Will the genomics revolution revolutionize psychiatry?

American Journal of Psychiatry

Volumn 160, Issue 4, 2003, Pages 625-635

  Merikangas, Kathleen Ries ^a   Risch, Neil ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GENOMICS; HUMAN; MENTAL DISEASE; PRIORITY JOURNAL; REVIEW; ARTICLE; FORECASTING; GENETICS; PSYCHIATRY;

FORECASTING; GENOMICS; HUMANS; MENTAL DISORDERS; PSYCHIATRY;

EID: 0038135191     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.4.625     Document Type: Review

References (131)

1. Kallmann FJ: Review of psychiatric progress 1953. Am J Psychiatry 1954; 110:489-492
2. Kallmann FJ, Jarvik LF: Individual differences in constitution and genetic background, in Aging and the Individual. Edited by Birren JE. Chicago, University of Chicago Press, 1959
3. Stenstedt A: A study in manic-depressive psychosis: clinical, social, and genetic investigations. Acta Psychiatr Neurol Scand 1952; 42:398-409
4. Slater E: The incidence of mental disorder. Annals of Eugenics 1935; 6:172
5. Böök JA: A genetic and neuropsychiatric investigation of a north-Swedish population with special regard to schizophrenia and mental deficiency. Acta Genet Stat Med 1953; 4:70-84
6. Reich T, Clayton PJ, Winokur G: Family history studies, V: the genetics of mania. Am J Psychiatry 1969; 125:1358-1369
7. Tsuang M, Dempsey G, Dvoredsky A, Strauss A: A family history study of schizoaffective disorder. Biol Psychiatry 1977; 12:331-338
8. Winokur G, Tsuang MT, Crowe RR: The Iowa 500: affective disorder in relatives of manic and depressed patients. Am J Psychiatry 1982; 139:209-212
9. Andreasen NC, Rice J, Endicott J, Coryell W, Grove WM, Reich T: Familial rates of affective disorder: a report from the National Institute of Mental Health Collaborative Study. Arch Gen Psychiatry 1987; 44:461-469; correction, 1988; 45:776
10. Gershon ES, Hamovit J, Guroff JJ: A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch Gen Psychiatry 1982; 39:1157-1167
11. Weissman MM, Kidd KK, Prusoff BA: Variability in rates of affective disorders in relatives of depressed and normal probands. Arch Gen Psychiatry 1982; 39:1397-1403
12. Kendler KS: Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 2001; 58:1005-1014
13. Kety SS, Rosenthal D, Wender PH, Schulsinger F: The types of prevalence of mental illness in the biological and adoptive families of adopted schizophrenics, in The Transmission of Schizophrenia. Edited by Rosenthal D, Kety SS. Oxford, UK, Pergamon Press, 1968
14. Rosenthal D: Some factors associated with concordance and discordance with respect to schizophrenia in monozygotic twins. J Nerv Ment Dis 1959; 129:1-10
15. Weissman MM, Gershon ES, Kidd KK, Prusoff BA, Leckman JF, Dibble E, Hamovit JH, Thompson WD, Pauls DL, Guroff JJ: Psychiatric disorder in relatives of probands with affective disorders: the Yale University-NIMH Collaborative Family Study. Arch Gen Psychiatry 1984; 41:13-21
16. Plomin R, Defries JC, McClearn GE, McGuffin F: Behavioral Genetics. London, WH Freeman and Company, 2000
17. Merikangas KR, Swendsen JD: Genetic epidemiology of psychiatric disorders. Epidemiol Rev 1996; 19:1-12
18. McGuffin P, Owen MJ, Gottesman II: Psychiatric Genetics and Genomics. Oxford, UK, Oxford University Press, 2002
19. Moldin SO: Summary of research - appendix to the report of the NIMH's Genetics Workgroup. Biol Psychiatry 1999; 45:573-602
20. McGuffin P, Asherson P, Owen M, Farmer A: The strength of the genetic effect: is there room for an environmental influence in the aetiology of schizophrenia? Br J Psychiatry 1994; 164:593-599
21. Craddock N, Jones I: Molecular genetics of bipolar disorder. Br J Psychiatry Suppl 2001; 41:5128-5133
22. Sullivan PF, Neale MC, Kendler KS: Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000; 157:1552-1562
23. Kendler KS, Neale MC, Kassler RC: Panic disorder in women: a population-based twin study. Psychol Med 1993; 23:397-406
24. van den Heuvel OA, van de Wetering BJ, Veltman DJ, Pauls DL: Genetic studies of panic disorder: a review. J Clin Psychiatry 2000; 61:756-766
