discovery and development. Drug Dis. Today 6, 198-205 (2001).
    • (2001) Drug Dis. Today , vol.6 , pp. 198-205
    • Jazwinska, E.C.1
  • 37
    • 0036075767 scopus 로고    scopus 로고
    • Race, ethnicity, and genomics: Social classifications as proxies of biological heterogeneity
    • Foster MW, Sharp RR: Race, ethnicity, and genomics: social classifications as proxies of biological heterogeneity. Genome Res. 12, 844-850 (2002).
    • (2002) Genome Res. , vol.12 , pp. 844-850
    • Foster, M.W.1    Sharp, R.R.2
  • 38
    • 0035941029 scopus 로고    scopus 로고
    • Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
    • Patil N, Berno AJ, Hinds DA et al.: Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294, 1719-1723 (2001).
    • (2001) Science , vol.294 , pp. 1719-1723
    • Patil, N.1    Berno, A.J.2    Hinds, D.A.3
  • 39
    • 0036789519 scopus 로고    scopus 로고
    • Variation in gene expression within and among natural populations
    • Oleksiak MF, Curchill GA, Crawford DL: Variation in gene expression within and among natural populations. Nat. Genetics 32, 261-266 (2002).
    • (2002) Nat. Genetics , vol.32 , pp. 261-266
    • Oleksiak, M.F.1    Curchill, G.A.2    Crawford, D.L.3
  • 40
    • 0036078078 scopus 로고    scopus 로고
    • Essential genes are more evolutionarily conserved than are nonessential genes in bacteria
    • Jordan IK, Rogozin IB, Wolf YI, Koonin EV: Essential genes are more evolutionarily conserved than are nonessential genes in bacteria. Genome Res. 12, 962-968 (2002).
    • (2002) Genome Res. , vol.12 , pp. 962-968
    • Jordan, I.K.1    Rogozin, I.B.2    Wolf, Y.I.3    Koonin, E.V.4
  • 41
    • 0037012844 scopus 로고    scopus 로고
    • Axonal self-destruction and neurodegeneration
    • Raff MC, Whitmore AV, Finn JT. Axonal self-destruction and neurodegeneration. Science 296, 868-871 (2002).
    • (2002) Science , vol.296 , pp. 868-871
    • Raff, M.C.1    Whitmore, A.V.2    Finn, J.T.3
  • 43
    • 0037381011 scopus 로고    scopus 로고
    • In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading
    • Knight JC, Keating BJ, Rockett KA, Kwiatkowski DP: In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat. Genetics 33, 469-475 (2003).
    • (2003) Nat. Genetics , vol.33 , pp. 469-475
    • Knight, J.C.1    Keating, B.J.2    Rockett, K.A.3    Kwiatkowski, D.P.4
  • 44
    • 0036181973 scopus 로고    scopus 로고
    • Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: The NOD mouse model of Type 1 diabetes
    • Eaves IA, Wicker LS, Ghandour G et al.: Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: The NOD mouse model of Type 1 diabetes. Genome Res. 12, 232-244 (2002).
    • (2002) Genome Res. , vol.12 , pp. 232-244
    • Eaves, I.A.1    Wicker, L.S.2    Ghandour, G.3
  • 45
    • 0034718159 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Alzheimer's disease: Pharmacogenomic target selection
    • 1502
    • Saunders AM, Trowers MK, Shimkets RA et al.: The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochem. Biophys. Acta 1502, 85-94 (2000).
    • (2000) Biochem. Biophys. Acta , pp. 85-94
    • Saunders, A.M.1    Trowers, M.K.2    Shimkets, R.A.3
  • 49
    • 24844457372 scopus 로고    scopus 로고
    • Differential brain atrophy profile associated with the APOE genotype in the Spanish population
    • 6th International Conference on Stroke and 3rd Conference of the Mediterranean Stroke Society, Monte Carlo, Monaco
    • Etcheverría I, Amado L, Pichel V, Cacabelos R: Differential brain atrophy profile associated with the APOE genotype in the Spanish population 6th International Conference on Stroke and 3rd Conference of the Mediterranean Stroke Society, Monte Carlo, Monaco, 47 (2003).
