DNA status in brain and heart as prominent co-determinant for life span? Assessing the different degrees of DNA damage, damage susceptibility, and repair capability in different organs of young and old mice

Mechanisms of Ageing and Development

Volumn 89, Issue 2, 1996, Pages 79-94

  Zahn, Rudolf K ^a,b   Jaud, Susanne ^a   Schröder, Heinz Christof ^a   Zahn Daimler, Gertrud ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Arbeitskreis Molec M   (Germany)

Author keywords

Alkali labile sites; Co determinant for life span; Cross links; Damage susceptibility; DNA strand bleak; Repair

Indexed keywords

DNA; NITROQUINOLINE DERIVATIVE; PROTEINASE;

ANIMAL TISSUE; ARTICLE; ARTIFACT; BRAIN; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; FEMALE; HEART; LIFESPAN; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

EID: 0030586979     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/0047-6374(96)01738-1     Document Type: Article

References (36)

1. [1] R.K. Zahn, J. Reinmüller, R. Beyer and V. Pondeljak, Age-correlated DNA damage in human muscle tissue. Mech. Ageing Dev., 41 (1987) 73-114.
2. [2] P. Alexander, The role of DNA lesions in the processes leading to ageing in mice. Symp. Soc. Exp. Biol., 21 (1967) 29-50.
3. [3] K.L. Yielding, A model for aging based on differential repair of somatic mutational damage. Perspect. Biol. Med., 17, (1974) 201-208.
4. [4] K.C. Smith, Chemical adducts in deoxyribonucleic acid: their importance to the genetic alteration theory of aging. Interdiscip. Top. Gerontol., 9 (1976) 16-24.
5. [5] H.V. Samis Jr., A concept of bilogical ageing: the role of compensatory processes. J. Theor. Biol., 13 (1966) 236-252.
6. [6] H.L. Gensler and H. Bernstein, DNA damage as the primary cause of ageing. Quart. Rev. Biol., 56 (1981) 279-303.
7. [7] R.R. Tice and R.B. Setlow, DNA repair and replication in aging organisms and cells. In C.E. Finch and E.L. Schneider (eds.), Handbook of the Biology of Aging, 2nd edn., Van Nostrand Reinhold, New York, 1985, pp. 173-224.
8. [8] E.P. Mullaart, P.H.M. Lohman, F. Berends and J. Vijg, DNA damage metabolism and aging. Mutat. Res., 237 (1990) 189-210.
9. [9] C. Bernstein and H. Bernstein, Aging, Sex, and DNA Repair, Academic Press, San Diego, CA, 1991.
10. [10] B.N. Ames and L.S. Gold, Endogenous mutagens and the causes of aging and cancer. Mutat. Res., 280 (1991) 3-16.
11. [11] G.E. Holmes, C. Bernstein and H. Bernstein, Oxidative and other DNA damages as the basis of aging: A review. Mutat. Res., 275 (1992) 305-315.
12. [12] H. Weirich-Schwaiger, H.G. Weirich, B. Gruber, M. Schweiger and M. Hirsch-Kauffmann, Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res., 316 (1994) 37-48.
13. [13] D.L. Stout and F.F. Becker, Fluorometric quantitation of single-stranded DNA: A method applicable to the technique of alkaline elution. Anal. Biochem., 127 (1982) 302-307.
14. [14] L. Hayflick, The limited in vitro lifetime of human diploid cellstrains. Exp. Cell Res., 37 (1965) 614.
15. [15] A.L. Muggleton-Harris and L. Hayflick, Cellular aging studies by the reconstruction of replicating cells from nuclei and cytoplasms isolated from normal human diploid cells. Exp. Cell Res., 103 (1976) 321.
16. [16] J.A. Bond, F.S. Wyllie and D. Wynford-Thomas, Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene, 9 (1994) 1885-1889.
