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Volumn 6, Issue 1, 2003, Pages 29-39

The role of somatic and germline mutations in aging and a mutation interaction model of aging

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CHROMOSOME SEGREGATION; DNA REPAIR; DNA REPLICATION; GERM LINE; HETEROZYGOSITY; LIFESPAN; MOSAICISM; MUTATION; MUTATION RATE; PRIORITY JOURNAL; REPRODUCTION; SENESCENCE; SOMATIC MUTATION;

EID: 0038779300     PISSN: 10945458     EISSN: None     Source Type: Journal    
DOI: 10.1089/109454503765361560     Document Type: Article
Times cited : (8)

References (148)
  • 1
    • 0027469970 scopus 로고
    • Optimality, mutation and the evolution of aging
    • Partridge L, Barton NH. Optimality, mutation and the evolution of aging. Nature 1993;362:305-311.
    • (1993) Nature , vol.362 , pp. 305-311
    • Partridge, L.1    Barton, N.H.2
  • 2
    • 0027764702 scopus 로고
    • Evolutionary mechanisms of senescence
    • Charlesworth B. Evolutionary mechanisms of senescence. Genetica 1993;91:11-13.
    • (1993) Genetica , vol.91 , pp. 11-13
    • Charlesworth, B.1
  • 5
    • 7344254682 scopus 로고    scopus 로고
    • Mutation and senescence: Where genetics and demography meet
    • Promislow DEL, Tatar M. Mutation and senescence: where genetics and demography meet. Genetica 1998; 102/103:299-313.
    • (1998) Genetica , vol.102-103 , pp. 299-313
    • Promislow, D.E.L.1    Tatar, M.2
  • 6
    • 0033152519 scopus 로고    scopus 로고
    • The evolutionary genetics of ageing and longevity
    • Zwaan BJ. The evolutionary genetics of ageing and longevity. Heredity 1999;82:589-597.
    • (1999) Heredity , vol.82 , pp. 589-597
    • Zwaan, B.J.1
  • 7
    • 0012278503 scopus 로고    scopus 로고
    • Evolutionary theories of aging and longevity
    • Gavrilov LA, Gavrilova NS. Evolutionary theories of aging and longevity. Scientific World J 2002;2:339-356.
    • (2002) Scientific World J , vol.2 , pp. 339-356
    • Gavrilov, L.A.1    Gavrilova, N.S.2
  • 8
    • 0030967939 scopus 로고    scopus 로고
    • Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
    • Nuzhdin SV, Pasyukova EG, Dilda CL, et al. Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Proc Natl Acad Sci USA 1997; 94:9734-9739.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9734-9739
    • Nuzhdin, S.V.1    Pasyukova, E.G.2    Dilda, C.L.3
  • 9
    • 0036245337 scopus 로고    scopus 로고
    • Mechanisms of ageing: Public or private?
    • Partridge L, Gems D. Mechanisms of ageing: public or private? Nat Rev Genet 2002;3:165-175.
    • (2002) Nat Rev Genet , vol.3 , pp. 165-175
    • Partridge, L.1    Gems, D.2
  • 10
    • 85013514384 scopus 로고
    • The role of mutation in evolution
    • Bittar EE, Bittar N, eds. Greenwich, CT: JAI Press Inc
    • Crow JF. The role of mutation in evolution. In: Bittar EE, Bittar N, eds. Principles of Medical Biology, Volume 1B, Evolutionary Biology. Greenwich, CT: JAI Press Inc., 1994:153-182.
    • (1994) Principles of Medical Biology, Volume 1B, Evolutionary Biology , vol.1 B , pp. 153-182
    • Crow, J.F.1
  • 11
    • 31644443226 scopus 로고
    • Mutation, eugenics, genetics and the family
    • Muller HJ. Mutation, eugenics, genetics and the family. Proc Second Int Congress Eugenics 1923;1:106-112.
    • (1923) Proc Second Int Congress Eugenics , vol.1 , pp. 106-112
    • Muller, H.J.1
  • 12
  • 13
    • 0037016444 scopus 로고    scopus 로고
    • Combined functional genomic maps of the C. elegansr DNA damage response
    • Boulton SJ, Gartner A, Reboul J, et al. Combined functional genomic maps of the C. elegansr DNA damage response. Science 2002;295:127-131.
    • (2002) Science , vol.295 , pp. 127-131
    • Boulton, S.J.1    Gartner, A.2    Reboul, J.3
  • 14
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature 2001; 409:860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 15
    • 0035834921 scopus 로고    scopus 로고
    • The cytochrome P450 gene superfamily in Drosophila melanogaster: Annotation, intron-exon organization and phylogeny
    • Tijet N, Helvig C, Feyereisen R. The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogeny. Gene 2001;262:189-198.
    • (2001) Gene , vol.262 , pp. 189-198
    • Tijet, N.1    Helvig, C.2    Feyereisen, R.3
  • 16
    • 0035733710 scopus 로고    scopus 로고
    • Genes required for ionizing radiation resistance in yeast
    • Bennett CB, Lewis LK, Karthikeyan G et al. Genes required for ionizing radiation resistance in yeast. Nat Genet 2001;29:426-434.
    • (2001) Nat Genet , vol.29 , pp. 426-434
    • Bennett, C.B.1    Lewis, L.K.2    Karthikeyan, G.3
  • 20
    • 0026314114 scopus 로고
    • Evolution of senescence: Late survival sacrificed for reproduction
    • Kirkwood TB, Rose MR. Evolution of senescence: late survival sacrificed for reproduction. Philos Trans R Soc Lond B 1991;332:15-24.
    • (1991) Philos Trans R Soc Lond B , vol.332 , pp. 15-24
    • Kirkwood, T.B.1    Rose, M.R.2
  • 21
    • 0004114076 scopus 로고
    • Cambridge: Cambridge University Press
    • Holliday R. Understanding Ageing. Cambridge: Cambridge University Press, 1995.
    • (1995) Understanding Ageing
    • Holliday, R.1
  • 22
    • 0030070430 scopus 로고    scopus 로고
    • Somatic mutagenesis and antimutagenesis in aging research
    • Martin GM. Somatic mutagenesis and antimutagenesis in aging research. Mut Res 1996;350:35-41.