    • (2003) , vol.47
    • Etcheverría, I.1    Amado, L.2    Pichel, V.3    Cacabelos, R.4
  • 50
    • 0033403796 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion
    • Alvarez XA, Mouzo R, Pichel V et al.: Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity, and cerebral perfusion. Meth. Find. Exp. Clin. Pharmacol. 21, 633-644 (1999).
    • (1999) Meth. Find. Exp. Clin. Pharmacol. , vol.21 , pp. 633-644
    • Alvarez, X.A.1    Mouzo, R.2    Pichel, V.3
  • 51
    • 0034525674 scopus 로고    scopus 로고
    • Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: Effects on cognition, brain bioelectrical activity and cerebral hemodynamics
    • Alvarez XA, Pichel V, Pérez P et al.: Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Meth. Find. Exp. Clin. Pharmacol. 22, 585-594 (2000).
    • (2000) Meth. Find. Exp. Clin. Pharmacol. , vol.22 , pp. 585-594
    • Alvarez, X.A.1    Pichel, V.2    Pérez, P.3
  • 52
    • 4243303874 scopus 로고    scopus 로고
    • Age- and APOE-dependent cerebrovascular changes in the Spanish population
    • 6th International Conference on Stroke and 3rd Conference of the Mediterranean Stroke Society, Monte Carlo, Monaco
    • Etcheverría I, Amado L, Pichel V, Cacabelos R: Age- and APOE-dependent cerebrovascular changes in the Spanish population 6th International Conference on Stroke and 3rd Conference of the Mediterranean Stroke Society, Monte Carlo, Monaco, 32 (2003).
    • (2003) , vol.32
    • Etcheverría, I.1    Amado, L.2    Pichel, V.3    Cacabelos, R.4
  • 53
    • 0037227538 scopus 로고    scopus 로고
    • Increased brain β-amyloid load, phosphorylated tau, and risk of Alzheimer's disease associated with an intronic CYP46 polymorphism
    • Papassotiropoulos A, Streffer JR, Tsolaki M et al.: Increased brain β-amyloid load, phosphorylated tau, and risk of Alzheimer's disease associated with an intronic CYP46 polymorphism. Arch. Neurol. 60, 29-35 (2003).
    • (2003) Arch. Neurol. , vol.60 , pp. 29-35
    • Papassotiropoulos, A.1    Streffer, J.R.2    Tsolaki, M.3
  • 54
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease : The cholesterol connection
    • Puglielli L, Tanzi RE, Kovacs DM: Alzheimer's disease : the cholesterol connection. Nat. Neurosci. 6, 345-351 (2003).
    • (2003) Nat. Neurosci. , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 55
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer's disease as a vascular disorder
    • De la Torre JC: Alzheimer's disease as a vascular disorder. Stroke 33, 1152-1162 (2002).
    • (2002) Stroke , vol.33 , pp. 1152-1162
    • De la Torre, J.C.1
  • 56
    • 0036447681 scopus 로고    scopus 로고
    • Vascular basis of Alzheimer's pathogenesis
    • De la Torre JC: Vascular basis of Alzheimer's pathogenesis. Ann. NY Acad. Sci. 977, 196-215 (2002)
    • (2002) Ann. NY Acad. Sci. , vol.977 , pp. 196-215
    • De la Torre, J.C.1
  • 58
    • 0041864420 scopus 로고    scopus 로고
    • The histamine-cytokine network in Alzheimer's disease: Etiopathogenic and pharmacogenomic implications
    • Mizuno Y, Fisher A, Hanin I (Eds), Pergamon Press, New York, USA Advances in Behavioral Biology
    • Cacabelos R: The histamine-cytokine network in Alzheimer's disease: Etiopathogenic and pharmacogenomic implications. In: Mapping Progress of Alzheimer's and Parkinson's diseases. Advances in Behavioral Biology (Vol 51). Mizuno Y, Fisher A, Hanin I (Eds), Pergamon Press, New York, USA 59-64 (2002).
