Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay

Mycopathologia

Volumn 148, Issue 2, 2000, Pages 97-102

  Lewis, C W ^a   Smith, J E ^a   Anderson, J G ^a   Freshney, R I ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cell culture; Food borne mycotoxins; Human cytochrome P450s; Metabolic activity; MTT assay; Transformed human cell lines

Indexed keywords

EID: 0033285974     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007130923558     Document Type: Article

References (27)

1. Mycotoxins, general view, chemistry and structure
2. Mycotoxins: Food contamination, mechanism, carcinogenic potential and preventive measures
3. Mycotoxins in review
4. Diet/toxin interactions
5. Health-related aspects of the genus Aspergillus
6. In vitro alternatives to toxicity testing in animals
7. The use of tissue culture for the detection of mycotoxins
8. An optimised MTT bioassay for determination of fumonisins in turkey lymphocytes
9. Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay
10. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with plasmid containing the SV40
11. Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2
12. Toxicity and metabolism of ochratoxin A
13. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukaemia cells
14. A new formazan amplified clonogenic assay for cytoxicity testing
15. Cytotoxicity evaluation of mycotoxins by an MTT bioassay
16. Toxicity evaluation of the mycotoxins, citrinin and ochratoxin A, Using several animal cell lines
17. 1 and comparison to CYP 1A2 and CYP 2A3
18. 1
19. 1 metabolism in hepatitis virus transgenic mice
20. Aflatoxin, its metabolism and carcinogenesis - A historical review
21. 1, using metabolic inducers, inhibitors and antibodies
22. Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation
23. Regioselective biotransformation of midazolam by members of the human CYP3A subfamily
24. CYP3A gene expression in human gut epithelium
25. The role of nutrients in detoxification mechanisms