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This excellent paper looks at sequence diversity and LD between variants in 36 genes. In the light of their results, the authors advocate both genome-wide association studies coupled with more detailed characterisations of specific candidate genes as complementary approaches
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Am J Hum Genet
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This paper describes the sequence diversity of 106 human genes. The authors report differences in the rate of polymorphism for noncoding, degenerate and nondegenerate sites and comment on the implications for disease association studies
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Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
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The authors report the pattern and frequency of SNPs in 75 candidate human genes for blood-pressure homeostasis and hypertension. They show the strong role of natural selection in shaping human gene variation
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Tu I.P., Whittemore A.S. Power of association and linkage tests when the disease alleles are unobserved. Am J Hum Genet. 64:1999;641-649. This manuscript highlights the potential problems when relying on linkage disequilibrium between the disease variant and the genetic marker to detect any disease association.
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