메뉴 건너뛰기




Volumn 10, Issue 3, 2000, Pages 330-334

Strategies in complex disease mapping

Author keywords

[No Author keywords available]

Indexed keywords

ASTHMA; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DISEASE PREDISPOSITION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENE SEQUENCE; GENETIC POLYMORPHISM; HUMAN; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW;

EID: 0034068308     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00075-7     Document Type: Review
Times cited : (65)

References (65)
  • 1
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 2
    • 84984932946 scopus 로고    scopus 로고
    • Population genetics - making sense out of sequence
    • Chakravarti A. Population genetics - making sense out of sequence. Nat Genet. 21:1999;56-60.
    • (1999) Nat Genet , vol.21 , pp. 56-60
    • Chakravarti, A.1
  • 3
    • 0030688004 scopus 로고    scopus 로고
    • Variations on a theme: Cataloguing human DNA sequence variation
    • Collins F.S., Guyer M.S., Charkravarti A. Variations on a theme: cataloguing human DNA sequence variation. Science. 278:1997;1580-1581.
    • (1997) Science , vol.278 , pp. 1580-1581
    • Collins, F.S.1    Guyer, M.S.2    Charkravarti, A.3
  • 4
    • 0039050424 scopus 로고    scopus 로고
    • Multifactorial diseases: Ancient gene polymorphism at quantitative trait loci and a legacy of survival during our evolution
    • C.R. Scriver, A.L. Beaudet, W.S. Sly, D.L. Valle, B. Vogelstein, & B. Childs. New York: McGraw-Hill
    • Todd J.A. Multifactorial diseases: ancient gene polymorphism at quantitative trait loci and a legacy of survival during our evolution. Scriver C.R., Beaudet A.L., Sly W.S., Valle D.L., Vogelstein B., Childs B. The Metabolic and Molecular Basis of Inherited Disease. 2000;McGraw-Hill, New York.
    • (2000) The Metabolic and Molecular Basis of Inherited Disease
    • Todd, J.A.1
  • 7
    • 0003735823 scopus 로고    scopus 로고
    • HLA susceptibility to type 1 diabetes: Methods and mechanisms
    • M.J. Browning, & A.J. McMichael. Oxford: BIOS Scientific Publishers
    • Cucca F., Todd J.A. HLA susceptibility to type 1 diabetes: methods and mechanisms. Browning M.J., McMichael A.J. HLA and MHC: Genes, Molecules and Function. 1996;383-406 BIOS Scientific Publishers, Oxford.
    • (1996) HLA and MHC: Genes, Molecules and Function , pp. 383-406
    • Cucca, F.1    Todd, J.A.2
  • 8
    • 0032403973 scopus 로고    scopus 로고
    • Linkage disequilibrium mapping of complex disease: Fantasy or reality?
    • Terwilliger J.D., Weiss K.M. Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr Opin Biotechnol. 9:1998;578-594.
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 578-594
    • Terwilliger, J.D.1    Weiss, K.M.2
  • 9
    • 0032707163 scopus 로고    scopus 로고
    • Population choice in mapping genes for complex diseases
    • An informative review describing the two main models of complex disease and potential of populations with different demographies when mapping complex disease genes
    • Wright A.F., Carothers A.D., Pirastu M. Population choice in mapping genes for complex diseases. Nat Genet. 23:1999;397-404. An informative review describing the two main models of complex disease and potential of populations with different demographies when mapping complex disease genes.
    • (1999) Nat Genet , vol.23 , pp. 397-404
    • Wright, A.F.1    Carothers, A.D.2    Pirastu, M.3
  • 10
    • 0033017022 scopus 로고    scopus 로고
    • Deafness linked to DFNA2: One locus but how many genes?