    • (1996) Mut Res , vol.350 , pp. 35-41
    • Martin, G.M.1
  • 23
    • 0029920370 scopus 로고    scopus 로고
    • Genetic analysis of ageing: Role of oxidative damage and environmental stresses
    • Martin GM, Austad SN, Johnson TE. Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet 1996;13:25-34.
    • (1996) Nat Genet , vol.13 , pp. 25-34
    • Martin, G.M.1    Austad, S.N.2    Johnson, T.E.3
  • 24
    • 0004261451 scopus 로고    scopus 로고
    • Sunderland, MA: Sinauer Associates, Inc
    • Arking R. Biology of Aging. Sunderland, MA: Sinauer Associates, Inc., 1998.
    • (1998) Biology of Aging
    • Arking, R.1
  • 25
    • 7344230525 scopus 로고    scopus 로고
    • Some evolutionary consequences of deleterious mutations
    • Woodruff RC, Thompson JN Jr., eds. Dordrecht, The Netherlands: Kluwer Academic Publishing
    • Charlesworth B, Charlesworth D. Some evolutionary consequences of deleterious mutations. In: Woodruff RC, Thompson JN Jr., eds. Mutation and Evolution. Dordrecht, The Netherlands: Kluwer Academic Publishing, 1998:3-19.
    • (1998) Mutation and Evolution , pp. 3-19
    • Charlesworth, B.1    Charlesworth, D.2
  • 26
    • 0033231963 scopus 로고    scopus 로고
    • Messages from mortality: The evolution of death rates in the old
    • Partridge L, Mangel M. Messages from mortality: the evolution of death rates in the old. Trends Ecol Evol 1999;14:438-442.
    • (1999) Trends Ecol Evol , vol.14 , pp. 438-442
    • Partridge, L.1    Mangel, M.2
  • 28
    • 0033953142 scopus 로고    scopus 로고
    • Somatic mutations and aging: A re-evaluation
    • Vijg J. Somatic mutations and aging: a re-evaluation. Mut Res 2000;447:117-135.
    • (2000) Mut Res , vol.447 , pp. 117-135
    • Vijg, J.1
  • 29
    • 0034992999 scopus 로고    scopus 로고
    • Stress, DNA damage and ageing-an integrative approach
    • von Zglinicki T, Burkle A, Kirkwood TBL. Stress, DNA damage and ageing-an integrative approach. Exp Gerontol 2001;36:1049-1062.
    • (2001) Exp Gerontol , vol.36 , pp. 1049-1062
    • Von Zglinicki, T.1    Burkle, A.2    Kirkwood, T.B.L.3
  • 30
    • 0033611501 scopus 로고    scopus 로고
    • High genomic deleterious mutation rates in hominids
    • Eyre-Walker A, Keightley PD. High genomic deleterious mutation rates in hominids. Nature 1999;397:344-347.
    • (1999) Nature , vol.397 , pp. 344-347
    • Eyre-Walker, A.1    Keightley, P.D.2
  • 31
    • 0032815107 scopus 로고    scopus 로고
    • Perspective: Spontaneous deleterious mutation
    • Lynch M, Blanchard J, Houle D, et al. Perspective: spontaneous deleterious mutation. Evolution 1999; 53:645-663.
    • (1999) Evolution , vol.53 , pp. 645-663
    • Lynch, M.1    Blanchard, J.2    Houle, D.3
  • 32
    • 0033828761 scopus 로고    scopus 로고
    • Estimate of the mutation rate per nucleotide in humans
    • Nachman MW, Crowell SL. Estimate of the mutation rate per nucleotide in humans. Genetics 2000;156:297-304.
    • (2000) Genetics , vol.156 , pp. 297-304
    • Nachman, M.W.1    Crowell, S.L.2
  • 34
    • 0030874916 scopus 로고    scopus 로고
    • Role of transposable elements in age-related genomic instability
    • Nikitin AG, Shmookler Reis RJ. Role of transposable elements in age-related genomic instability. Genet Res 1997;69:183-195.
    • (1997) Genet Res , vol.69 , pp. 183-195
    • Nikitin, A.G.1    Shmookler Reis, R.J.2
  • 35
    • 0032102720 scopus 로고    scopus 로고
    • Mobile elements and disease
    • Kazazian HH. Mobile elements and disease. Curr Opin Genet Dev 1998;8:343-350.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 343-350
    • Kazazian, H.H.1
  • 37
    • 0001861002 scopus 로고
    • Evidence for the partial dominance of recessive lethal genes in natural populations of Drosophila
    • Crow JF, Temin RG. Evidence for the partial dominance of recessive lethal genes in natural populations of Drosophila. Am Nat 1964;98:21-33.
    • (1964) Am Nat , vol.98 , pp. 21-33
    • Crow, J.F.1    Temin, R.G.2
  • 38
    • 0027511662 scopus 로고
    • How much do we know about spontaneous human mutation rates?
    • Crow JF. How much do we know about spontaneous human mutation rates? Environ Mol Mutagen 1993;21:122-129.
    • (1993) Environ Mol Mutagen , vol.21 , pp. 122-129
    • Crow, J.F.1
  • 40
    • 0024211247 scopus 로고
    • DNA, mutations and aging
    • 1988
    • Kirkwood TB. (1988) DNA, mutations and aging. Mut Res 1988:7-13.
    • (1988) Mut Res , pp. 7-13
    • Kirkwood, T.B.1
  • 41
    • 85053540700 scopus 로고
    • Genomic instability during aging of postmitotic mammalian cells
    • Macieira-Coelho A, ed. Boca Raton, FL: CRC Press
    • Gaubatz JW. Genomic instability during aging of postmitotic mammalian cells. In: Macieira-Coelho A, ed. Molecular Basis of Aging. Boca Raton, FL: CRC Press, 1995:71-135.
    • (1995) Molecular Basis of Aging , pp. 71-135
    • Gaubatz, J.W.1
  • 42
    • 0029131290 scopus 로고
    • The somatic mutation theory of aging
    • Morley AA. The somatic mutation theory of aging. Mut Res 1995;338:19-23.
    • (1995) Mut Res , vol.338 , pp. 19-23
    • Morley, A.A.1
  • 43
    • 4244160696 scopus 로고
    • DNA repair during aging
    • Macieira-Coelho A, ed. Boca Raton, FL: CRC Press
    • Niedermuller H. DNA repair during aging. In: Macieira-Coelho A, ed. Molecular Basis of Aging. Boca Raton, FL: CRC Press, 1995:137-182.
