-
1
-
-
0032522873
-
Incidence of adverse drug reactions in hospitalized patients - A meta-analysis of prospective studies
-
(1998)
J. Am. Med. Assoc.
, vol.279
, pp. 1200-1205
-
-
Lazarou, J.1
-
2
-
-
0034720005
-
Adverse drug reactions in hospitalized patients: A critique of a meta-analysis
-
(2000)
Medgenmed.
, vol.6
-
-
Kvasz, M.1
-
4
-
-
0029066463
-
Incidence of adverse drug events and potential adverse drug events - Implications for prevention
-
(1995)
J. Am. Med. Assoc.
, vol.274
, pp. 29-34
-
-
Bates, D.W.1
-
7
-
-
0032748555
-
Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?
-
(1999)
Clin. Genet.
, vol.56
, pp. 247-258
-
-
Nebert, D.W.1
-
11
-
-
0031719374
-
The role of drug disposition in drug hypersensitivity: A chemical, molecular and clinical perspective
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 969-988
-
-
Park, B.K.1
-
13
-
-
0034638766
-
Pharmacogenetics and adverse drug reactions
-
(2000)
Lancet
, vol.356
, pp. 1667-1671
-
-
Meyer, U.A.1
-
14
-
-
0033939932
-
A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: Association with tardive dyskinesia in schizophrenia
-
(2000)
Mol. Psychiatry
, vol.5
, pp. 410-417
-
-
Basile, V.S.1
-
15
-
-
0033608466
-
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
-
(1999)
Lancet
, vol.353
, pp. 717-719
-
-
Aithal, G.P.1
-
17
-
-
0029588524
-
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity
-
(1995)
Pharmacol. Ther.
, vol.68
, pp. 385-424
-
-
Park, B.K.1
-
22
-
-
0001697297
-
Extension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness
-
(2000)
J. Clin. Psychopharmacol.
, vol.20
, pp. 246-251
-
-
Chou, W.H.1
-
23
-
-
0031721749
-
Prevention of stroke in patients with nonvalvular atrial fibrillation
-
(1998)
Neurology
, vol.51
, pp. 674-681
-
-
Hart, R.G.1
-
24
-
-
0032910944
-
Frequency of major complications of aspirin, warfarin, and intravenous heparin for secondary stroke prevention - A population-based study
-
(1999)
Ann. Intern. Med.
, vol.130
, pp. 14-22
-
-
Petty, G.W.1
-
25
-
-
0026519541
-
Hydroxylation of warfarin by human cDNA-expressed cytochrome-P-450 - A role for P-4502C9 in the etiology of (s)-warfarin drug-interactions
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 54-59
-
-
Rettie, A.E.1
-
26
-
-
0029564238
-
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy
-
(1995)
Pharmacogenetics
, vol.5
, pp. 389-392
-
-
Furuya, H.1
-
27
-
-
0030587544
-
Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms
-
(1996)
Arch. Biochem. Biophys.
, vol.333
, pp. 447-458
-
-
Haining, R.L.1
-
28
-
-
7844247934
-
Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: Catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes
-
(1998)
Pharmacogenetics
, vol.8
, pp. 365-373
-
-
Takahashi, H.1
-
29
-
-
0034283762
-
Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
-
(2000)
Blood
, vol.96
, pp. 1816-1819
-
-
Taube, J.1
-
30
-
-
0033884635
-
Cytochrome P450 polymorphisms are associated with reduced warfarin dose
-
(2000)
Surgery
, vol.128
, pp. 281-285
-
-
Freeman, B.D.1
-
33
-
-
0032494736
-
Multicentre randomised study of computerised anticoagulant dosage
-
(1998)
Lancet
, vol.352
, pp. 1505-1509
-
-
Poller, L.1
-
34
-
-
0034622382
-
Oral anticoagulation self-management and management by a specialist anticoagulation clinic: A randomised cross-over comparison
-
(2000)
Lancet
, vol.356
, pp. 97-102
-
-
Cromheecke, M.E.1
-
37
-
-
0034034158
-
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
-
(2000)
Leukemia
, vol.14
, pp. 567-572
-
-
McLeod, H.L.1
-
39
-
-
0034671387
-
Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: A pharmacogenetic analysis
-
(2000)
Cancer Res.
, vol.60
, pp. 6921-6926
-
-
Ando, Y.1
-
40
-
-
0033656847
-
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity
-
(2000)
Pharmacogenetics
, vol.10
, pp. 705-713
-
-
Pirmohamed, M.1
-
41
-
-
0031787340
-
Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs
-
(1989)
Epilepsia
, vol.39
, Issue.SUPPL. 7
-
-
Leeder, J.S.1
-
42
-
-
0028902661
-
Glutathione S-transferase μ genotype (GSTM1*O) in Alzheimer's patients with tacrine transaminitis
-
(1995)
Br. J. Clin. Pharmacol.
, vol.39
, pp. 411-415
-
-
Green, V.J.1
-
43
-
-
0031826404
-
No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease
-
(1998)
Pharmacogenetics
, vol.8
, pp. 353-355
-
-
DeSousa, M.1
-
46
-
-
0030934850
-
Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
-
(1997)
Ann. Intern. Med.
