New mustard prodrugs for antibody-directed enzyme prodrug therapy: Alternatives to the amide link

Journal of Medicinal Chemistry

Volumn 39, Issue 5, 1996, Pages 1100-1105

  Dowell, Robert I ^a   Springer, Caroline J ^b   Davies, David H ^a   Hadley, Elizabeth M ^a   Burke, Philip J ^c   Boyle, F Thomas ^a   Melton, Roger G ^d   Connors, Thomas A ^b   Blakey, David C ^a   Mauger, Anthony B ^b  

^a ASTRAZENECA   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; BENZOIC ACID DERIVATIVE; MUSTARD GAS DERIVATIVE; N [ 4 [N,N BIS(2 CHLOROETHYL)AMINO]PHENYL]CARBAMOYL]GLUTAMIC ACID; N [[4 [N,N BIS(2 CHLOROETHYL)AMINO]PHENOXY]CARBONYL]GLUTAMIC ACID; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; COLORECTAL CANCER; CYTOTOXICITY; DRUG SYNTHESIS; MOUSE; NONHUMAN;

ANILINE MUSTARD; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL DIVISION; COLORECTAL NEOPLASMS; GAMMA-GLUTAMYL HYDROLASE; HUMANS; IMMUNOTOXINS; MOLECULAR STRUCTURE; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 13344276593     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950671l     Document Type: Article

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