    • (1995) Molecular Basis of Aging , pp. 137-182
    • Niedermuller, H.1
  • 44
    • 0002696174 scopus 로고    scopus 로고
    • Maintaining the stability of the genome
    • Rattan SIS, Toussaiant O, eds. New York: Plenum Press
    • Burkle A. Maintaining the stability of the genome. In: Rattan SIS, Toussaiant O, eds. Molecular Gerontology, Research Status and Strategies. New York: Plenum Press, 1996:25-36.
    • (1996) Molecular Gerontology, Research Status and Strategies , pp. 25-36
    • Burkle, A.1
  • 45
    • 0037714476 scopus 로고    scopus 로고
    • Genetics of ageing and multifactorial diseases
    • Rattan SIS, Toussaiant O, eds. New York: Plenum Press
    • Slagboom PE, Knook DL. Genetics of ageing and multifactorial diseases. In: Rattan SIS, Toussaiant O, eds. Molecular Gerontology, Research Status and Strategies. New York: Plenum Press, 1996:1-14.
    • (1996) Molecular Gerontology, Research Status and Strategies , pp. 1-14
    • Slagboom, P.E.1    Knook, D.L.2
  • 46
    • 0029921311 scopus 로고    scopus 로고
    • The role of DNA damage in cellular aging: Is it time for a reassessment?
    • Norwood TH, Gray M. The role of DNA damage in cellular aging: is it time for a reassessment? Exp Gerontol 1996;31:61-68.
    • (1996) Exp Gerontol , vol.31 , pp. 61-68
    • Norwood, T.H.1    Gray, M.2
  • 47
    • 0030586979 scopus 로고    scopus 로고
    • DNA status in brain and heart as prominent co-determinant for life span? Assessing the different degrees of DNA damage, damage susceptibility, and repair capability in different organs of young and old mice
    • Zahn RK, Jaud S, Schroder H, et al. DNA status in brain and heart as prominent co-determinant for life span? Assessing the different degrees of DNA damage, damage susceptibility, and repair capability in different organs of young and old mice. Mech Ageing Dev 1996;89:79-94.
    • (1996) Mech Ageing Dev , vol.89 , pp. 79-94
    • Zahn, R.K.1    Jaud, S.2    Schroder, H.3
  • 48
    • 0030699271 scopus 로고    scopus 로고
    • Rapid accumulation of genome rearrangements in liver but not in brain of old mice
    • Dolle MET, Giese H, Hopkins CL, et al. Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet 1997;17:431-434.
    • (1997) Nat Genet , vol.17 , pp. 431-434
    • Dolle, M.E.T.1    Giese, H.2    Hopkins, C.L.3
  • 51
    • 0032544120 scopus 로고    scopus 로고
    • Mutation frequency declines during spermatogeneis in young mice but increases in old mice
    • Walter CA, Intano GW, McCarrey JR, et al. Mutation frequency declines during spermatogeneis in young mice but increases in old mice. Proc Natl Acad Sci USA 1998;95:10015-10019.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10015-10019
    • Walter, C.A.1    Intano, G.W.2    McCarrey, J.R.3
  • 52
    • 0032980501 scopus 로고    scopus 로고
    • Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants
    • Flores C, Engels W. Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants. Proc Natl Acad Sci USA 1999;96:2964-2969.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2964-2969
    • Flores, C.1    Engels, W.2
  • 53
    • 0034118947 scopus 로고    scopus 로고
    • The real Dorian Gray mouse
    • Lithgow GJ, Andersen JK. The real Dorian Gray mouse. BioEssays 2000;22:410-413.
    • (2000) BioEssays , vol.22 , pp. 410-413
    • Lithgow, G.J.1    Andersen, J.K.2
  • 56
    • 0035101436 scopus 로고    scopus 로고
    • DNA mismatch repair and cancer
    • Peltomaki P. DNA mismatch repair and cancer. Mut Res 2001;488:77-85.
    • (2001) Mut Res , vol.488 , pp. 77-85
    • Peltomaki, P.1
  • 57
    • 0035029377 scopus 로고    scopus 로고
    • DNA polymerasebeta may be the main player for defective DNA repair in aging rat neurons
    • Rao KS, Annapurna VV, Raji NS. DNA polymerasebeta may be the main player for defective DNA repair in aging rat neurons. Ann NY Acad Sci 2001;28:113-120.
    • (2001) Ann NY Acad Sci , vol.28 , pp. 113-120
    • Rao, K.S.1    Annapurna, V.V.2    Raji, N.S.3
  • 58
    • 0034894923 scopus 로고    scopus 로고
    • Levels of 8-hydroxy-2′-deoxyguanosine in cellular DNA form 12 tissues of young and old Sprague-Dawley rats
    • Schmerold I, Niedermuller H. Levels of 8-hydroxy-2′-deoxyguanosine in cellular DNA form 12 tissues of young and old Sprague-Dawley rats. Exp Gerontol 2001;8:1375-1386.
    • (2001) Exp Gerontol , vol.8 , pp. 1375-1386
    • Schmerold, I.1    Niedermuller, H.2
  • 59
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • Lin MT, Simon DK, Ahu CH, et al. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet 2002; 11:133-145.
    • (2002) Hum Mol Genet , vol.11 , pp. 133-145
    • Lin, M.T.1    Simon, D.K.2    Ahu, C.H.3
  • 60
    • 0037081784 scopus 로고    scopus 로고
    • Somatic expansion behavior of the (CTG)(n) repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins
    • van Den Broek WJ, Nelen MR, Wansink DG, et al. Somatic expansion behavior of the (CTG)(n) repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins. Hum Mol Genet 2002;11:191-198.
    • (2002) Hum Mol Genet , vol.11 , pp. 191-198
    • Van Den Broek, W.J.1    Nelen, M.R.2    Wansink, D.G.3
  • 61
    • 0033800838 scopus 로고    scopus 로고
    • Stress and transposable elements: Co-evolution or useful parasites?
    • Capy P, Gasperi G, Biemont C, et al. Stress and transposable elements: co-evolution or useful parasites? Heredity 2000;85:101-106.