    • (2002) Mapping Progress of Alzheimer's and Parkinson's Diseases , vol.51 , pp. 59-64
    • Cacabelos, R.1
  • 59
    • 0037709474 scopus 로고    scopus 로고
    • The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain
    • Williamson KS, Gabbita SP, Mou S et al.: The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide 6, 221-227 (2002).
    • (2002) Nitric Oxide , vol.6 , pp. 221-227
    • Williamson, K.S.1    Gabbita, S.P.2    Mou, S.3
  • 60
    • 0036753272 scopus 로고    scopus 로고
    • Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
    • Butterfield DA, Castegna A, Lauderback CM, Drake J: Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol. Aging 23, 655-664 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 655-664
    • Butterfield, D.A.1    Castegna, A.2    Lauderback, C.M.3    Drake, J.4
  • 61
    • 0036272650 scopus 로고    scopus 로고
    • Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
    • Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA: Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J. Neurochem. 80, 91-100 (2002).
    • (2002) J. Neurochem. , vol.80 , pp. 91-100
    • Casley, C.S.1    Canevari, L.2    Land, J.M.3    Clark, J.B.4    Sharpe, M.A.5
  • 62
    • 0036752024 scopus 로고    scopus 로고
    • APOE and the regulation of microglial nitric oxide production: A link between genetic risk and oxidative stress
    • Colton CA, Brown CM, Cook D et al.: APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol. Aging 23, 777-785 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 777-785
    • Colton, C.A.1    Brown, C.M.2    Cook, D.3
  • 63
    • 0037023277 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and argininosuccinate synthase: Coinduction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro
    • Haas J, Storch-Hagenlocher B, Biessmann A, Wildemann B: Inducible nitric oxide synthase and argininosuccinate synthase: coinduction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro. Neurosci. Lett. 322, 121-125 (2002).
    • (2002) Neurosci. Lett. , vol.322 , pp. 121-125
    • Haas, J.1    Storch-Hagenlocher, B.2    Biessmann, A.3    Wildemann, B.4
  • 65
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • Evans WE, McLeod HL: Pharmacogenomics - drug disposition, drug targets, and side effects. N. Engl. J. Med. 348, 538-549 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 66
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • Weinshilboum R: Inheritance and drug response. N. Engl. J. Med. 348, 529-537 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 67
    • 0037068964 scopus 로고    scopus 로고
    • Clinical importance of the cytochromes P450
    • Nebert DW, Russell DW: Clinical importance of the cytochromes P450. Lancet 360, 1155-1162 (2002).
    • (2002) Lancet , vol.360 , pp. 1155-1162
    • Nebert, D.W.1    Russell, D.W.2
  • 68
    • 0034469337 scopus 로고    scopus 로고
    • Isolation, sequence and gentyping of the drug metabolizer CYP2D6 gene in the Colombian population
    • Isaza CA, Henao J, López AM, Cacabelos R: Isolation, sequence and gentyping of the drug metabolizer CYP2D6 gene in the Colombian population. Meth. Find. Exp. Clin. Pharmacol. 22, 695-705 (2000).
    • (2000) Meth. Find. Exp. Clin. Pharmacol. , vol.22 , pp. 695-705
    • Isaza, C.A.1    Henao, J.2    López, A.M.3    Cacabelos, R.4
  • 70
    • 0032921441 scopus 로고    scopus 로고
    • Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease
    • Poirier J: Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease. J. Psychiat. Neurosci. 24, 147-153 (1999).
