Stimulation of tolbutamide hydroxylation by acetone and acetonitrile in human liver microsomes and in a cytochrome P-450 2C9-reconstituted system

Drug Metabolism and Disposition

Volumn 28, Issue 1, 2000, Pages 38-43

  Palamanda, Jairam ^a   Feng, Wei Wei ^a   Lin, Chin Chung ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ACETONITRILE; ALDEHYDE; CUMENE HYDROPEROXIDE; CYTOCHROME P450 2C9; KETONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TOLBUTAMIDE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG INHIBITION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER MICROSOME; PRIORITY JOURNAL;

ACETONE; ACETONITRILES; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; HYDROXYLATION; HYPOGLYCEMIC AGENTS; MALE; MICROSOMES, LIVER; NADP; SOLVENTS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; TOLBUTAMIDE;

EID: 0033960957     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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