Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

Journal of Biological Chemistry

Volumn 275, Issue 24, 2000, Pages 17974-17978

  Chen, Zhi ^a   Sun, Jiazhi ^a   Pradines, Anne ^b   Favre, Gilles ^b   Adnane, Jalila ^a   Sebti, Saïd M ^a,c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESYL TRANS TRANSFERASE; GUANOSINE TRIPHOSPHATASE; SOMATOMEDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; ENZYME ACTIVITY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; PROTEIN ISOPRENYLATION; RHOA GTP-BINDING PROTEIN; RHOB GTP-BINDING PROTEIN; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 0034674417     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C000145200     Document Type: Article

References (19)

1. McCormick, F. (1993) Nature 363, 15-16
2. Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J., and Der, C. J. (1998) Oncogene 17, 1395-1413
3. Zohn, I. M., Campbell, S. L., Khosravi-Far, R., Rossman, K. L., and Der, C. J. (1998) Oncogene 17, 1415-1438
4. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827
5. Bos, J. L. (1989) Cancer Res. 49, 4682-4689
6. Olson, M. F., Ashworth, A., and Hall, A. (1995) Science 269, 1270-1272
7. Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S., and Der, C. J. (1995) Mol. Cell. Biol. 15, 6443-6453
8. Qiu, R. G., Chen, J., Kirn, D., McCormick, F., and Symons, M. (1995) Nature 374, 457-459
9. Mellor, H., Flynn, P., Nobes, C. D., Hall, A., and Parker, P. J. (1998) J. Biol. Chem. 273, 4811-4814
10. Jahner, D., and Hunter, T. (1991) Mol. Cell. Biol. 11, 3682-3690
11. Fritz, G., Kaina, B., and Aktories, K. (1995) J. Biol. Chem. 270, 25172-25177
12. Zhang, F. L., and Casey, P. J. (1996) Annu. Rev. Biochem. 65, 241-269
13. Lebowitz, P. F., Casey, P. J., Prendergast, G. C., and Thissen, J. A. (1997) J. Biol. Chem. 272, 15591-15594
14. Sebti, S. M., and Hamilton, A. D. (1997) Pharmacol. Ther. 74, 103-114
15. Gibbs, J. B., and Oliff, A. (1997) Annu. Rev. Pharmacol. Toxicol. 37, 143-166
16. Cox, A. D., and Der, C. J. (1997) Biochim. Biophys. Acta 1333, F51-F71
17. Lebowitz, P. F., and Prendergast, G. C. (1998) Oncogene 17, 1439-1445
18. Sun, J., Blaskovich, M. A., Knowles, D., Qian, Y., Ohkanda, J., Bailey, R. D., Hamilton, A. D., and Sebti, S. M. (1999) Cancer Res. 59, 4919-4926
19. Prendergast, G. C., Khosravi-Far, R., Solski, P. A., Kurzawa, H., Lebowitz, P. F., and Der, C. J. (1995) Oncogene 10, 2289-2296