25. Smoller JW, Finn C, White C: The genetics of anxiety disorders: an overview. Psychiatr Annals 2000; 30:745-753
26. Nestadt G, Samuels J, Riddle M, Bienvenu OJI, Liang K-Y, La-Buda M, Walkup J, Grados M, Hoehn-Saric R: A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 2000; 57:358-363
27. Sullivan PF, Kendler KS: Typology of common psychiatric syndromes: an empirical study. Br J Psychiatry 1998; 173:312-319
28. Kendler KS, Prescott CA: Cannabis use, abuse, and dependence in a population-based sample of female twins. Am J Psychiatry 1998; 155:1016-1022
29. Kendler K, Prescott C: Cocaine use, abuse and dependence in a population-based sample of female twins. Br J Psychiatry 1998; 173:345-350
30. Merikangas KR: Genetic epidemiology of substance-use disorders, in Textbook of Biological Psychiatry. Edited by D'haenen, Den Boer J, Willner P. New York, John Wiley & Sons, 2002, pp 537-546
31. Uhl GR, Liu QR, Naiman D: Substance abuse vulnerability loci: converging genome scanning data. Trends Genet 2002; 18:420-425
32. Rice F, Harold G, Thapar A: The genetic aetiology of childhood depression: a review. J Child Psychol Psychiatry 2002; 43:65-79
33. Szatmari P, Jones MB, Zwaigenbaum L, MacLean JE: Genetics of autism: overview and new directions. J Autism Dev Disord 1998; 28:351-368
34. Risen N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, Kalaydjieva L, McCague P, Dimiceli S, Pitts T, Nguyen L, Yang J, Harper C, Thorpe D, Vermeer S, Young H, Hebert J, Lin A, Ferguson J, Chiotti C, Wiese-Slater S, Rogers T, Salmon B, Nicholas P, Myers RM, et al: A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet 1999; 65:493-507
35. International Molecular Genetic Study of Autism Consortium: A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet 1998; 7:571-578
36. Thapar A, Holmes J, Poulton K, Harrington R: Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 1999; 174:105-111
37. Thapar A, Scourfield J: Childhood disorders, in Psychiatric Genetics and Genomics. Edited by McGuffin P, Owen MJ, Gottesman II. Oxford, UK, Oxford University Press, 2002, pp 147-180
38. Rutter M, Silberg J, O'Connor T, Simonoff E: Genetics and child psychiatry, II: empirical research findings. J Child Psychol Psychiatry 1999; 40:19-55
39. Merikangas KR, Chakravarti A, Moldin SO, Araj H, Blangero J, Burmeister M, Crabbe JCJ, DePaulo JRJ, Foulks E, Freimer NB, Koretz DS, Lichtenstein W, Mignot E, Reiss AL, Risen NJ, Takahashi J (Workgroup on Genetics for NIMH Strategic Plan for Mood Disorders): Future of genetics of mood disorders research. Biol Psychiatry 2002; 52:457-477
40. Tsuang MT, Faraone SV: The Genetics of Mood Disorders. Baltimore, Johns Hopkins University Press, 1990
41. Goodwin FK, Jamison KR: Manic-Depressive Illness. New York, Oxford University Press, 1990
42. Wender PH, Kety SS, Rosenthal D, Schulsinger F, Ortmann J, Lunde I: Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Arch Gen Psychiatry 1986; 43:923-929
43. Mendlewicz J, Rainer JD: Adoption study supporting genetic transmission in manic-depressive illness. Nature 1977; 268:326-329
44. Risch NJ: Searching for genetic determinants in the new millennium. Nature 2000; 405:847-856
45. Botstein D, White RL, Skolnick M, Davis RW: Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 1980; 32:314-331
46. Weber JL, May PE: Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 1989; 44:388-396
47. Risch N, Merikangas KR: The future of genetic studies of complex human diseases. Science 1996; 273:1516-1517
48. Collins FS, Guyer MS, Charkravarti A: Variations on a theme: cataloging human DNA sequence variation. Science 1997; 278:1580-1581
49. Botstein D, Risch N: Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet Suppl 2003; 33
50. Patil N: Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 2001; 294:1719-1723
51. Gabriel SB: The structure of haplotype blocks in the human genome. Science 2002; 296:2225-2228