    • This short correspondence highlights the complex locus heterogeneity seen in a Mendelian autosomal dominant disorder, in which at least two independent disease genes map to one linked chromosomal region. Multiple susceptibility genes may well account for the linkage seen in chromosomal regions implicated in complex disease
    • Van Hauwe P., Coucke P.J., Declau F., Kunst H., Ensink R.J., Marres H.A., Cremers C.W.R.J., Djelantik B., Smith S.D., Kelley P.et al. Deafness linked to DFNA2: one locus but how many genes? Nat Genet. 21:1999;263. This short correspondence highlights the complex locus heterogeneity seen in a Mendelian autosomal dominant disorder, in which at least two independent disease genes map to one linked chromosomal region. Multiple susceptibility genes may well account for the linkage seen in chromosomal regions implicated in complex disease.
    • (1999) Nat Genet , vol.21 , pp. 263
    • Van Hauwe, P.1    Coucke, P.J.2    Declau, F.3    Kunst, H.4    Ensink, R.J.5    Marres, H.A.6    Cremers, C.W.R.J.7    Djelantik, B.8    Smith, S.D.9    Kelley, P.10
  • 11
    • 0032928542 scopus 로고    scopus 로고
    • Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
    • Using a method that exploits potential interactions between susceptibility loci, this group demonstrates additional evidence for two putative susceptibility genes involved in type 2 diabetes
    • Cox N.J., Frigge M., Nicolae D.L., Concannon P., Hanis C.L., Bell G.I., Kong A. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet. 21:1999;213-215. Using a method that exploits potential interactions between susceptibility loci, this group demonstrates additional evidence for two putative susceptibility genes involved in type 2 diabetes.
    • (1999) Nat Genet , vol.21 , pp. 213-215
    • Cox, N.J.1    Frigge, M.2    Nicolae, D.L.3    Concannon, P.4    Hanis, C.L.5    Bell, G.I.6    Kong, A.7
  • 13
    • 0033071177 scopus 로고    scopus 로고
    • Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods
    • Xiong M., Jin L. Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods. Am J Hum Genet. 64:1999;629-640.
    • (1999) Am J Hum Genet , vol.64 , pp. 629-640
    • Xiong, M.1    Jin, L.2
  • 16
    • 0033042156 scopus 로고    scopus 로고
    • Efficient approach to unique single-nucleotide polymorphism discovery
    • Taillon-Miller P.P.E., Kwok P.Y. Efficient approach to unique single-nucleotide polymorphism discovery. Genome Res. 9:1999;499-505.
    • (1999) Genome Res , vol.9 , pp. 499-505
    • Taillon-Miller, P.P.E.1    Kwok, P.Y.2
  • 18
    • 0033018816 scopus 로고    scopus 로고
    • Reliable identification of large numbers of candidate SNPs from public EST data
    • This group uses existing sequence data as a resource for identifying SNPs, a potentially cheaper method of identifying polymorphisms within coding regions of genes
    • Buetow K.H., Edmonson M.N., Cassidy A.B. Reliable identification of large numbers of candidate SNPs from public EST data. Nat Genet. 21:1999;323-325. This group uses existing sequence data as a resource for identifying SNPs, a potentially cheaper method of identifying polymorphisms within coding regions of genes.
    • (1999) Nat Genet , vol.21 , pp. 323-325
    • Buetow, K.H.1    Edmonson, M.N.2    Cassidy, A.B.3
  • 19
    • 0031697439 scopus 로고    scopus 로고
    • Reading bits of genetic information: Methods for single-nucleotide polymorphism analysis
    • This manuscript gives an overview explaining why SNPs are so popular and describes new technologies under development that will hopefully allow these markers to be typed on a huge scale
    • Landegren U., Nilsson M., Kwok P.Y. Reading bits of genetic information: methods for single-nucleotide polymorphism analysis. Genome Res. 8:1998;769-776. This manuscript gives an overview explaining why SNPs are so popular and describes new technologies under development that will hopefully allow these markers to be typed on a huge scale.
    • (1998) Genome Res , vol.8 , pp. 769-776
    • Landegren, U.1    Nilsson, M.2    Kwok, P.Y.3
  • 20
    • 0032848965 scopus 로고    scopus 로고
    • Mutational analysis using oligonucleotide microarrays
    • Hacia J.G., Collins F.S. Mutational analysis using oligonucleotide microarrays. J Med Genet. 36:1999;730-736.
