Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: Analysis with a novel reverse transcriptase-polymerase chain reaction assay

Biochemical Pharmacology

Volumn 60, Issue 10, 2000, Pages 1509-1518

  A Chr 't Hoen, Peter ^a   Commandeur, Jan N M ^a   Vermeulen, Nico P E ^a   Van Berkel, Theo J C ^a   Bijsterbosch, Martin K ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Cytochrome P450; Drug metabolism; Gene expression; Primary rat hepatocyte; RT PCR; Testosterone hydroxylation

Indexed keywords

CYTOCHROME P450 3A1; CYTOCHROME P450 3A18; CYTOCHROME P450 3A2; CYTOCHROME P450 3A9; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ISOTOPE LABELING; LIVER CELL CULTURE; MALE; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROID HYDROXYLATION;

ANIMAL; ANTI-INFLAMMATORY AGENTS, STEROIDAL; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; IN VITRO; LIVER; MALE; MIXED FUNCTION OXYGENASES; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTOSTERONE;

EID: 0034670169     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00454-8     Document Type: Article

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