Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes

Archives of Biochemistry and Biophysics

Volumn 325, Issue 2, 1996, Pages 174-182

  Yamazaki, Hiroshi ^a   Nakano, Masami ^a   Imai, Yoshio ^b   Ueng, Yune Fang ^c   Guengerich, F Peter ^c   Shimada, Tsutomu ^a  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^b Osaka Prefecture University   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cytochrome b5; electron transfer; MgCl2; nifedipine; P450 3A4; reconstitution; testosterone

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450; NIFEDIPINE; TESTOSTERONE; CYP3A PROTEIN, HUMAN; MAGNESIUM CHLORIDE; MIXED FUNCTION OXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT PROTEIN;

ARTICLE; DRUG OXIDATION; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER MICROSOME METABOLISM; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; STEROID HYDROXYLATION; ANIMAL; DRUG EFFECT; IN VITRO STUDY; KINETICS; LIVER MICROSOME; METABOLISM; RABBIT;

BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS; ANIMALIA;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; HUMANS; KINETICS; MAGNESIUM CHLORIDE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NAD; NADP; NIFEDIPINE; OXIDATION-REDUCTION; RABBITS; RECOMBINANT PROTEINS; TESTOSTERONE;

EID: 0029671251     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1996.0022     Document Type: Article

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