    • (2000) Heredity , vol.85 , pp. 101-106
    • Capy, P.1    Gasperi, G.2    Biemont, C.3
  • 62
    • 0034594978 scopus 로고    scopus 로고
    • A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
    • Tanaka H, Arakawa H, Yamaguchi T, et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 2000;404:42-49.
    • (2000) Nature , vol.404 , pp. 42-49
    • Tanaka, H.1    Arakawa, H.2    Yamaguchi, T.3
  • 63
    • 0037011958 scopus 로고    scopus 로고
    • p53 mutant mice that display early ageing-associated phenotypes
    • Tyner SD, Venkatachaiam S, Choi J, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002;415:45-53.
    • (2002) Nature , vol.415 , pp. 45-53
    • Tyner, S.D.1    Venkatachaiam, S.2    Choi, J.3
  • 64
    • 0028220114 scopus 로고
    • Extension of life-span by over-expression of superoxidedismutase and catalase in Drosophila melanogaster
    • Orr WC, Sohal RS. Extension of life-span by over-expression of superoxidedismutase and catalase in Drosophila melanogaster. Science 1994;263:1128-1130.
    • (1994) Science , vol.263 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 65
    • 0031864164 scopus 로고    scopus 로고
    • Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
    • Parkes TL, Elia AJ, Dickinson D, et al. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 1998;19:171-174.
    • (1998) Nat Genet , vol.19 , pp. 171-174
    • Parkes, T.L.1    Elia, A.J.2    Dickinson, D.3
  • 66
    • 0032908347 scopus 로고    scopus 로고
    • FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
    • Sun J, Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 1999;19:216-228.
    • (1999) Mol Cell Biol , vol.19 , pp. 216-228
    • Sun, J.1    Tower, J.2
  • 67
    • 0033659765 scopus 로고    scopus 로고
    • Targeted neuronal gene expression and longevity in Drosophila
    • Phillips JP, Parkes T, Hilliker AJ. Targeted neuronal gene expression and longevity in Drosophila. Exp Gerontol 2000;35:1157-1164.
    • (2000) Exp Gerontol , vol.35 , pp. 1157-1164
    • Phillips, J.P.1    Parkes, T.2    Hilliker, A.J.3
  • 68
    • 0035916385 scopus 로고    scopus 로고
    • Mutation frequency is reduced in the cerebellum of Big Blue mice overexpressing a human wild-type SOD1 gene
    • Kunishige M, Hill KA, Riemer AM, et al. Mutation frequency is reduced in the cerebellum of Big Blue mice overexpressing a human wild-type SOD1 gene. Mut Res 2001;473:139-149.
    • (2001) Mut Res , vol.473 , pp. 139-149
    • Kunishige, M.1    Hill, K.A.2    Riemer, A.M.3
  • 69
    • 0031705467 scopus 로고    scopus 로고
    • Attenuation of age-dependent oxidative damage to DNA and protein in brainstem of Tg Cu/Zn SOD mice
    • Cardozo-Pelaez R, Song S, Parthasarathy A, et al. Attenuation of age-dependent oxidative damage to DNA and protein in brainstem of Tg Cu/Zn SOD mice. Neurobiol Aging 1998;19:311-316.
    • (1998) Neurobiol Aging , vol.19 , pp. 311-316
    • Cardozo-Pelaez, R.1    Song, S.2    Parthasarathy, A.3
  • 70
    • 0030038103 scopus 로고    scopus 로고
    • Oxidation stress, caloric restriction, and aging
    • Sohal RS, Weindruch R. Oxidation stress, caloric restriction, and aging. Science 1996;273:59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 71
    • 0038390582 scopus 로고
    • Effect of vitamin E on survivorship of a DNA repair deficient mutant of Drosophila melanogaster
    • Adelman RC, Roberts J, Baker GT III, et al. New York: Alan R. Liss, Inc
    • Daly RN, Jacobson M, Cunningham ET, et al. Effect of vitamin E on survivorship of a DNA repair deficient mutant of Drosophila melanogaster. In: Adelman RC, Roberts J, Baker GT III, et al. Neural Regulatory Mechanisms during Aging. New York: Alan R. Liss, Inc., 1980:209-210.
    • (1980) Neural Regulatory Mechanisms During Aging , pp. 209-210
    • Daly, R.N.1    Jacobson, M.2    Cunningham, E.T.3
  • 72
    • 0020505366 scopus 로고
    • Role of metabolic rate and DNA-repair in Drosophila aging: Implications for the mitochondrial mutation theory of aging
    • Miquel J, Binnard R, Fleming JE. Role of metabolic rate and DNA-repair in Drosophila aging: implications for the mitochondrial mutation theory of aging. Exp Gerontol 1983;18:167-171.
    • (1983) Exp Gerontol , vol.18 , pp. 167-171
    • Miquel, J.1    Binnard, R.2    Fleming, J.E.3
  • 73
    • 0027173469 scopus 로고
    • A correlation between DNA repair capacity and longevity in adult Drosophila melanogaster
    • Whitehead I, Grigliatti TA. A correlation between DNA repair capacity and longevity in adult Drosophila melanogaster. J Gerontol 1993;48:B124-B132.
    • (1993) J Gerontol , vol.48
    • Whitehead, I.1    Grigliatti, T.A.2
  • 74
    • 0037123638 scopus 로고    scopus 로고
    • Premature aging in mice deficient in DNA repair and transcription
    • de Boer J, Andressoo JO, de Wit J, et al. Premature aging in mice deficient in DNA repair and transcription. Science 2001;296:1276-1279.
    • (2001) Science , vol.296 , pp. 1276-1279
    • De Boer, J.1    Andressoo, J.O.2    De Wit, J.3
  • 75
    • 0032085368 scopus 로고    scopus 로고
    • Accelerated accumulation of somatic mutations in the senescence-accelerated mouse
    • Odagiri Y, Uchida H, Hosokawa M, et al. Accelerated accumulation of somatic mutations in the senescence-accelerated mouse. Nat Genet 1998;19:116-117.
