Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N- dialkylanilines by cytochrome P450 2B1: Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates

Journal of Biological Chemistry

Volumn 271, Issue 44, 1996, Pages 27321-27329

  Guengerich, F Peter ^a   Yun, Chul Ho ^a,c   Macdonald, Timothy L ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c PaiChai University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC AMINE; AMINOPHENAZONE; ANILINE DERIVATIVE; ANISOLE DERIVATIVE; BENZENE DERIVATIVE; CYTOCHROME P450; DEUTERIUM; HORSERADISH PEROXIDASE; HYDROGEN; N,N DIALKYLANILINE; OXYGEN; PEROXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; DEALKYLATION; DEMETHYLATION; ELECTRON; ELECTRON TRANSPORT; ENERGY; OXIDATION; PRIORITY JOURNAL;

ALKYLATION; ANILINE COMPOUNDS; ANIMALS; CYTOCHROME P-450 CYP2B1; ELECTRONS; HORSERADISH PEROXIDASE; KINETICS; MICROSOMES, LIVER; MODELS, CHEMICAL; OXIDATION-REDUCTION; PHENOBARBITAL; RATS; SUBSTRATE SPECIFICITY;

ARMORACIA RUSTICANA;

EID: 0029970784     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.44.27321     Document Type: Article

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