    • (1999) J Med Genet , vol.36 , pp. 730-736
    • Hacia, J.G.1    Collins, F.S.2
  • 23
    • 0030810721 scopus 로고    scopus 로고
    • Minisequencing: A specific tool for DNA analysis and diagnostics on oligonucleotide arrays
    • Pastinen T., Kurg A., Metspalu A., Peltonen L., Syvanen A.C. Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays. Genome Res. 7:1997;606-614.
    • (1997) Genome Res , vol.7 , pp. 606-614
    • Pastinen, T.1    Kurg, A.2    Metspalu, A.3    Peltonen, L.4    Syvanen, A.C.5
  • 24
    • 0033039497 scopus 로고    scopus 로고
    • Prospects for whole-genome linkage disequilibrium mapping of common disease genes
    • In this paper, Krugylak estimates the amount of 'useful' LD that is likely to occur between common alleles in the general population. If his conclusions are correct it paints a bleak picture, at least in the foreseeable future, for genome-wide association mapping
    • Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 22:1999;139-144. In this paper, Krugylak estimates the amount of 'useful' LD that is likely to occur between common alleles in the general population. If his conclusions are correct it paints a bleak picture, at least in the foreseeable future, for genome-wide association mapping.
    • (1999) Nat Genet , vol.22 , pp. 139-144
    • Kruglyak, L.1
  • 25
    • 84984932472 scopus 로고    scopus 로고
    • Exploring the new world of the genome with DNA microarrays
    • Brown P.O., Botstein D. Exploring the new world of the genome with DNA microarrays. Nat Genet. 21:1999;33-37.
    • (1999) Nat Genet , vol.21 , pp. 33-37
    • Brown, P.O.1    Botstein, D.2
  • 28
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L., Diehl N., Brennen M.B., Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med. 5:1999;1066-1070.
    • (1999) Nat Med , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennen, M.B.3    Hochgeschwender, U.4
  • 29
    • 0033358728 scopus 로고    scopus 로고
    • Sequence diversity in 36 candidate genes for cardiovascular disorders
    • This excellent paper looks at sequence diversity and LD between variants in 36 genes. In the light of their results, the authors advocate both genome-wide association studies coupled with more detailed characterisations of specific candidate genes as complementary approaches
    • Cambien F., Poirier O., Nicaud V., Herrmann S.M., Mallet C., Ricard S., Behague I., Hallet V., Blanc H., Loukaci V.et al. Sequence diversity in 36 candidate genes for cardiovascular disorders. Am J Hum Genet. 65:1999;183-191. This excellent paper looks at sequence diversity and LD between variants in 36 genes. In the light of their results, the authors advocate both genome-wide association studies coupled with more detailed characterisations of specific candidate genes as complementary approaches.
    • (1999) Am J Hum Genet , vol.65 , pp. 183-191
    • Cambien, F.1    Poirier, O.2    Nicaud, V.3    Herrmann, S.M.4    Mallet, C.5    Ricard, S.6    Behague, I.7    Hallet, V.8    Blanc, H.9    Loukaci, V.10
  • 30
    • 0032991552 scopus 로고    scopus 로고
    • Characterization of single-nucleotide polymorphisms in coding regions of human genes
    • This paper describes the sequence diversity of 106 human genes. The authors report differences in the rate of polymorphism for noncoding, degenerate and nondegenerate sites and comment on the implications for disease association studies
    • Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Lane C.R., Lim E.P., Kalayanaraman N., Nemesh J.et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 22:1999;231-238. This paper describes the sequence diversity of 106 human genes. The authors report differences in the rate of polymorphism for noncoding, degenerate and nondegenerate sites and comment on the implications for disease association studies.
    • (1999) Nat Genet , vol.22 , pp. 231-238
    • Cargill, M.1    Altshuler, D.2    Ireland, J.3    Sklar, P.4    Ardlie, K.5    Patil, N.6    Lane, C.R.7    Lim, E.P.8    Kalayanaraman, N.9    Nemesh, J.10
  • 31
    • 0032990407 scopus 로고    scopus 로고
    • Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
    • The authors report the pattern and frequency of SNPs in 75 candidate human genes for blood-pressure homeostasis and hypertension. They show the strong role of natural selection in shaping human gene variation
    • Halushka M.K., Fan J.B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 22:1999;239-247. The authors report the pattern and frequency of SNPs in 75 candidate human genes for blood-pressure homeostasis and hypertension. They show the strong role of natural selection in shaping human gene variation.
