Enzyme/abzyme prodrug activation systems: Potential use in clinical oncology

Current Pharmaceutical Design

Volumn 9, Issue 26, 2003, Pages 2113-2130

  Nishi, Yoshisuke ^a,b  

^a JAPAN TOBACCO INC   (Japan)

^b Business Office   (Japan)

Author keywords

Antibody directed abzyme prodrug therapy (ADAPT); Antibody directed enzyme prodrug activation (ADEPT); Gene directed enzyme prodrug therapy (GDEPT); Polymer directed enzyme prodrug therapy (PDEPT); Virus directed enzyme prodrug therapy (VDEPT)

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ALKALINE PHOSPHATASE; ANILINE MUSTARD; ANILINE MUSTARD DERIVATIVE; ANTIBODY; BETA GLUCURONIDASE; BETA LACTAMASE; BISPECIFIC ANTIBODY; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE G2; CATALYTIC ANTIBODY; CYTOSINE DEAMINASE; DACTINOMYCIN; DAUNORUBICIN; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; FLOXURIDINE; FLUCYTOSINE; GLUCURONIDE; METHOTREXATE; MITOMYCIN C; N [4 [(2 CHLOROETHYL)(2 MESYLOXYETHYL)AMINO]BENZOYL]GLUTAMIC ACID; NITROREDUCTASE; PENICILLIN AMIDASE; POLYMER; PRODRUG; TALLIMUSTINE; THYMIDINE KINASE; UNINDEXED DRUG; VIRUS VECTOR;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; CANCER THERAPY; CATALYSIS; CELL KILLING; CYTOTOXICITY; DRUG ACTIVATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG TARGETING; EFFECTOR CELL; ENZYME ACTIVITY; GENETIC ENGINEERING; IMMUNOGENICITY; MEDICAL TECHNOLOGY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; TUMOR CELL; VIRAL GENE DELIVERY SYSTEM;

ANTIBODIES, CATALYTIC; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; ENZYMES; GENE THERAPY; HUMANS; NEOPLASMS; PRODRUGS;

EID: 0141538137     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612033454063     Document Type: Review

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