17. [17] K.W. Kohn, L.C. Erickson, R.A.G. Ewig and C.A. Friedman, Fractionation of DNA from mammalian cells by alkaline elution. Biochemistry, 15 (1976) 4629-4643.
18. [18] K.W. Kohn, Principles and practice of DNA filter elution. Pharmac. Ther., 49 (1991) 55-77.
19. [19] P.T. Sharpe, Methods of cell separation. In R.H. Burdon and P.H. van Knippenberg (eds.), Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 18, Elsevier, Amsterdam, 1988, p. 260.
20. [20] S. Yamashiro and F. Matsumura, Mitosis-specific phosphorylation of caldesmon: possible molecular mechanism of cell rounding during mitosis. Bioessays, 13 (1991) 563-568.
21. [21] A.R. Wechezak, R.F. Viggers, D.E. Coan and L.R. Sauvage, Mitosis and cytokinesis in subconfluent endothelial cells exposed to increasing levels of shear stress. J. Cell. Physiol., 159 (1994) 83-91.
22. [22] Y. Higami, I. Shimokawa, T. Okimoto and T. Ikeda, DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats. Mutat. Res., 316 (1994) 59-67.
23. [23] D.E. Graham, The isolation of high molecular weight DNA from whole organisms or large tissue masses. Anal. Biochem., 85 (1978) 609-615.
24. [24] C.J. Koch and A.R. Giandomenico, The alakaline elution technique for measuring DNA single strand breaks: Increased reliability and sensitivity. Anal. Biochem., 220 (1994) 58-65.
25. [25] K.W. Kohn, R.A. Ewig, L.C. Erickson and L.A. Zwelling, Measurement of strand breaks and cross links by alkaline elution. In E.C. Friedberg and P.C. Hanawalt (eds.), DNA repair: A Laboratory Manual of Research Procedures, Marcel Dekker, New York, 1981, pp. 379-401.
26. [26] M.J. Peak and J.G. Peak, Convex curvatures of alkaline elution profiles of DNA from human cells irradiated with 405 nm UVA: Evidence for induction of slowly developing alkali-labile sites. Photochem. Photobiol., 50 (1989) 379-383.
27. [27] M.V.M. Lafleur, J. Wolhuis and H. Loman, Alkali-labile sites in biologically active DNA: Comparison of radiation induced potential breaks and apurinic sites. Int. J. Radiat. Biol., 39 (1981) 113-118.
28. [28] J.-M. Sequaris, P. Valenta and H.W. Nürnberg, A new electrochemical approach for the in vitro investigation of damage in native DNA by small gamma-radiation doses. Int. J. Radiat. Biol., 42 (1982) 407-415.
29. [29] D. Werner, W. Krauth and H.V. Hershey, Internucleotide protein linkers in Ehrlich ascites cell DNA. Biochim. Biophys. Acta, 608 (1980) 243-258.
30. [30] R.G. Cutler, Cross-linkage hypothesis of aging: DNA adducts in chromatin as a primary aging process. Aging, Carcinogenesis and Radiation Biology, Plenum, New York, 1976, pp. 443-456.
31. 2 in magnesium-insoluble regions of fractionated chinese hamster ovary cell chromatin. Cancer Res., 45 (1985) 5787-5794.
32. [32] T.M. Reid and L.A. Loeb, Tandem double CC-TT mutations are produced by reactive oxygen species. Proc. Natl. Acad. Sci. USA, 90 (1993) 3904-3907.
33. [33] S.J. Whitaker. DNA damage by drugs and radiation: What is important and how is it measured? Eur. J. Cancer, 28 (1992) 273-276.
34. [34] M. Nagao and T. Sugimura, Molecular biology of the carcinogen 4-nitroquinoline 1-oxide. Adv. Cancer Res., 23 (1976) 1331-1369.
35. [35] B.L. Strehler, Time, Cells, and Aging. Academic Press, New York, 1977.
36. [36] Th. Nikolaus and.K. Zahn, Alter und Altern. In R.F. Schmidt and G. Thews (eds.), Physiologie des Menschen, Springer, New York, 1995, pp. 708-719.