    • (1999) J. Psychiat. Neurosci. , vol.24 , pp. 147-153
    • Poirier, J.1
  • 71
    • 0031943549 scopus 로고    scopus 로고
    • Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease
    • Farlow MR, Lahiri DK, Poirier J, Davignon J, Schneider L, Hui SL: Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology 50, 669-677 (1998).
    • (1998) Neurology , vol.50 , pp. 669-677
    • Farlow, M.R.1    Lahiri, D.K.2    Poirier, J.3    Davignon, J.4    Schneider, L.5    Hui, S.L.6
  • 72
    • 0034351513 scopus 로고    scopus 로고
    • The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimer's disease
    • Rigaud AS, Traykov L, Caputo L et al.: The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimer's disease. Eur. J. Neurol. 7, 255-258 (2000).
    • (2000) Eur. J. Neurol. , vol.7 , pp. 255-258
    • Rigaud, A.S.1    Traykov, L.2    Caputo, L.3
  • 74
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 76
    • 0036303818 scopus 로고    scopus 로고
    • Genetically engineered mouse models of neurodegenerative diseases
    • Wong PC, Cai H, Borchelt DR, Price DL: Genetically engineered mouse models of neurodegenerative diseases. Nat. Neurosci. 5, 633-639 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 633-639
    • Wong, P.C.1    Cai, H.2    Borchelt, D.R.3    Price, D.L.4
  • 77
    • 0037373633 scopus 로고    scopus 로고
    • Dying for a cause: Invertebrate genetics takes on human neurodegeneration
    • Driscoll M, Gerstbrein B: Dying for a cause: Invertebrate genetics takes on human neurodegeneration. Nat. Rev. Genet. 4, 181-194 (2003).
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 181-194
    • Driscoll, M.1    Gerstbrein, B.2
  • 78
    • 0035577779 scopus 로고    scopus 로고
    • Cerebrovascular structure and dementia: New drug targets
    • Atkinson J: Cerebrovascular structure and dementia: new drug targets. Trend Pharmacol. Sci. 22, 630-635 (2001).
    • (2001) Trend Pharmacol. Sci. , vol.22 , pp. 630-635
    • Atkinson, J.1
  • 79
    • 0035940943 scopus 로고    scopus 로고
    • A genomic-systems biology map for cardiovascular function
    • Stoll M, Cowley AW, Tonellato PJ et al.: A genomic-systems biology map for cardiovascular function. Science 294,1723-1726 (2001).
    • (2001) Science , vol.294 , pp. 1723-1726
    • Stoll, M.1    Cowley, A.W.2    Tonellato, P.J.3
  • 80
    • 0035860983 scopus 로고    scopus 로고
    • Complete genomic scree in Parkinson's disease. Evidence for multiple genes
    • Scott WK, Nance MA, Watts RL et al.: Complete genomic scree in Parkinson's disease. Evidence for multiple genes. JAMA 286, 2239-2244 (2001).
    • (2001) JAMA , vol.286 , pp. 2239-2244
    • Scott, W.K.1    Nance, M.A.2    Watts, R.L.3
  • 81
    • 0037177622 scopus 로고    scopus 로고
    • Influence of gene action across different time scales on behavior
    • Ben-Shahar Y, Robichon A, Sokolowski MB, Robinson GE: Influence of gene action across different time scales on behavior. Science 296, 741-744 (2002).