    • (1999) Nat Genet , vol.22 , pp. 239-247
    • Halushka, M.K.1    Fan, J.B.2    Bentley, K.3    Hsie, L.4    Shen, N.5    Weder, A.6    Cooper, R.7    Lipshutz, R.8    Chakravarti, A.9
  • 33
    • 0032906340 scopus 로고    scopus 로고
    • Sequence variation in the human angiotensin converting enzyme
    • Rieder M.J., Taylor S.L., Clark A.G., Nickerson D.A. Sequence variation in the human angiotensin converting enzyme. Nat Genet. 22:1999;59-62.
    • (1999) Nat Genet , vol.22 , pp. 59-62
    • Rieder, M.J.1    Taylor, S.L.2    Clark, A.G.3    Nickerson, D.A.4
  • 34
    • 0031747186 scopus 로고    scopus 로고
    • Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster
    • Long A.D., Lyman R.F., Langley C.H., Mackay T.F. Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster. Genetics. 149:1998;999-1017.
    • (1998) Genetics , vol.149 , pp. 999-1017
    • Long, A.D.1    Lyman, R.F.2    Langley, C.H.3    Mackay, T.F.4
  • 36
    • 0032231325 scopus 로고    scopus 로고
    • Maximum-likelihood expression of the transmission/disequilibrium test and power considerations
    • Abel L., Muller-Myhsok B. Maximum-likelihood expression of the transmission/disequilibrium test and power considerations. Am J Hum Genet. 63:1998;664-667.
    • (1998) Am J Hum Genet , vol.63 , pp. 664-667
    • Abel, L.1    Muller-Myhsok, B.2
  • 37
    • 0033073397 scopus 로고    scopus 로고
    • Power of association and linkage tests when the disease alleles are unobserved
    • This manuscript highlights the potential problems when relying on linkage disequilibrium between the disease variant and the genetic marker to detect any disease association
    • Tu I.P., Whittemore A.S. Power of association and linkage tests when the disease alleles are unobserved. Am J Hum Genet. 64:1999;641-649. This manuscript highlights the potential problems when relying on linkage disequilibrium between the disease variant and the genetic marker to detect any disease association.
    • (1999) Am J Hum Genet , vol.64 , pp. 641-649
    • Tu, I.P.1    Whittemore, A.S.2
  • 38
    • 0032530165 scopus 로고    scopus 로고
    • Tests and estimates of allelic association in complex inheritance
    • Morton N.E., Collins A. Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci USA. 95:1998;11389-11393.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11389-11393
    • Morton, N.E.1    Collins, A.2
  • 39
    • 0033365262 scopus 로고    scopus 로고
    • Linkage detection adaptive to linkage disequilibrium: The disequilibrium maximum-likelihood-binomial test for affected-sibship data
    • Huang J., Jiang Y. Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data. Am J Hum Genet. 65:1999;1741-1759.
    • (1999) Am J Hum Genet , vol.65 , pp. 1741-1759
    • Huang, J.1    Jiang, Y.2
  • 40
    • 0007525310 scopus 로고    scopus 로고
    • Mapping of complex traits by single-nucleotide polymorphisms
    • Zhao L.P., Aragaki C., Hsu L., Quiaoit F. Mapping of complex traits by single-nucleotide polymorphisms. Am J Hum Genet. 63:1998;225-240.
    • (1998) Am J Hum Genet , vol.63 , pp. 225-240
    • Zhao, L.P.1    Aragaki, C.2    Hsu, L.3    Quiaoit, F.4
  • 41
    • 0032952468 scopus 로고    scopus 로고
    • Freely associating
    • Editorial
    • Editorial: Freely associating. Nat Genet 1999, 22:1-2.
