Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt

Cancer Research

Volumn 59, Issue 12, 1999, Pages 2815-2819

  Majewski, Miroslaw ^a   Nieborowska Skorska, Malgorzata ^a   Salomoni, Paolo ^a   Slupianek, Artur ^a   Reiss, Krzysztof ^a   Trotta, Rossana ^a   Calabretta, Bruno ^a,b   Skorski, Tomasz ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN SERINE THREONINE KINASE; RAF PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER RESEARCH; CELL SURVIVAL; CELL TRANSFORMATION; CELL VIABILITY; ENZYME ACTIVATION; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; APOPTOSIS; CELL LINE; ENZYME ACTIVATION; MICE; MITOCHONDRIA; ONCOGENE PROTEIN V-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RETROVIRIDAE PROTEINS, ONCOGENIC;

EID: 0033564140     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K. Kaplan, D. R., and Tsichlis, P. N. The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 81: 727-736, 1995.
2. Hungering, B. M., and Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3OH kinase signal transduction. Nature (Lond.), 376: 599-602, 1995.
3. Kennedy, S., Wagner, A. J., Canzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N., and Hay, N., The PI 3-kinase/Akt signalling pathway delivers an anti-apoptotic signal. Genes Dev., 11: 701-713, 1997.
4. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D., and Franke, T. F., Interleukin 3-dependent survival by the Akt protein kinase. Proc. Natl. Acad. Sci. USA, 96: 11345-11350, 1997.
5. Franke, T. F., Kaplan, D. R., and Cantley, L. C. PI3K: downstream AKTion blocks apoptosis. Cell, 88: 435-437, 1997.
6. Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O., and Tsichlis, P. N. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA, 96: 3627-3632, 1997.
7. Skorski, T., Bellacosa, A., Nieborowska-Skorska, M., Martinez, R., Majewski, M., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chen, T., Wasik, M., Tsichlis, P. N., and Calabretta, B. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J., 16: 6151-6161, 1997.
8. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91: 231-241, 1997.
9. del Peso, L., Gonzales-Garcia, M., Page, C., Herrera, R., and Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science (Washington DC), 278: 687-689, 1997.
10. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbrdige E., Frish, S., and Reed, J. C. Regulation of cell death protease caspase-9 by phosphorylation. Science (Washington DC), 282: 1318-1321, 1998.
11. Zha, J., Harado, H., Yang, E., Jockel, J., and Korsmeyer, S. J. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3-not BCL-X. Cell, 87: 619-628, 1996.
12. Wang, H. G., Rapp, U. R., and Reed, J. C. Bcl-2 targets the protein Raf-1 to mitochondria. Cell, 87: 629-638, 1996.
13. Salomoni, P., Wasik, M. A., Riedel, R. F., Reiss, K., Choi, J. K., Skorski, T., and Calabretta, B. Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J. Exp. Med., 187: 1995-2007, 1998.
14. Feig, L. A., and Cooper, G. M. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol., 8: 3235-3243, 1988.
15. Greenberger, J. S., Sakaheeny, M. A., Humpries, R. K., Eaves, C. J., and Eckner, R. J. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/ basophil) hematopoietic progenitor cell lines. Proc. Natl. Acad. Sci. USA, 80: 2931-2935, 1983.
16. Skorski, T., Nieborowska-Skorska M., Szczylik, C., Kanakaraj, P., Zon, G., Gevirtz, A. M., Perussia, B., and Calabretta, B. c-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis. Cancer Res., 55: 2275-2278, 1995.
17. Skorski, T., Kanakaraj, P., Nieborowska-Skorska, M., Ku, D. H., Canaani, E., Penessia, B., and Calabretta, B. Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth. J. Exp. Med., 179: 1855-1865, 1994.
18. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., and Saltiel, A. R. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA, 92: 7686-7689, 1995.
19. Wang, H-G., Takayama, S., Rapp, U. R., and Reed, J. C. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. USA, 93: 7063-7068, 1996.
20. Sozeri, O., Vollmer, K. Liyanage, M., Frith, D., Kour, G., Mark, G. E., III, and Stabel, S. Protein kinase by protein kinase C phosphorylation. Oncogene, 7: 2259-2262, 1992.
21. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D., and Rapp, U. R. Protein kinase C a activates RAF-1 by direct phosphorylation. Nature (Lond.), 364: 249-252, 1993.
22. Cacace, A. M., Ueffling, M., Philipp, A., Han, E. K., Kolch, W., and Weinstein, I. B. PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase. Oncogene, 13: 2517-2526, 1996.
23. Schonwasser, D. C., Marais, R. M., Marshall, C. J., and Parker, P. J. Activation of the nitrogen-activated protein kinase/extra-cellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol., 18: 790-798, 1998.
24. Ueda, Y., Hirai, S. I., Osada, S. I., Suzuki, A., Mizuno, K., and Ohno, S. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem., 271: 23512-23519, 1996.
25. Downward, J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol., 10: 262-267, 1998.
26. Marais, R., Light, Y., Mason, C., Paterson, H., Olson, M. F., and Marshall, C. J. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science (Washington DC), 280: 109-112, 1998.
27. Gajewski, T. F., and Thompson, C. B. Apoptosis meets signal transduction. Elimination of a BAD influence. Cell, 87: 589-592, 1996.
28. Ward, N. E., and O'Brian, C. A. Inhibition of protein kinase C by N-myristoylated peptide substrate analogs. Biochemistry, 32: 11903-11909, 1993.