PDEPT: Polymer-directed enzyme prodrug therapy: I. HPMA copolymer-cathepsin B and PK1 as a model combination

British Journal of Cancer

Volumn 85, Issue 7, 2001, Pages 1070-1076

  Satchi, R ^a   Connors, T A ^a   Duncan, R ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

HPMA copolymer; PDEPT; Polymer prodrugs; Polymer enzyme conjugate; Tumour targeting

Indexed keywords

CATHEPSIN B; COPOLYMER; DOXORUBICIN DERIVATIVE; ENZYME; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; POLYMER; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR;

ANIMALS; AREA UNDER CURVE; CATHEPSIN B; COMBINED MODALITY THERAPY; ENZYME ACTIVATION; HALF-LIFE; INFUSIONS, INTRAVENOUS; MALE; MELANOMA; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; POLYMETHACRYLIC ACIDS; PRODRUGS; SKIN NEOPLASMS;

EID: 0035964623     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6692026     Document Type: Article

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