    • (1999) Nat Genet , vol.22 , pp. 1-2
  • 42
    • 0032514681 scopus 로고    scopus 로고
    • Linkage disequilibrium mapping in isolated populations: The example of Finland revisited
    • de la Chapelle A., Wright F.A. Linkage disequilibrium mapping in isolated populations: the example of Finland revisited. Proc Natl Acad Sci USA. 95:1998;12416-12423.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12416-12423
    • De La Chapelle, A.1    Wright, F.A.2
  • 43
    • 0033573934 scopus 로고    scopus 로고
    • Genetic isolates: Separate but equal?
    • Kruglyak L. Genetic isolates: separate but equal? Proc Natl Acad Sci USA. 96:1999;1170-1172.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1170-1172
    • Kruglyak, L.1
  • 44
    • 0033918564 scopus 로고    scopus 로고
    • The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes
    • •] that founder populations such as the Finns may not provide a significant advantage for linkage disequilibrium mapping of common disease genes
    • •] that founder populations such as the Finns may not provide a significant advantage for linkage disequilibrium mapping of common disease genes.
    • (2000) Nat Genet
    • Eaves, I.A.1    Merriman, T.R.2    Barber, R.A.3    Nutland, S.4    Tuomilehto-Wolf, E.5    Cucca, F.6    Todd, J.A.7
  • 45
    • 0030667521 scopus 로고    scopus 로고
    • Demographic history and linkage disequilibrium in human populations
    • Laan M., Paabo S. Demographic history and linkage disequilibrium in human populations. Nat Genet. 17:1997;435-438.
    • (1997) Nat Genet , vol.17 , pp. 435-438
    • Laan, M.1    Paabo, S.2
  • 46
    • 0024209791 scopus 로고
    • Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci
    • Chakraborty R., Weiss K.M. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc Natl Acad Sci USA. 85:1988;9119-9123.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9119-9123
    • Chakraborty, R.1    Weiss, K.M.2
  • 47
    • 0032231748 scopus 로고    scopus 로고
    • Mapping genes that underlie ethnic differences in disease risk: Methods for detecting linkage in admixed populations, by conditioning on parental admixture
    • McKeigue P.M. Mapping genes that underlie ethnic differences in disease risk: methods for detecting linkage in admixed populations, by conditioning on parental admixture. Am J Hum Genet. 63:1998;241-251.
    • (1998) Am J Hum Genet , vol.63 , pp. 241-251
    • McKeigue, P.M.1
  • 48
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E., Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 11:1995;241-247.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 49
    • 0030869377 scopus 로고    scopus 로고
    • What is significant in whole-genome linkage disequilibrium studies?
    • Kruglyak L. What is significant in whole-genome linkage disequilibrium studies? Am J Hum Genet. 61:1997;810-812.
    • (1997) Am J Hum Genet , vol.61 , pp. 810-812
    • Kruglyak, L.1
  • 50
    • 0032231299 scopus 로고    scopus 로고
    • Methods of linkage analysis - And the assumptions underlying them
    • Elston R.C. Methods of linkage analysis - and the assumptions underlying them. Am J Hum Genet. 63:1998;931-934.
    • (1998) Am J Hum Genet , vol.63 , pp. 931-934
    • Elston, R.C.1
  • 51
    • 0033364957 scopus 로고    scopus 로고
    • On a randomization procedure in linkage analysis
    • Zhao H., Merikangas K.R., Kidd K.K. On a randomization procedure in linkage analysis. Am J Hum Genet. 65:1999;1449-1456.
    • (1999) Am J Hum Genet , vol.65 , pp. 1449-1456
    • Zhao, H.1    Merikangas, K.R.2    Kidd, K.K.3
  • 53
    • 0031831322 scopus 로고    scopus 로고
    • Sometimes it's hot, sometimes it's not
    • Lernmark A., Ott J. Sometimes it's hot, sometimes it's not. Nat Genet. 19:1998;213-214.
