Clusters of identical new mutations can account for the 'overdispersed' molecular clock

Genetics

Volumn 147, Issue 1, 1997, Pages 339-348

  Huai, Haiying ^a   Woodruff, R C ^a  

^a BOWLING GREEN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; GENE CLUSTER; GENETIC VARIABILITY; GERM CELL; MEIOSIS; MOLECULAR GENETICS; MOLECULAR MODEL; PRIORITY JOURNAL;

EID: 0030884402     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1093/genetics/147.1.339     Document Type: Article

References (38)

1. AUERBACH, C., 1962 Mutation: An Introduction to Research on Mutagenesis. Part I. Methods. Oliver and Boyd, Edinburgh.
2. BRIDGES, P. J., 1994 The Calculation of Genetic Risks. The Johns Hopkins University Press, Baltimore.
3. CHARLESWORTH, D., B. CHARLESWORTH and M. T. MORGAN, 1995 The pattern of neutral molecular variation under the background selection model. Genetics 141: 1619-1632.
4. COOPER, D. N., and M. KRAWCZAK, 1993 Human Gene Mutation. BIOS Scientific Publishers Limited, Oxford.
5. CROW, J. F., and M. KIMURA, 1970 An Introduction to Population Genetics Theory. Burgess Publishing Company, Minneapolis, MN.
6. DROST, J. B., and W. R. LEE, 1995 Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among Drosophila, mouse and human. Environ. Mol. Mutagen. 25 (Suppl. 26): 48-64.
7. EASTEAL, S., C. COLLET and D. BETTY, 1995 The Mammalian Molecular Clock. Landes, Austin, TX.
8. FELLER, W., 1968 An Introduction to Probability Theory and Its Applications, Vol. 1, Ed. 3. Wiley, New York.
9. FURUSAWA, M., and H. DOI, 1992 Promotion of evolution: disparity in the frequency of strand-specific misreading between the lagging and leading DNA strands enhances disproportionate accumulation of mutations. J. Theoret. Biol. 157: 127-133.
10. FRANKHAM, R., 1995 Effective population size / adult population size ratios in wildlife: a review. Genet. Res. 66: 95-107.
11. GILLESPIE, J. H., 1984 The molecular clock may be an episodic clock. Proc. Natl. Acad. Sci. USA 81: 8009-8013.
12. GILLESPIE, J. H., 1986 Rates of molecular evolution. Annu. Rev. Ecol. Syst. 17: 637-665.
13. GILLESPIE, J. H., 1991 The Causes of Molecular Evolution, Oxford University Press, Oxford.
14. GILLESPIE, J. H., 1994 Alternatives to the neutral theory, pp. 1-17 in Non-Neutral Evolution: Theories and Molecular Data., edited by G. B. GOLDING. Chapman & Hall, New York.
15. GOLDING, G. B., 1987 Multiple substitutions create biased estimates of divergence times and small increase in the variance to mean ratio. Heredity 58: 331-339.
16. GOLDMAN, N., 1994 Variance to mean ratio, R(t), for Poisson processes on phylogenetic trees. Mol. Phylogenet. Evol. 3: 230-239.
17. HARTL, D. L., 1971 Recurrence risks for germinal mosacis. Am. J. Hum. Genet. 23: 124-134.
18. IWASA, Y., 1993 Overdispersed molecular evolution in constant environments. J. Theor. Biol. 164: 373-93.
19. KIMURA, M., 1983 The Neutral Theory of Molecular Evolution. Cambridge University Press, Cambridge.
20. LANGLEY, C. H., and W. M. FITCH, 1974 An estimation of the constancy of the rate of molecular evolution. J. Mol. Evol. 3: 161-177.
21. MULLER, H. J., 1954 The nature of the genetic effects produced by radiation, pp. 351-473 in Radiation Biology, edited by A. HOLLAENDER. McGraw-Hill, New York.
22. OCHMAN, H., and A. C. WILSON, 1987 Evolution in bacteria: evidence for a universal substitution rate in cellular genomes. J. Mol. Evol. 26: 74-86.
23. OHTA, T., 1995 Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory. J. Mol. Evol. 40: 56-63.
24. OHTA, T., and M. KIMURA, 1971 On the constancy of the evolutionary rate of cistrons. J. Mol. Evol. 1: 18-25.
25. OHTA, T., and H. TACHIDA, 1990 Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution. Genetics 126: 219-229.
26. RUSSELL, L. B., 1964 Genetic and functional mosaicism in the mouse, pp. 153-181 in The Role of Chromosomes in Development, edited by M. LOCKE. Academic Press, New York.
27. RUSSELL, L. B., and U. L. RUSSELL, 1996 Spontaneous mutations recovered as mosaics in the mouse specific-locus test. Proc. Natl. Acad. Sci. USA 93: 13072-13077.
28. SULSTON, J. E., E. SCHIERENBERG, J. G. WHITE and J. N. THOMPSON. 1983 The embryonic cell lineage of the Nematode Caenorhabditis elegans. Dev. Biol. 100: 64-119.
29. TACHIDA, H., 1991 A study on a nearly neutral mutation model in finite populations. Genetics 128: 183-192.
30. TAKAHATA, N., 1987 On the overdispersed molecular clock. Genetics 116: 169-179.
31. TAKAHATA, N., 1991 Statistical models of the overdispersed molecular clock. Theoret. Popul. Biol. 39: 329-344.
32. VEAUTE, X., and R. P. P. FUCHS, 1993 Greater susceptibility to mutations in lagging strand of DNA replication in Escherichia coli than in leading strand. Science 261: 598-600.
33. WADA, K, H. DOI, S. TANAKA, Y. WADA and M. FURUSAWA, 1993 A neo-Darwinian algorithm: asymmetrical mutations due to semiconservative DNA-type replication promote evolution. Proc. Natl. Acad. Sci. USA 90: 11934-11938.
34. WIJSMAN, E. M., 1991 Recurrence risk of a new dominant mutation in children of unaffected parents. Am. J. Hum. Genet. 48: 654-661.
35. WOODRUFF, R. C., and J. N. THOMPSON, JR., 1992 Have premeiotic clusters of mutation been overlooked in evolutionary theory? J. Evol. Biol. 5: 457-464.
36. WOODRUFF, R. C., H. HUAI and J. N. THOMPSON, JR., 1996 Clusters of identical new mutation in the evolutionary landscape. Genetica 98: 149-160.
37. WRIGHT, S., 1938 Size of population and breeding structure in relation to evolution. Science 87: 430-431.
38. YOUNG, I. D., 1991 Introduction to Risk Calculations in Genetic Consulting. Oxford University Press, Oxford.