    • (1998) Nat Genet , vol.19 , pp. 116-117
    • Odagiri, Y.1    Uchida, H.2    Hosokawa, M.3
  • 76
    • 0032827888 scopus 로고    scopus 로고
    • Deletion of Ku86 causes early onset of senescence in mice
    • Vogel H, Lim D, Karsenty G, et al. Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci USA 1999;96:10770-10775.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10770-10775
    • Vogel, H.1    Lim, D.2    Karsenty, G.3
  • 77
    • 0029099989 scopus 로고
    • Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
    • Baker SM, Bronner CE, Zhang L, et al. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 1995;82:309-319.
    • (1995) Cell , vol.82 , pp. 309-319
    • Baker, S.M.1    Bronner, C.E.2    Zhang, L.3
  • 78
    • 15844367099 scopus 로고    scopus 로고
    • Meiotic pachytene arrest in MLH1-defective mice
    • Edelmann W, Cohen PE, Kane M, et al. Meiotic pachytene arrest in MLH1-defective mice. Cell 1996;85:1125-1134.
    • (1996) Cell , vol.85 , pp. 1125-1134
    • Edelmann, W.1    Cohen, P.E.2    Kane, M.3
  • 79
    • 0029848286 scopus 로고    scopus 로고
    • Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
    • Elson A, Wang Y, Daugherty CJ, et al. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci USA 1996;93:13084-13089.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13084-13089
    • Elson, A.1    Wang, Y.2    Daugherty, C.J.3
  • 80
    • 0036727417 scopus 로고    scopus 로고
    • Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer
    • Springer K, Ahangar F, Scott SP, et al. Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nat Genet 2002;32:185-190.
    • (2002) Nat Genet , vol.32 , pp. 185-190
    • Springer, K.1    Ahangar, F.2    Scott, S.P.3
  • 82
    • 15844409553 scopus 로고    scopus 로고
    • Positional cloning of the Werner's syndrome gene
    • Yu C, Oshima J, Fu Y, et al. Positional cloning of the Werner's syndrome gene. Science 1996;272:258-262.
    • (1996) Science , vol.272 , pp. 258-262
    • Yu, C.1    Oshima, J.2    Fu, Y.3
  • 83
    • 0032940047 scopus 로고    scopus 로고
    • Human DNA repair systems: An overview
    • Yu Z, Chen J, Ford BN, et al. Human DNA repair systems: an overview. Environ Mol Mutagen 1999; 33:3-20.
    • (1999) Environ Mol Mutagen , vol.33 , pp. 3-20
    • Yu, Z.1    Chen, J.2    Ford, B.N.3
  • 84
    • 0031927305 scopus 로고    scopus 로고
    • Is Fanconi anemia caused by a defect in the processing of DNA damage?
    • Buchwald M, Moustacchi E. Is Fanconi anemia caused by a defect in the processing of DNA damage? Mut Res 1998;408:75-90.
    • (1998) Mut Res , vol.408 , pp. 75-90
    • Buchwald, M.1    Moustacchi, E.2
  • 86
    • 0034953044 scopus 로고    scopus 로고
    • Werner syndrome: Genetic and molecular basis of a premating aging disorder
    • Lebel M. Werner syndrome: genetic and molecular basis of a premating aging disorder. Cell Mol Life Sci 2001;7:857-867.
    • (2001) Cell Mol Life Sci , vol.7 , pp. 857-867
    • Lebel, M.1
  • 88
    • 0037197870 scopus 로고    scopus 로고
    • Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster
    • Pletcher SD, Macdonald SJ, Marguerie R, et al. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol 2002;12:712-723.
    • (2002) Curr Biol , vol.12 , pp. 712-723
    • Pletcher, S.D.1    Macdonald, S.J.2    Marguerie, R.3
  • 89
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee C, Klopp RG, Weindruch R, et al. Gene expression profile of aging and its retardation by caloric restriction. Science 1999;285:1390-1393.
    • (1999) Science , vol.285 , pp. 1390-1393
    • Lee, C.1    Klopp, R.G.2    Weindruch, R.3
  • 90
    • 0035942222 scopus 로고    scopus 로고
    • Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
    • Kayo T, Allison DB, Weindruch R, et al. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA 2001;98:5093-5098.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5093-5098
    • Kayo, T.1    Allison, D.B.2    Weindruch, R.3
  • 91
    • 0025287570 scopus 로고
    • Hypothesis: Are transposons a cause of ageing?
    • Murray V. Hypothesis: are transposons a cause of ageing? Mut Res 1990;237:59-63.
    • (1990) Mut Res , vol.237 , pp. 59-63
    • Murray, V.1
  • 92
    • 0030826910 scopus 로고    scopus 로고
    • Genetic regulation of aging
    • Osiewacz HD. Genetic regulation of aging. J Mol Med 1997;75:715-727.
    • (1997) J Mol Med , vol.75 , pp. 715-727
    • Osiewacz, H.D.1
  • 93
    • 0027070562 scopus 로고
    • Transposable elements as a factor in the aging of Drosophila melanogaster
    • Driver CJI, McKechnie SW. Transposable elements as a factor in the aging of Drosophila melanogaster. Annu NY Acad Sci 1992;673:83-91.
    • (1992) Annu NY Acad Sci , vol.673 , pp. 83-91
    • Driver, C.J.I.1    McKechnie, S.W.2
  • 94
    • 0027017849 scopus 로고
    • Transposable DNA elements and life history traits. I. Transposition of P DNA elements in somatic cells reduces the lifespan of Drosophila melanogaster
    • Woodruff RC. Transposable DNA elements and life history traits. I. Transposition of P DNA elements in somatic cells reduces the lifespan of Drosophila melanogaster. Genetica 1992;86:143-154.
    • (1992) Genetica , vol.86 , pp. 143-154
    • Woodruff, R.C.1
  • 95
    • 0029102124 scopus 로고
    • P DNA element movement in somatic cells reduces lifespan in Drosophila melanogaster: Evidence in support of the somatic mutation theory of aging
    • Woodruff RC, Nikitin AG. P DNA element movement in somatic cells reduces lifespan in Drosophila melanogaster: evidence in support of the somatic mutation theory of aging. Mut Res 1995;338:35-42.
    • (1995) Mut Res , vol.338 , pp. 35-42
    • Woodruff, R.C.1    Nikitin, A.G.2
  • 96
    • 0033287206 scopus 로고    scopus 로고
    • Transposable DNA elements and life history traits. II. Transposition of P DNA elements in somatic cells reduces fitness, mating activity, and locomotion of Drosophila melanogaster
    • Woodruff RC, Thompson JN Jr, Barker JSF, et al. Transposable DNA elements and life history traits. II. Transposition of P DNA elements in somatic cells reduces fitness, mating activity, and locomotion of Drosophila melanogaster. Genetica 1999;107:261-269.
