Toward antibody-directed "abzyme" prodrug therapy, ADAPT: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 2, 1996, Pages 799-803

  Wentworth, Paul ^a,c   Datta, Anita ^a   Blakey, David ^b   Boyle, Tom ^b   Partridge, Lynda J ^a   Blackburn, G Michael ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; CARBAMIC ACID; PRODRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; DRUG ACTIVATION; HUMAN; HUMAN CELL; IMMUNOGENICITY; PRIORITY JOURNAL; TARGET ORGAN;

ANILINE MUSTARD; ANTIBODIES, CATALYTIC; ANTIBODY AFFINITY; ANTINEOPLASTIC AGENTS, ALKYLATING; CARCINOMA; COLONIC NEOPLASMS; HAPTENS; HUMANS; HYDROLYSIS; NITROGEN MUSTARD COMPOUNDS; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 0029671436     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.2.799     Document Type: Article

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