Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells

European Journal of Immunology

Volumn 32, Issue 11, 2002, Pages 3102-3107

  Bortoletto, Nicola ^a   Scotet, Emmanuel ^c   Yoichi, Myamoto ^c   D'Oro, Ugo ^a   Lanzavecchia, Antonio ^b  

^a CHIRON VACCINES   (Italy)

^b Institute for Research in Biomed   (Switzerland)

^c BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

Bispecific antibody; T cell activation; T cell targeting; T lymphocyte; Tumor immunotheraphy

Indexed keywords

BISPECIFIC ANTIBODY; CD3 ANTIGEN; CELL ADHESION MOLECULE; T LYMPHOCYTE RECEPTOR;

ANTIBODY AFFINITY; ANTIGEN BINDING; CELL MEDIATED CYTOTOXICITY; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR CELL;

ANTIBODIES, BISPECIFIC; ANTIBODY AFFINITY; ANTIGENS, CD3; CELL LINE; HUMANS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; NEOPLASMS; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0036856493     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200211)32:11<3102::AID-IMMU3102>3.0.CO;2-C     Document Type: Review

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