In vitro abzyme evolution to optimize antibody recognition for catalysis

Nature Biotechnology

Volumn 19, Issue 6, 2001, Pages 563-567

  Takahashi, Naoko ^a   Kakinuma, Hiroyuki ^a   Liu, Lidong ^b   Nishi, Yoshisuke ^a   Fujii, Ikuo ^b  

^a JAPAN TOBACCO INC   (Japan)

^b BIOMOL ENG RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BINDING ENERGY; CATALYSIS; GROUND STATE; MUTAGENESIS; STRUCTURAL ANALYSIS;

ABZYMES; ANTIBODY RECOGNITION;

ENZYMES;

CATALYTIC ANTIBODY;

ARTICLE; BINDING AFFINITY; CATALYSIS; CODON; DNA LIBRARY; GENE MUTATION; IMMUNE RESPONSE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN VARIANT; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIBODIES, CATALYTIC; ANTIBODY AFFINITY; BASE SEQUENCE; CATALYTIC DOMAIN; CLONING, MOLECULAR; CODON; DIRECTED MOLECULAR EVOLUTION; GENE LIBRARY; HYDROLYSIS; IMMUNOGLOBULIN FRAGMENTS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY;

EID: 0035011047     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/89320     Document Type: Article

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