Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate

Journal of Biological Chemistry

Volumn 272, Issue 25, 1997, Pages 15804-15816

  Smith, Gary K ^a   Banks, Sheila ^a   Blumenkopf, Todd A ^a,b   Cory, Michael ^a   Humphreys, Joan ^a   Laethem, Ronald M ^a   Miller, John ^a   Moxham, Cary P ^a   Mullin, Robert ^a   Ray, Paul H ^a   Walton, Leslie M ^a   Wolfe III, Lawrence A ^a  

^a GLAXOSMITHKLINE   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; CARBOXYPEPTIDASE A; ENZYME ANTIBODY; METHOTREXATE; PRODRUG;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ARTICLE; CANCER THERAPY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; CYTOTOXICITY; ENZYME BINDING; ENZYME KINETICS; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS;

ANIMALS; ANTIBODIES; ANTIMETABOLITES, ANTINEOPLASTIC; BINDING SITES; CARBOXYPEPTIDASES; CARBOXYPEPTIDASES A; CATTLE; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG STABILITY; HT29 CELLS; HUMANS; HYDROLYSIS; ISOENZYMES; KINETICS; MACROMOLECULAR SUBSTANCES; METHOTREXATE; MODELS, MOLECULAR; MUTAGENESIS; PANCREAS; PANCREATIC JUICE; PHENYLALANINE; PRODRUGS;

EID: 0030965992     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.25.15804     Document Type: Article

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