    • (1999) Genetica , vol.107 , pp. 261-269
    • Woodruff, R.C.1    Thompson J.N., Jr.2    Barker, J.S.F.3
  • 97
    • 0029154550 scopus 로고
    • Somatic movement of the mariner transposable element and lifespan of Drosophila species
    • Nikitin AG, Woodruff RC. Somatic movement of the mariner transposable element and lifespan of Drosophila species. Mut Res 1995;338:43-49.
    • (1995) Mut Res , vol.338 , pp. 43-49
    • Nikitin, A.G.1    Woodruff, R.C.2
  • 98
    • 0031622681 scopus 로고    scopus 로고
    • Retrotransposable integration of mobile genetic elements in human diseases
    • Miki Y. Retrotransposable integration of mobile genetic elements in human diseases. J Hum Genet 1998; 43:77-84.
    • (1998) J Hum Genet , vol.43 , pp. 77-84
    • Miki, Y.1
  • 99
    • 0034023123 scopus 로고    scopus 로고
    • Impact of transposable elements on the human genome
    • Deragon JM, Capy P. Impact of transposable elements on the human genome. Ann Med 2000;32:264-273.
    • (2000) Ann Med , vol.32 , pp. 264-273
    • Deragon, J.M.1    Capy, P.2
  • 100
    • 0035500898 scopus 로고    scopus 로고
    • Transposable elements are found in a large number of human protein-coding genes
    • Nekrutenko A, Li W-H. Transposable elements are found in a large number of human protein-coding genes. Trends Genet 2001;17:619-621.
    • (2001) Trends Genet , vol.17 , pp. 619-621
    • Nekrutenko, A.1    Li, W.-H.2
  • 101
    • 0033103644 scopus 로고    scopus 로고
    • Oxidative DNA damage, antioxidants, and cancer
    • Collins AR. Oxidative DNA damage, antioxidants, and cancer. BioEssays 1999;21:238-246.
    • (1999) BioEssays , vol.21 , pp. 238-246
    • Collins, A.R.1
  • 103
    • 2442501607 scopus 로고    scopus 로고
    • Caloric restriction and aging: Studies in rodents and primates
    • Morley JE, Armbrecht HJ, Coe RM, et al., eds. New York: Springer
    • Wanagat J, Weindruch R. Caloric restriction and aging: studies in rodents and primates. In: Morley JE, Armbrecht HJ, Coe RM, et al., eds. The Science of Geriatrics. New York: Springer, 2000:153-165.
    • (2000) The Science of Geriatrics , pp. 153-165
    • Wanagat, J.1    Weindruch, R.2
  • 105
    • 0033798101 scopus 로고    scopus 로고
    • Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation
    • Karbownik M, Reiter RJ, Qi W, et al. Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation Mol Cell Biochem 2000;211:137-144.
    • (2000) Mol Cell Biochem , vol.211 , pp. 137-144
    • Karbownik, M.1    Reiter, R.J.2    Qi, W.3
  • 106
    • 0036719572 scopus 로고    scopus 로고
    • Are vitamin and mineral deficiencies a major cancer risk?
    • Ames BN, Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer 2002;2:694-704.
    • (2002) Nat Rev Cancer , vol.2 , pp. 694-704
    • Ames, B.N.1    Wakimoto, P.2
  • 107
    • 0035996802 scopus 로고    scopus 로고
    • Is human aging still mysterious enough to be left only to scientists?
    • de Gray ADNJ, Baynes JW, Berd D, et al. Is human aging still mysterious enough to be left only to scientists? BioEssays 2002;24:667-676.
    • (2002) BioEssays , vol.24 , pp. 667-676
    • De Gray, A.D.N.J.1    Baynes, J.W.2    Berd, D.3
  • 108
    • 0037008501 scopus 로고    scopus 로고
    • Biomarkers of caloric restriction may predict longevity in humans
    • Roth GS, Lane MA, Ingram DK, et al. Biomarkers of caloric restriction may predict longevity in humans. Science 2002;297:811.
    • (2002) Science , vol.297 , pp. 811
    • Roth, G.S.1    Lane, M.A.2    Ingram, D.K.3
  • 109
    • 0031043321 scopus 로고    scopus 로고
    • Somatic mutations and aging: Cause or effect?
    • Barnett YA. Somatic mutations and aging: cause or effect? Biochem Soc Trans 1997;25:332-335.
    • (1997) Biochem Soc Trans , vol.25 , pp. 332-335
    • Barnett, Y.A.1
  • 111
    • 0002535644 scopus 로고    scopus 로고
    • Population study of mortality and longevity with Gompertzian analysis
    • Yu BP, ed. Boca Raton, FL: CRC Press
    • Carey JR. Population study of mortality and longevity with Gompertzian analysis. In: Yu BP, ed. Method in Aging Research. Boca Raton, FL: CRC Press, 1999:3-24.
    • (1999) Method in Aging Research , pp. 3-24
    • Carey, J.R.1
  • 112
  • 113
    • 0033611468 scopus 로고    scopus 로고
    • The odds of losing at genetic roulette
    • Crow JF. The odds of losing at genetic roulette. Nature 1999;397:292-294.
    • (1999) Nature , vol.397 , pp. 292-294
    • Crow, J.F.1
  • 114
    • 0036346458 scopus 로고    scopus 로고
    • Generation of genetically altered mouse models for aging studies
    • Treuting PM, Hopkins HC, Ware CA, et al. Generation of genetically altered mouse models for aging studies. Exp Mol Pathol 2002;72:49-55.
    • (2002) Exp Mol Pathol , vol.72 , pp. 49-55
    • Treuting, P.M.1    Hopkins, H.C.2    Ware, C.A.3
  • 115
    • 0002129633 scopus 로고
    • The genetic structure of natural populations of Drosophila melanogaster. I. Spontaneous mutation rate of polygenes controlling viability
    • Mukai T. The genetic structure of natural populations of Drosophila melanogaster. I. Spontaneous mutation rate of polygenes controlling viability. Genetics 1964;50:1-19.