52. Wacholder S, Rothman N, Caporaso N: Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 2000; 92:1151-1158
53. Wacholder S, Garcia-Closas M, Rothman N: Study of genes and environmental factors in complex diseases (letter). Lancet 2002; 359:1155
54. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K: A comprehensive review of genetic association studies. Genet Med 2002; 4:45-61
55. Altmuller J, Palmer LJ, Fischer G, Scherb H, Wjst M: Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet 2001; 69:936-950
56. McInnes LA, Freimer NB: Mapping genes for psychiatric disorders and behavioral traits. Curr Opin Genet Dev 1995; 5:376-381
57. DeLisi LE, Craddock NJ, Detera-Wadleigh S, Foroud T, Gejman P, Kennedy JL, Lendon C, Macciardi F, McKeon P, Mynett-Johnson L, Nurnberger JI Jr, Paterson A, Schwab S, Van Broeckhoven C, Wildenauer D, Crow TJ: Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the Vllth World Congress of Psychiatric Genetics, Monterey, California, October 14-18, 1999. Am J Med Genet 2000; 96:434-149
58. Risch N: Searching for genes in complex diseases: lessons from systemic lupus erythematosus. J Clin Invest 2000; 105:1503-1506
59. Glazier AM, Nadeau JH, Aitman TJ: Finding genes that underlie complex traits. Science 2002; 298:2345-2349
60. Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjogren B, et al: An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 1995; 11:321-324
61. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Zambuto CT, Schmitt K, Meyer J, Markel P, Lee H, Harkavy Friedman J, Kaufmann C, Cloninger CR, Tsuang MT: Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet 1998; 81:290-295
62. O'Donovan MC, Owen MJ: Candidate-gene association studies of schizophrenia. Am J Hum Genet 1999; 65:587-592
63. Riley BP, McGuffin P: Linkage and associated studies of schizophrenia. Am J Med Genet 2000; 97:23-44
64. Sklar P: Linkage analysis in psychiatric disorders: the emerging picture. Annu Rev Genomics Hum Genet 2002; 3:371-413
65. Smoller JW, Tsuang MT: Panic and phobic anxiety: defining phenotypes for genetic science. Am J Psychiatry 1998; 155:1152-1162
66. Prathikanti S, McMahon FJ: Genome scans for susceptibility genes in bipolar affective disorder. Ann Med 2001; 33:257-262
67. Bassett AS, Chow EW, Vieland VJ, Brzustowicz L: Is schizophrenia linked to chromosome 1q? (letter). Science 2002; 298:2277
68. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS: Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000; 288:678-682
69. Macgregor S, Visscher PM, Knott S, Porteous D, Muir W, Millar K, Blackwood D: Is schizophrenia linked to chromosome 1q? (letter). Science 2002; 298:2277
70. Levinson DF, Holmans PA, Laurent C, Riley B, Pulver AE, Gejman PV, Schwab SG, Williams NM, Owen MJ, Wildenauer DB, Sanders AR, Nestadt G, Mowry BJ, Wormley B, Bauche S, Soubigou S, Ribble R, Nertney DA, Liang KY, Martinolich L, Maier W, Norton N, Williams H, Albus M, Carpenter EB, DeMarchi N, Ewen-White KR, Walsh D, Jay M, Deleuze JF, O'Neill FA, Papadimitriou G, Weilbaecher A, Lerer B, O'Donovan MC, Dikeos D, Silverman JM, Kendler KS, Mallet J, Crowe RR, Walters M: No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 2002; 296:739-741
71. Risch N, Botstein DA: A manic depressive history. Nat Genet 1996; 12:351-353
72. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G: A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96:5604-5609
73. Kendell RE: Clinical validity. Psychol Med 1989; 19:45-55
74. Kessler RC, Üstün TB: The World Health Organization World Mental Health 2000 Initiative. Hosp Management Int 2000: 195-196
75. Dolan RJ: Emotion, cognition, and behavior. Science 2002; 298:1191-1194
76. McKhann GM: Neurology: then, now, and in the future. Arch Neurol 2002; 59:1369-1373
77. Gottesman I, Shields J: Schizophrenia and Genetics: A Twin Study Vantage Point. New York, Academic Press, 1972
78. Risch N: Linkage strategies for genetically complex traits, I: multilocus models. Am J Hum Genet 1990; 46:222-228