, vol.126
, pp. 608-614
-
-
Yates, C.R.1
-
47
-
-
0025837127
-
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
-
(1991)
J. Pediatr.
, vol.119
, pp. 985-989
-
-
Evans, W.E.1
-
48
-
-
0027401302
-
Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
-
(1993)
Lancet
, vol.341
, pp. 436
-
-
Schutz, E.1
-
49
-
-
0025331198
-
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
-
(1990)
Lancet
, vol.336
, pp. 225-259
-
-
Lennard, L.1
-
50
-
-
0033486029
-
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 2001-2008
-
-
Relling, M.V.1
-
51
-
-
0033135738
-
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
-
(1999)
Blood
, vol.93
, pp. 2817-2823
-
-
Relling, M.V.1
-
52
-
-
0033519986
-
High incidence of secondary brain tumours after radiotherapy and antimetabolites
-
(1999)
Lancet
, vol.354
, pp. 34-39
-
-
Relling, M.V.1
-
53
-
-
0017880983
-
Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
-
(1978)
Clin. Chim. Acta
, vol.85
, pp. 323-333
-
-
Weinshilboum, R.M.1
-
55
-
-
0032519431
-
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 847-854
-
-
Iyer, L.1
-
56
-
-
0032934383
-
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
-
(1999)
Clin. Pharmacol. Ther.
, vol.65
, pp. 576-582
-
-
Iyer, L.1
-
57
-
-
0029892497
-
P-glycoprotein in the blood-brain-barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
-
58
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
-
61
-
-
0034701812
-
A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1273-1281
-
-
Shapira, M.1
-
62
-
-
0030860288
-
Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitization in moderately severe stable asthmatics
-
(1997)
Lancet
, vol.350
, pp. 995-999
-
-
Tan, S.1
-
64
-
-
0032982269
-
Association of the MscI polymorphism of the dopamine D3 receptor gene with tardive dyskinesia in schizophrenia
-
(1999)
Neuropsychopharmacology
, vol.21
, pp. 17-27
-
-
Basile, V.S.1
-
65
-
-
0034087446
-
Ryanodine receptor mutations in malignant hyperthermia and central core disease
-
(2000)
Hum. Mutat.
, vol.15
, pp. 410-417
-
-
McCarthy, T.V.1
-
67
-
-
0033635776
-
Potassium channels: Molecular defects, diseases, and therapeutic opportunities
-
(2000)
Pharmacol. Rev.
, vol.52
, pp. 557-594
-
-
Shieh, C.C.1
-
68
-
-
0033574273
-
MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia
-
(1999)
Cell
, vol.97
, pp. 175-187
-
-
Abbott, G.W.1
-
70
-
-
0034605712
-
Idiosyncratic drug reactions: The reactive metabolite syndromes
-
(2000)
Lancet
, vol.356
, pp. 1587-1591
-
-
Knowles, S.R.1
-
72
-
-
0344721480
-
Complete sequence and gene map of a human major histocompatibility complex
-
(1999)
Nature
, vol.401
, pp. 921-923
-
-
-
73
-
-
0027534914
-
An allelic polymorphism within the human tumor-necrosis-factor-α promoter region is strongly associated with HLA-A1, HLA-B8, and HLA-DR3 alleles
-
(1993)
J. Exp. Med.
, vol.177
, pp. 557-560
-
-
Wilson, A.G.1
-
75
-
-
0028222385
-
Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine
-
(1994)
Arch. Dermatol.
, vol.130
, pp. 598-604
-
-
Friedmann, P.S.1
-
76
-
-
0022377259
-
Genetic predisposition to phenytoin-induced birth defects
-
(1985)
Lancet
, vol.2
, pp. 746-749
-
-
Strickler, S.M.1
-
77
-
-
0032748789
-
Concordance of primary generalised epilepsy and carbamazepine hypersensitivity in monozygotic twins
-
(1999)
Postgrad. Med. J.
, vol.75
, pp. 680-681
-
-
Edwards, S.G.1
-
79
-
-
0025721852
-
Carbamazepine hypersensitivity: Assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine
-
(1991)
Br. J. Clin. Pharmacol.
, vol.32
, pp. 741-749
-
-
Pirmohamed, M.1
-
80
-
-
0028352066
-
Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions
-
(1994)
Pharmacogenetics
, vol.4
, pp. 142-153
-
-
Gaedigk, A.1
-
81
-
-
0028880593
-
Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 1353-1359
-
-
Green, V.J.1
-
82
-
-
0035836342
-
TNF-α promoter region gene polymorphisms in carbamazepine-hypersensitive patients
-
in press
-
Neurology
-
-
Pirmohamed, M.1
-
83
-
-
0007932349
-
Interpretation of results from genetic studies of multifactorial diseases
-
(1999)
Lancet
, vol.354
, Issue.SUPPL. 1
-
-
Todd, J.A.1
-
84
-
-
0034660560
-
Pharmacogenetics and the practice of medicine
-
(2000)
Nature
, vol.405
, pp. 857-865
-
-
Roses, A.D.1
-
85
-
-
0035865322
-
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
-
(2001)
Nature
, vol.409
, pp. 928-933
-
-
-
87
-
-
0033816985
-
Testing drug response in the presence of genetic information: Sampling issues for clinical trials
-
(2000)
Pharmacogenetics
, vol.10
, pp. 503-510
-
-
Cardon, L.R.1
|