    • (1964) Genetics , vol.50 , pp. 1-19
    • Mukai, T.1
  • 116
    • 0037144601 scopus 로고    scopus 로고
    • Enhanced tumor formation in mice heterozygous for Blm mutation
    • Goss RH, Risinger MA, Kordich JJ, et al. Enhanced tumor formation in mice heterozygous for Blm mutation. Science 2002;297:2051-2053.
    • (2002) Science , vol.297 , pp. 2051-2053
    • Goss, R.H.1    Risinger, M.A.2    Kordich, J.J.3
  • 117
    • 0036727417 scopus 로고    scopus 로고
    • Mice heterozygous for mutation in Atm, the gene involved in axtaxia-telangiectasia, have heightened susceptibility to cancer
    • , Spring K, Ahangari F, Scott SP, et al. Mice heterozygous for mutation in Atm, the gene involved in axtaxia-telangiectasia, have heightened susceptibility to cancer. Nat Genet 2002;32:185-190.
    • (2002) Nat Genet , vol.32 , pp. 185-190
    • Spring, K.1    Ahangari, F.2    Scott, S.P.3
  • 118
    • 18544386262 scopus 로고    scopus 로고
    • BLM heterozygosity and the risk of colorectal cancer
    • Gruber SB, Ellis NA, Rennert G, et al. BLM heterozygosity and the risk of colorectal cancer. Science 2002;297:2013.
    • (2002) Science , vol.297 , pp. 2013
    • Gruber, S.B.1    Ellis, N.A.2    Rennert, G.3
  • 119
    • 72949134211 scopus 로고
    • The modification by x-irradiation of the life span of haploids and diploids of the wasp, Harbrobracon SP
    • Clark AM, Rubin MA. The modification by x-irradiation of the life span of haploids and diploids of the wasp, Harbrobracon SP. Radiat Biol 1961;15:244-253.
    • (1961) Radiat Biol , vol.15 , pp. 244-253
    • Clark, A.M.1    Rubin, M.A.2
  • 120
    • 0017598253 scopus 로고
    • Evidence for dosage compensation in parthenogenetic Hymenoptera
    • Rasch EM, Cassidy JD, King RC. Evidence for dosage compensation in parthenogenetic Hymenoptera. Chromosoma 1977;59:323-340.
    • (1977) Chromosoma , vol.59 , pp. 323-340
    • Rasch, E.M.1    Cassidy, J.D.2    King, R.C.3
  • 121
    • 0038728745 scopus 로고
    • The spinning glands of impaternate (male) Harbrobracon larvae: Morphology and cytology
    • Grosch DS. The spinning glands of impaternate (male) Harbrobracon larvae: morphology and cytology. J Morphol 1952;91:221-236.
    • (1952) J Morphol , vol.91 , pp. 221-236
    • Grosch, D.S.1
  • 122
    • 0038728744 scopus 로고
    • Cytology and cytogenetics
    • Rinderer TE, ed. New York: Academic Press
    • Milne CP Jr. Cytology and cytogenetics. In: Rinderer TE, ed. Bee Genetics and Breeding. New York: Academic Press, 1986:205-233.
    • (1986) Bee Genetics and Breeding , pp. 205-233
    • Milne C.P., Jr.1
  • 123
    • 0001929473 scopus 로고
    • Genetics of bees others than Apis mellifera
    • Rinderer TE, ed. New York: Academic Press
    • Moritz RFA. Genetics of bees others than Apis mellifera. In: Rinderer TE, ed. Bee Genetics and Breeding. New York: Academic Press, 1986:121-154.
    • (1986) Bee Genetics and Breeding , pp. 121-154
    • Moritz, R.F.A.1
  • 124
    • 0002066473 scopus 로고
    • Sex determination
    • Rinderer TE, ed. New York: Academic Press
    • Woyke J. Sex determination. In: Rinderer TE, ed. Bee Genetics and Breeding. New York: Academic Press, 1986:91-119.
    • (1986) Bee Genetics and Breeding , pp. 91-119
    • Woyke, J.1
  • 125
    • 0018340529 scopus 로고
    • Genetic control of chromosome breakage and rejoining in Drosophila melanogaster: Spontaneous chromosome aberrations in X-linked mutants defective in DNA metabolism
    • Gatti M. Genetic control of chromosome breakage and rejoining in Drosophila melanogaster: spontaneous chromosome aberrations in X-linked mutants defective in DNA metabolism. Proc Natl Acad Sci USA 1979;76:1377-1381.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 1377-1381
    • Gatti, M.1
  • 126
    • 0038728743 scopus 로고
    • The effects of ionizing radiation on the longevity of ploidy types in the wasp Mormoniella vitripennis
    • Clark AM, Cole KW. The effects of ionizing radiation on the longevity of ploidy types in the wasp Mormoniella vitripennis. Exp Gerontol 1967;2:89-95.
    • (1967) Exp Gerontol , vol.2 , pp. 89-95
    • Clark, A.M.1    Cole, K.W.2
  • 127
    • 0034303523 scopus 로고    scopus 로고
    • The origins, patterns and implications of human spontaneous mutation
    • Crow JF. The origins, patterns and implications of human spontaneous mutation. Nat Rev Genet 2000;1:40-47.
    • (2000) Nat Rev Genet , vol.1 , pp. 40-47
    • Crow, J.F.1
  • 129
    • 0030957435 scopus 로고    scopus 로고
    • Parental age at conception and offspring longevity
    • Gavrilov LA, Gavrilova NS. Parental age at conception and offspring longevity. Rev Clin Gerontol 1997; 7:5-12.
    • (1997) Rev Clin Gerontol , vol.7 , pp. 5-12
    • Gavrilov, L.A.1    Gavrilova, N.S.2
  • 130
    • 0033166885 scopus 로고    scopus 로고
    • Spontaneous mutation in man
    • Crow JF. Spontaneous mutation in man. Mut Res 1999;437:5-9.
    • (1999) Mut Res , vol.437 , pp. 5-9
    • Crow, J.F.1
  • 131
    • 0034703650 scopus 로고    scopus 로고
    • Maternal and grandmaternal age influence offspring fitness in Drosophila
    • Hercus MJ, Hoffmann AA. Maternal and grandmaternal age influence offspring fitness in Drosophila. Proc R Soc Biol Sci 2000;267:2105-2110.