79. Guttmacher AE, Collins FS: Genomic medicine - a primer. N Engl J Med 2002; 347:1512-1520
80. Maier W, Merikangas KR: Co-occurrence and transmission of affective disorders and alcoholism in families. Br J Psychiatry Suppl 1996; 168:93-100
81. Merikangas KR, Angst J, Eaton W, Canino G, Rubio-Stipec M, Wacker H, Wittchen HU, Andrade L, Essau C, Whitaker A, Kraemer H, Robins LN, Kupfer DJ: Comorbidity and boundaries of affective disorders with anxiety disorders and substance misuse: results of an international task force. Br J Psychiatry Suppl 1996; 30:58-67
82. Merikangas KR, Stevens DE, Fenton B, Stolar M, O'Malley S, Woods SW, Risch N: Comorbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med 1998; 28:773-788
83. Maier W, Lichtermann D, Minges J, Delmo C, Heun R: The relationship between bipolar disorder and alcoholism: a controlled family study. Psychol Med 1995; 25:787-796
84. Merikangas KR: Assortative mating for psychiatric disorders and psychological traits. Arch Gen Psychiatry 1982; 39:1173-1180
85. Galbaud du Fort G, Bland RC, Newman SC, Boothroyd LJ: Spouse similarity for lifetime psychiatric history in the general population. Psychol Med 1998; 28:789-802
86. Merikangas KR, Gelernter CS: Comorbidity for alcoholism and depression. Psychiatr Clin North Am 1990; 13:613-632
87. Merikangas KR, Rounsaville BJ, Prusoff BA: Familial factors in vulnerability to substance abuse, in Vulnerability to Drug Abuse. Edited by Glantz MD, Pickens RW. Washington, DC, American Psychological Association, 1992, pp 75-98
88. Kupfer DJ, First MB, Regier DA: A Research Agenda for DSM-V. Washington, DC, APA, 2002
89. Angst J, Merikangas KR, Preisig M: Subthreshold syndromes of depression and anxiety in the community. J Clin Psychiatry 1997; 58(suppl 8):6-10
90. Judd LL, Akiskal HS, Maser JD, Zeller PJ, Endicott J, Coryell W, Paulus MP, Kunovac JL, Leon AC, Mueller TI, Rice JA, Keller MB: A prospective 12-year study of subsyndromal and syndromal depressive symptoms in unipolar major depressive disorders. Arch Gen Psychiatry 1998; 55:694-700
91. Angst J, Merikangas KR: The depressive spectrum: diagnostic classification and course. J Affect Disord 1997; 45:31-40
92. Lenox RH, Gould TD, Manji HK: Endophenotypes in bipolar disorder. Am J Med Genet 2002; 114:391-406
93. Tsuang MT, Faraone SV, Lyons MJ: Identification of the phenotype in psychiatric genetics. Eur Arch Psychiatry Clin Neurosci 1993; 243:131-142
94. Faraone SV, Kremen WS, Lyons MJ, Pepple JR, Seidman LJ, Tsuang MT: Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes? Am J Psychiatry 1995; 152:1286-1290
95. Lichtermann D, Karbe E, Maier W: The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders. Eur Arch Psychiatry Clin Neurosci 2000; 250:304-310
96. Castellanos FX, Tannock R: Neuroscience of attention-deficit/ hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002; 3:617-628
97. Thompson PM, Rapoport JL, Cannon TD, Toga AW: Imaging the brain as schizophrenia develops: dynamic and genetic brain maps. Primary Psychiatry, Nov 2002, pp 40-44
98. Merikangas KR: Genetic epidemiology: bringing genetics to the population - the NAPE Lecture 2001. Acta Psychiatr Scand 2002; 105:3-13
99. Gordis L: Epidemiology. Philadelphia, WB Saunders, 2000
100. Ellsworth DL, Manolio TA: The emerging importance of genetics in epidemiologic research, II: issues in study design and gene mapping. Ann Epidemiol 1999; 9:75-90
101. Ellsworth DL, Manolio TA: The emerging importance of genetics in epidemiologic research, III: bioinformatics and statistical genetic methods. Ann Epidemiol 1999; 9:207-224
102. Khoury MJ, Beaty TH, Cohen BH: Fundamentals of Genetic Epidemiology. New York, Oxford University Press, 1993
103. Ödegaard Ö: Emigration and Insanity: A Study of Mental Disorders Among the Norwegian Born Population of Minnesota. Copenhagen, Levin & Munksgaards, 1932
104. Langholz B, Rothman N, Wacholder S, Thomas DC: Cohort studies for characterizing measured genes. J Natl Cancer Inst Monogr 1999; 26:39-42