    • (2002) Science , vol.296 , pp. 741-744
    • Ben-Shahar, Y.1    Robichon, A.2    Sokolowski, M.B.3    Robinson, G.E.4
  • 82
    • 0035200177 scopus 로고    scopus 로고
    • Genes, brain and cognition
    • Plomin R, Kosslyn SM: Genes, brain and cognition. Nat. Neurosci. 4, 1153-1155 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 1153-1155
    • Plomin, R.1    Kosslyn, S.M.2
  • 83
    • 0035204137 scopus 로고    scopus 로고
    • Inducible, pharmacogenetic approaches to the study of learning and memory
    • Ohno M, Frankland PW, Chen AP, Costa RM, Silva AJ: Inducible, pharmacogenetic approaches to the study of learning and memory. Nat. Neurosci. 4, 1238-1243 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 1238-1243
    • Ohno, M.1    Frankland, P.W.2    Chen, A.P.3    Costa, R.M.4    Silva, A.J.5
  • 84
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer UA: Pharmacogenetics and adverse drug reactions. Lancet 356, 1667-1671 (2000).
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 85
    • 0035369825 scopus 로고    scopus 로고
    • Genetic susceptibility to adverse drug reactions
    • Pirmohamed M, Park BK: Genetic susceptibility to adverse drug reactions. Trend Pharmacol. Sci. 22, 298-305 (2001).
    • (2001) Trend Pharmacol. Sci. , vol.22 , pp. 298-305
    • Pirmohamed, M.1    Park, B.K.2
  • 86
    • 0035861049 scopus 로고    scopus 로고
    • Potencial role of pharmacogenomics in reducing adverse drug reactions. A systematic review
    • Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W: Potencial role of pharmacogenomics in reducing adverse drug reactions. A systematic review. JAMA 286, 2270-2279 (2001).
    • (2001) JAMA , vol.286 , pp. 2270-2279
    • Phillips, K.A.1    Veenstra, D.L.2    Oren, E.3    Lee, J.K.4    Sadee, W.5
  • 87
    • 0035254858 scopus 로고    scopus 로고
    • Clinical pharmacogenomics: Applications in pharmaceutical R&D
    • Norton RM: Clinical pharmacogenomics: applications in pharmaceutical R&D. DDT 6, 180-185 (2001).
    • (2001) DDT , vol.6 , pp. 180-185
    • Norton, R.M.1
  • 88
    • 0034022213 scopus 로고    scopus 로고
    • The use of single-nucleotide polymorphism maps in pharmacogenomics
    • McCarthy JJ, Hilfiker R: The use of single-nucleotide polymorphism maps in pharmacogenomics. Nat. Biotech. 18, 505-508 (2000).
    • (2000) Nat. Biotech. , vol.18 , pp. 505-508
    • McCarthy, J.J.1    Hilfiker, R.2
  • 89
    • 0035576439 scopus 로고    scopus 로고
    • Viral-based gene transfer to the mammalian CNS for functional genomic studies
    • Janson CG, McPhee SWJ, Leone P, Freese A, During MJ: Viral-based gene transfer to the mammalian CNS for functional genomic studies. Trend Neurosci. 24, 706-712 (2001).
    • (2001) Trend Neurosci. , vol.24 , pp. 706-712
    • Janson, C.G.1    McPhee, S.W.J.2    Leone, P.3    Freese, A.4    During, M.J.5
  • 90
    • 0033780104 scopus 로고    scopus 로고
    • How many diseases does it take to map a gene with SNPs?
    • Weiss KM, Terwilliger JD: How many diseases does it take to map a gene with SNPs? Nat. Genet. 26, 151-157 (2000).
    • (2000) Nat. Genet. , vol.26 , pp. 151-157
    • Weiss, K.M.1    Terwilliger, J.D.2
  • 91
    • 0037514257 scopus 로고    scopus 로고
    • 1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer's disease
    • 1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer's disease. JAMA 289, 2094-2103 (2003).
    • (2003) JAMA , vol.289 , pp. 2094-2103
    • Sunderland, T.1    Linker, G.2    Mirza, N.3
  • 92
    • 0036230086 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group
    • Shoji M, Matsubara E, Murakani T et al.: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol. Aging 23, 363-370 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 363-370
    • Shoji, M.1    Matsubara, E.2    Murakani, T.3
  • 93
    • 0035283058 scopus 로고    scopus 로고
    • Human morbid genetics revisited: Relevance of epigenetics
    • Petronis A: Human morbid genetics revisited: relevance of epigenetics. Trend. Genet. 17, 142-146 (2001).