    • (1998) Nat Genet , vol.19 , pp. 213-214
    • Lernmark, A.1    Ott, J.2
  • 54
    • 0032827782 scopus 로고    scopus 로고
    • The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
    • This paper examines the power of different association-based analyses to implicate SNPs contributing to disease susceptibility in candidate gene regions. Although based on simplistic population models, the authors make intelligent comments about experimental design concerning sample size, use of statistics, and SNP density
    • Long A.D., Langley C.H. The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. Genome Res. 9:1999;720-721. This paper examines the power of different association-based analyses to implicate SNPs contributing to disease susceptibility in candidate gene regions. Although based on simplistic population models, the authors make intelligent comments about experimental design concerning sample size, use of statistics, and SNP density.
    • (1999) Genome Res , vol.9 , pp. 720-721
    • Long, A.D.1    Langley, C.H.2
  • 55
    • 0033358661 scopus 로고    scopus 로고
    • Replication of linkage studies of complex traits: An examination of variation in location estimates
    • Roberts S.B., MacLean C.J., Neale M.C., Eaves L.J., Kendler K.S. Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet. 65:1999;876-884.
    • (1999) Am J Hum Genet , vol.65 , pp. 876-884
    • Roberts, S.B.1    MacLean, C.J.2    Neale, M.C.3    Eaves, L.J.4    Kendler, K.S.5
  • 56
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • Vyse T.J., Todd J.A. Genetic analysis of autoimmune disease. Cell. 85:1996;311-318.
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 58
    • 0033032379 scopus 로고    scopus 로고
    • Comparative genetics of type 1 diabetes and autoimmune disease: Common loci, common pathways?
    • Becker K.G. Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways? Diabetes. 48:1999;1353-1358.
    • (1999) Diabetes , vol.48 , pp. 1353-1358
    • Becker, K.G.1
  • 60
    • 0033486824 scopus 로고    scopus 로고
    • Localising quantitative trait loci in the NOD mouse model of Type 1 diabetes
    • A.N. Theofilopoulos. Basel: Karger. An informative review detailing the problems encountered when mapping a complex disease gene in the NOD mouse
    • Lyons P.A., Wicker L.S. Localising quantitative trait loci in the NOD mouse model of Type 1 diabetes. Theofilopoulos A.N. Genes and Genetics of Autoimmunity. 1999;208-225 Karger, Basel. An informative review detailing the problems encountered when mapping a complex disease gene in the NOD mouse.
    • (1999) Genes and Genetics of Autoimmunity , pp. 208-225
    • Lyons, P.A.1    Wicker, L.S.2
  • 61
    • 0024510601 scopus 로고
    • Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping
    • Todd J.A., Mijovic C., Fletcher J., Jenkins D., Bradwell A.R., Barnett A.H. Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature. 338:1989;587-589.
    • (1989) Nature , vol.338 , pp. 587-589
    • Todd, J.A.1    Mijovic, C.2    Fletcher, J.3    Jenkins, D.4    Bradwell, A.R.5    Barnett, A.H.6
  • 63
    • 0030838316 scopus 로고    scopus 로고
    • Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease
    • Schunkert H. Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J Mol Med. 75:1997;867-875.
    • (1997) J Mol Med , vol.75 , pp. 867-875
    • Schunkert, H.1
  • 65
    • 0032727199 scopus 로고    scopus 로고
    • Fine-mapping of an ancestral recombination breakpoint in DCP1
    • Using data generated from [33], this paper demonstrates that ancestral haplotype breakpoint mapping (see [4,61]), can eliminate the most 5′ end of the DCP1 gene from harbouring the variant causing variation in enzyme levels
    • Farrall M., Keavney B., McKenzie C., Delepine M., Matsuda F., Lathrop G.M. Fine-mapping of an ancestral recombination breakpoint in DCP1. Nat Genet. 23:1999;270-271. Using data generated from [33], this paper demonstrates that ancestral haplotype breakpoint mapping (see [4,61]), can eliminate the most 5′ end of the DCP1 gene from harbouring the variant causing variation in enzyme levels.
    • (1999) Nat Genet , vol.23 , pp. 270-271
    • Farrall, M.1    Keavney, B.2    McKenzie, C.3    Delepine, M.4    Matsuda, F.5    Lathrop, G.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.