Gene expression profile analysis by DNA microarrays: Promise and pitfalls

JAMA

Volumn 286, Issue 18, 2001, Pages 2280-2288

  King, Hadley C ^a   Sinha, Animesh A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ANALYTIC METHOD; ANATOMY; CELL POPULATION; CHROMOSOME MICRODISSECTION; DATA ANALYSIS; DNA HYBRIDIZATION; DNA MICROARRAY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INDIVIDUALITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SAMPLE; SIGNAL NOISE RATIO; STATISTICAL ANALYSIS; TISSUE SECTION;

EID: 0035861047     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.286.18.2280     Document Type: Review

References (70)

1. The sequence of the human genome
2. The future is function
3. The new genomics
4. Differential display of eukaryotic messenger RNA by means of the porymerase chain reaction
5. Serial analysis of gene expression
6. Expression monitoring by hybridization to high-density origonucleotide arrays
7. A new dimension for the human genome project
8. Cytochrome P4502E1 porymorphism in gastric cancer in Brazil
9. Isolation of rat pgp3 cDNA
10. Loss of heterozygosity in normal tissue adjacent to breast carcinomas
11. Barrett's esophagus
12. Allerespecific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma
13. Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human 'de novo' colorectal carcinomas
14. The genetics of cancer - A 3D model
15. Identification of differentially expressed genes in human prostate cancer using subtraction and microarray
16. Microarray-based expression profiting in prostate tumors
17. Prostate tumours from an Asian population
18. Ki-ras point mutation and p53 expression in human pancreatic cancer
19. Racial differences in the androgen/androgen receptor pathway in prostate cancer
20. Expression of the endostatin gene in epitherial ovarian cancer
21. Recent advances in melanoma research
22. Gene expression profiling of rymphomas
23. A study on C-erbB2, nm23 and p53 expressions in epithelial ovarian cancer and their clinicar significance
24. Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor
25. Association between expression of the MRP3 gene and exposure to platinum drugs in lung cancer
26. Molecular classification of cancer
27. Classification and diagnostic prediction of cancers using gene expression profiting and artificial neural networks
28. Recursive partitioning for tumor classification with gene expression microarray data
29. Molecular classification of cutaneous malignant melanoma by gene expression profiling
30. Analysis of gene expression profiles in normar and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer
31. Systematic variation in gene expression patterns in human cancer ceil lines
32. Altered patterns of gene expression in response to myocardial infarction
33. Leading the way using microarray
34. Laser capture microdissection
35. Laser capture microdissection
36. In vivo gene expression profile anarysis of human breast cancer progression
37. Effects of ethanol and paraformaldehyde on RNA yield and quality
38. Small-sample total RNA purification
39. The application of DNA microarrays in gene expression anarysis
40. Gene expression studies using microarrays
41. Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after lasercapture microdissection of tumor tissues and normal epitheria
42. The "chip" as a specific genetic tool
43. A genome-wide transcriptional analysis of the mitotic cell cycle
44. Cellular clocks and oscillators
45. Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes
46. Computational methods for the identification of differential and coordinated gene expression
47. Comparison of normal human skin gene expression using cDNA microarrays
48. Normalization strategies for cDNA microarrays
49. Importance of replication in microarray gene expression studies
50. Analyzing high-density origonudeotide gene expression array data
51. Cluster analysis and display of genome-wide expression patterns
52. Gene expression informatics - It's all in your mine
53. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
54. Expression profiling
55. Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays
56. Quantitative assessment of DNA microarrays-comparison with Northern blot analyses
57. Options available - From start to finish - For obtaining expression data by microarray
58. Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones
59. Interaction of Pseudomonas aeruginosa with epithelial cells
60. Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray
61. Identification of differentially expressed genes from ovarian cancer cells by MICROMAX cDNA microarray system
62. Quantitative real-time polymerase chain reaction for the core facility using TaqMan and the Perkin-Elmer/Applied Biosystems Division 7700 sequence detector
63. Qualitative and quantitative determination of mRNA
64. Quantitative PCR
65. Functional characterization of the S cerevisiae genome by gene deletion and parallel analysis
66. Proteomics gears up
67. Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays
68. Coexpression of CD40 and CD40 ligand in cutaneous T-cell lymphoma (mycosis fungoides)
69. Can researchers find recipe for proteins and chips?