    • (2001) Trend. Genet. , vol.17 , pp. 142-146
    • Petronis, A.1
  • 94
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A: Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33, 245-254 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 95
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • Soto C: Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci. 4, 49-60 (2003).
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 49-60
    • Soto, C.1
  • 96
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F, Hodgson JG, Eden A et al.: Induction of tumors in mice by genomic hypomethylation. Science 300, 489-492 (2003).
    • (2003) Science , vol.300 , pp. 489-492
    • Gaudet, F.1    Hodgson, J.G.2    Eden, A.3
  • 97
    • 0037379626 scopus 로고    scopus 로고
    • Between genotype and phenotype: Protein chaperones and evolvability
    • Rutherford SL: Between genotype and phenotype: Protein chaperones and evolvability. Nat. Rev. Genet. 4, 263-274 (2003).
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 263-274
    • Rutherford, S.L.1
  • 98
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • Kayed R, Head E, Thompson JL et al.: Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489 (2003).
    • (2003) Science , vol.300 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3
  • 99
    • 0036789017 scopus 로고    scopus 로고
    • Serpinopathies and the conformational dementias
    • Lomas DA, Carrell RW: Serpinopathies and the conformational dementias. Nat. Rev. Genet. 3, 759-768 (2002).
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 759-768
    • Lomas, D.A.1    Carrell, R.W.2
  • 100
    • 0037041420 scopus 로고    scopus 로고
    • Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
    • Bucciantini M, Giannoni E, Chiti F et al.: Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416, 507-511 (2002).
    • (2002) Nature , vol.416 , pp. 507-511
    • Bucciantini, M.1    Giannoni, E.2    Chiti, F.3
  • 101
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    • Lewis J, Dickson DW, Lin W-L et al.: Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293, 1487-1491 (2001).
    • (2001) Science , vol.293 , pp. 1487-1491
    • Lewis, J.1    Dickson, D.W.2    Lin, W.-L.3
  • 102
    • 0034992339 scopus 로고    scopus 로고
    • Tau and transgenic animal models
    • Götz J: Tau and transgenic animal models. Brain Res. Rev. 35, 266-286 (2001).
    • (2001) Brain Res. Rev. , vol.35 , pp. 266-286
    • Götz, J.1
  • 103
    • 0037453510 scopus 로고    scopus 로고
    • Assembly of cell regulatory systems through protein interaction domains
    • Pawson T, Nash P: Assembly of cell regulatory systems through protein interaction domains. Science 300, 445-453 (2003).
    • (2003) Science , vol.300 , pp. 445-453
    • Pawson, T.1    Nash, P.2
  • 104
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • Botstein D, Risch N: Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet. 33, 228-237 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 228-237
    • Botstein, D.1    Risch, N.2
  • 105
    • 0037370373 scopus 로고    scopus 로고
    • Proteomics: The first decade and beyond
    • Patterson SD, Aebersold RH: Proteomics: the first decade and beyond. Nat. Genet. 33, 311-323 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 311-323
    • Patterson, S.D.1    Aebersold, R.H.2
  • 106
    • 0037370478 scopus 로고    scopus 로고
    • Bioinformatics in the post-sequence era
    • Kanehisa M, Bork P: Bioinformatics in the post-sequence era. Nat. Genet. 33, 305-310 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 305-310
    • Kanehisa, M.1    Bork, P.2
  • 107
    • 0042011475 scopus 로고    scopus 로고
    • DNA microarrays: Translation of the genome from laboratory to clinic
    • Geschwind DH: DNA microarrays: translation of the genome from laboratory to clinic. Lancet Neurol. 2, 275-282 (2003).