105. Khoury MJ, Yang Q: The future of genetic studies of complex human disease: an epidemiologic perspective. Epidemiology 1998; 9:350-354
106. Thomas DC: Genetic epidemiology with a capital "E." Genet Epidemiol 2000; 19:289-300
107. Yang Q, Khoury MJ, Coughlin SC, Sun F, Flanders WD: On the use of population-based registries in the clinical validation of genetic tests for disease susceptibility. Genet Med 2000; 2:186-192
108. Khoury MJ, McCabe LL, McCabe ER: Population screening in the age of genomic medicine. N Engl J Med 2003; 348:50-58
109. Slooter A, van Duijn C: Genetic epidemiology of Alzheimer disease. Epidemiol Rev 1997; 19:107-119
110. Tol J, Roks G, Slooter AJ, van Duijn CM: Genetic and environmental factors in Alzheimer's disease. Rev Neurol (Paris) 1999; 155(suppl 4):S10-S16
111. Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A: Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. Br Med J 2001; 322:1447-1451
112. Munoz DG, Feldman H: Causes of Alzheimer's disease. Can Med Assoc J 2000; 162:65-72
113. Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H: Apolipoprotein E epsilon 4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med 2002; 137:149-155
114. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM (APOE and Alzheimer Disease Meta Analysis Consortium): Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. JAMA 1997; 278:1349-1356
115. Newman B, Millikan RC, King M: Genetic epidemiology of breast and ovarian cancers. Epidemiol Rev 1997; 19:69-79
116. Ottman R: An epidemiologic approach to gene-environment interaction. Genet Epidemiol 1990; 7:177-185
117. Smith PG, Day NE: The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol 1984; 13:356-365
118. Hwang SJ, Beaty TH, Liang KY, Coresh J, Khoury MJ: Minimum sample size estimation to detect gene-environment interaction in case-control designs. Am J Epidemiol 1994; 140:1029-1037
119. Khoury MJ: Genetic epidemiology, in Modern Epidemiology, 2nd ed. Edited by Rothman K, Greenland S. Philadelphia, Lippincott-Raven, 1997
120. Yang Q, Khoury MJ: Evolving methods in genetic epidemiology, III: gene-environment interaction in epidemiologic research. Epidemiol Rev 1997; 19:33-43
121. Foppa I, Spiegelman D: Power and sample size calculations for case-control studies of gene-environment interactions with a polytomous exposure variable. Am J Epidemiol 1997; 146:596-604
122. Garcia-Closas M, Lubin JH: Power and sample size calculations in case-control studies of gene-environment interactions: comments on different approaches. Am J Epidemiol 1999; 149:689-692
123. Nebert DW, Ingelman-Sundberg M, Daly AK: Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metab Rev 1999; 31:467-487
124. Heath AC, Whitfield JB, Madden PA, Bucholz KK, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DB, Martin NG: Towards a molecular epidemiology of alcohol dependence: analysing the interplay of genetic and environmental risk factors. Br J Psychiatry Suppl 2001; 40:S33-S40
125. Dick DM, Rose RJ, Viken RJ, Kaprio J, Koskenvuo M: Exploring gene-environment interactions: socioregional moderation of alcohol use. J Abnorm Psychol 2001; 110:625-632
126. Michael NL: Host genetic influences on HIV-1 pathogenesis. Curr Opin Immunol 1999; 11:466-474
127. Eaton WW, Addington AM, Bass J, Forman V, Gilbert S, Hayden K, Mielke M: Risk factors for major mental disorders: a review of the epidemiologic literature. Baltimore, Johns Hopkins University, Bloomberg School of Mental Health, Department of Mental Hygiene, Oct 2002. http://www.jhu.edu/-janthony/ share/Envirome/Envirome-III-b.pdf
128. Gottesman II, Erlenmeyer-Kimling L: Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia. Schizophr Res 2001; 51:93-102
129. Meaney MJ: Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 2001; 24:1161-1192
130. Varmus H: Getting ready for gene-based medicine. N Engl J Med 2002; 347:1526-1527
131. Hyman SE: The genetics of mental illness: implications for practice. Bull World Health Organ 2000; 78:455-463