    • (2000) Proc R Soc Biol Sci , vol.267 , pp. 2105-2110
    • Hercus, M.J.1    Hoffmann, A.A.2
  • 132
    • 0034763020 scopus 로고    scopus 로고
    • Decline in offspring viability as a manifestation of aging in Drosophila melanogaster
    • Kern S, Ackermann M, Stearns SC, et al. Decline in offspring viability as a manifestation of aging in Drosophila melanogaster. Evolution 2001;55:1822-1831.
    • (2001) Evolution , vol.55 , pp. 1822-1831
    • Kern, S.1    Ackermann, M.2    Stearns, S.C.3
  • 133
    • 0035987377 scopus 로고    scopus 로고
    • The role of parental age effects on the evolution of aging
    • Priest NK, Mackowiak B, Promislow DEL. The role of parental age effects on the evolution of aging. Evolution 2002;56:927-935.
    • (2002) Evolution , vol.56 , pp. 927-935
    • Priest, N.K.1    Mackowiak, B.2    Promislow, D.E.L.3
  • 134
    • 0036157107 scopus 로고    scopus 로고
    • Postovulatory aging of oocytes decreases reproductive fitness and longevity of offspring
    • Tarin JJ, Perez-Albala S, Perez-Hoyos S, et al. Postovulatory aging of oocytes decreases reproductive fitness and longevity of offspring. Biol Reprod 2002; 66:495-499.
    • (2002) Biol Reprod , vol.66 , pp. 495-499
    • Tarin, J.J.1    Perez-Albala, S.2    Perez-Hoyos, S.3
  • 136
    • 0029994356 scopus 로고    scopus 로고
    • Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence
    • Charlesworth B, Hughes KA. Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence. Proc Natl Acad Sci USA 1996;93:6140-6145.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6140-6145
    • Charlesworth, B.1    Hughes, K.A.2
  • 137
    • 84993918993 scopus 로고
    • Have premeiotic clusters of mutation been overlooked in evolutionary theory?
    • Woodruff RC, Thompson JN Jr. Have premeiotic clusters of mutation been overlooked in evolutionary theory? J Evol Biol 1992;5:457-464.
    • (1992) J Evol Biol , vol.5 , pp. 457-464
    • Woodruff, R.C.1    Thompson J.N., Jr.2
  • 138
    • 0030267842 scopus 로고    scopus 로고
    • Clusters of new mutations in the evolutionary landscape
    • Woodruff RC, Huai H, Thompson JN Jr. Clusters of new mutations in the evolutionary landscape. Genetica 1996;98:149-160.
    • (1996) Genetica , vol.98 , pp. 149-160
    • Woodruff, R.C.1    Huai, H.2    Thompson J.N., Jr.3
  • 140
    • 7344259634 scopus 로고    scopus 로고
    • The developmental basis for germline mosaicism in mouse and Drosophila melanogaster
    • Drost JB, Lee WR. The developmental basis for germline mosaicism in mouse and Drosophila melanogaster. Genetica 1998;102/103:421-443.
    • (1998) Genetica , vol.102-103 , pp. 421-443
    • Drost, J.B.1    Lee, W.R.2
  • 141
    • 7344249037 scopus 로고    scopus 로고
    • Clusters of new identical mutants and the fate of underdominant mutations
    • Huai H, Woodruff RC. Clusters of new identical mutants and the fate of underdominant mutations. Genetica 1998;102/103:489-505.
    • (1998) Genetica , vol.102-103 , pp. 489-505
    • Huai, H.1    Woodruff, R.C.2
  • 142
    • 0031825169 scopus 로고    scopus 로고
    • Major impacts of gonadal mosaicism on hereditary risk estimation, origin of hereditary diseases, and evolution
    • Selby PB. Major impacts of gonadal mosaicism on hereditary risk estimation, origin of hereditary diseases, and evolution. Genetica 1998;102/103:445-462.
    • (1998) Genetica , vol.102-103 , pp. 445-462
    • Selby, P.B.1
  • 143
    • 0030884402 scopus 로고    scopus 로고
    • Clusters of identical new mutations can account for the "overdispersed" molecular clock
    • Huai H, Woodruff RC. Clusters of identical new mutations can account for the "overdispersed" molecular clock. Genetics 1997;147:339-348.
    • (1997) Genetics , vol.147 , pp. 339-348
    • Huai, H.1    Woodruff, R.C.2
  • 144
    • 0038052267 scopus 로고    scopus 로고
    • The long good-bye
    • Letter
    • Woodruff RC. The Long Good-Bye [Letter] Discover 1999;Oct:18.
    • (1999) Discover , vol.OCT , pp. 18
    • Woodruff, R.C.1
  • 145
    • 0032509440 scopus 로고    scopus 로고
    • Eight calves cloned from somatic cells of a single adult
    • Kato Y, Tani T, Sotomaru Y, et al. Eight calves cloned from somatic cells of a single adult. Science 1998;282:2095-2098.
    • (1998) Science , vol.282 , pp. 2095-2098
    • Kato, Y.1    Tani, T.2    Sotomaru, Y.3
  • 146
    • 18544390839 scopus 로고    scopus 로고
    • Early death of mice cloned from somatic cells
    • Ogonuki N, Inoue K, Yamamoto Y, et al. Early death of mice cloned from somatic cells. Nat Genet 2002; 30:253-254.
    • (2002) Nat Genet , vol.30 , pp. 253-254
    • Ogonuki, N.1    Inoue, K.2    Yamamoto, Y.3
  • 147
    • 0036792031 scopus 로고    scopus 로고
    • Abnormal gene expression incloned mice derived from embryonic stem cell and cumulus cell nuclei
    • Humpherys D, Eggan K, Akutsu H, et al. Abnormal gene expression incloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci USA 2002;99:12889-12894.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12889-12894
    • Humpherys, D.1    Eggan, K.2    Akutsu, H.3
  • 148
    • 0036127638 scopus 로고    scopus 로고
    • Cloned mice have an obese phenotype not transmitted to their offspring
    • Tamashiro KL, Wakayama T, Akutsu H, et al. Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med 2002;8:262-267.
    • (2002) Nat Med , vol.8 , pp. 262-267
    • Tamashiro, K.L.1    Wakayama, T.2    Akutsu, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.