    • (2003) Lancet Neurol. , vol.2 , pp. 275-282
    • Geschwind, D.H.1
  • 108
    • 0036739330 scopus 로고    scopus 로고
    • Microarrays in pharmacogenomcis-advances and future promise
    • Chicurel ME, Dalma-Weiszhausz DD: Microarrays in pharmacogenomcis-advances and future promise. Pharmacogenomcis 3, 589-601 (2002).
    • (2002) Pharmacogenomcis , vol.3 , pp. 589-601
    • Chicurel, M.E.1    Dalma-Weiszhausz, D.D.2
  • 109
    • 0035576893 scopus 로고    scopus 로고
    • Gene therapy against neurological insults: Sparing neurons versus sparing function
    • Dumas TC, Sapolsky RM: Gene therapy against neurological insults: sparing neurons versus sparing function. Trend Neurosci. 24, 695-700 (2001).
    • (2001) Trend Neurosci. , vol.24 , pp. 695-700
    • Dumas, T.C.1    Sapolsky, R.M.2
  • 110
    • 0035576894 scopus 로고    scopus 로고
    • Neuroprotective peptide drug delivery and development: Potential new therapeutics
    • Gozes I: Neuroprotective peptide drug delivery and development: potential new therapeutics. Trend Neurosci. 24, 700-705 (2001).
    • (2001) Trend Neurosci. , vol.24 , pp. 700-705
    • Gozes, I.1
  • 111
    • 0035860969 scopus 로고    scopus 로고
    • Clinical proteomics. Personalized molecular medicine
    • Liotta LA, Kohn EC, Petriconi EF: Clinical proteomics. Personalized molecular medicine. JAMA 286, 2211-2214 (2001).
    • (2001) JAMA , vol.286 , pp. 2211-2214
    • Liotta, L.A.1    Kohn, E.C.2    Petriconi, E.F.3
  • 112
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL et al.: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41-49 (2002).
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 113
    • 0036234835 scopus 로고    scopus 로고
    • Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons
    • Song H, Stevens CF, Gage FH: Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nature Neurosci. 5, 438-445 (2002).
    • (2002) Nature Neurosci. , vol.5 , pp. 438-445
    • Song, H.1    Stevens, C.F.2    Gage, F.H.3
  • 114
    • 0035861047 scopus 로고    scopus 로고
    • Gene expression profile analysis by DNA microarrays. Promise and pitfalls
    • King HC, Sinha AA: Gene expression profile analysis by DNA microarrays. Promise and pitfalls. JAMA 286, 2280-2288 (2001).
    • (2001) JAMA , vol.286 , pp. 2280-2288
    • King, H.C.1    Sinha, A.A.2
  • 115
    • 0035861004 scopus 로고    scopus 로고
    • Implications of the human genome for understanding human biology and medicine
    • Subramanian G, Adams MD, Venter JC, Broder S: Implications of the human genome for understanding human biology and medicine. JAMA 286, 2296-2307 (2001).
    • (2001) JAMA , vol.286 , pp. 2296-2307
    • Subramanian, G.1    Adams, M.D.2    Venter, J.C.3    Broder, S.4
  • 116
    • 0037386720 scopus 로고    scopus 로고
    • Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs
    • Mandel S, Weinreb O, Youdim MBH: Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs. Trend Pharmacol. Sci. 24, 184-191 (2003).
    • (2003) Trend Pharmacol. Sci. , vol.24 , pp. 184-191
    • Mandel, S.1    Weinreb, O.2    Youdim, M.B.H.3
  • 117
    • 0038135191 scopus 로고    scopus 로고
    • Will the genomics revolution revolutionize psychiatry?
    • Merikangas KR, Risch N: Will the genomics revolution revolutionize psychiatry? Am. J. Psychiatry 160, 625-635 (2003).
    • (2003) Am. J. Psychiatry , vol.160 , pp. 625-635
    • Merikangas, K.R.1    Risch, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.