메뉴 건너뛰기




Volumn 13, Issue 4-5, 1999, Pages 625-632

Use of transgenic cell lines in mechanistic studies of drug metabolism

Author keywords

Cytochrome P450; Recombinant enzyme

Indexed keywords

CYTOCHROME P450; DRUG; RECOMBINANT ENZYME;

EID: 0032839439     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00035-1     Document Type: Conference Paper
Times cited : (7)

References (31)
  • 1
    • 0028916159 scopus 로고
    • Particular ability of cytochrome P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs
    • Bensoussan C., Delaforge M., Mansuy D. Particular ability of cytochrome P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs. Biochemical Pharmacology. 49:1995;591-602.
    • (1995) Biochemical Pharmacology , vol.49 , pp. 591-602
    • Bensoussan, C.1    Delaforge, M.2    Mansuy, D.3
  • 2
    • 0026552617 scopus 로고
    • Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction
    • Bergstrom R.F., Peyton A.L., Lemberger L. Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction. Clinical Pharmacology and Therapy. 51:1992;239-248.
    • (1992) Clinical Pharmacology and Therapy , vol.51 , pp. 239-248
    • Bergstrom, R.F.1    Peyton, A.L.2    Lemberger, L.3
  • 7
    • 0027491376 scopus 로고
    • Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450
    • Crespi C.L., Langenbach R., Penman B.W. Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450. Toxicology. 82:1993;89-104.
    • (1993) Toxicology , vol.82 , pp. 89-104
    • Crespi, C.L.1    Langenbach, R.2    Penman, B.W.3
  • 8
    • 0031570357 scopus 로고    scopus 로고
    • Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450
    • Crespi C.L., Miller V.P., Penman B.W. Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450. Analytical Biochemistry. 248:1997;188-190.
    • (1997) Analytical Biochemistry , vol.248 , pp. 188-190
    • Crespi, C.L.1    Miller, V.P.2    Penman, B.W.3
  • 9
    • 0030627339 scopus 로고    scopus 로고
    • Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions
    • Crespi C.L., Penman B.W. Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions. Advances in Pharmacology. 43:1997;171-188.
    • (1997) Advances in Pharmacology , vol.43 , pp. 171-188
    • Crespi, C.L.1    Penman, B.W.2
  • 10
    • 0026346377 scopus 로고
    • Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds
    • Franklin M.R. Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds. Methods in Enzymology. 206:1991;559-573.
    • (1991) Methods in Enzymology , vol.206 , pp. 559-573
    • Franklin, M.R.1
  • 11
    • 0017717638 scopus 로고
    • Inhibition of mixed function oxidations by substrates forming reduced cytochrome P450 metabolic-intermediate complexes
    • Franklin M.R. Inhibition of mixed function oxidations by substrates forming reduced cytochrome P450 metabolic-intermediate complexes. Pharmacology and Therapeutics. 2:1977;227-245.
    • (1977) Pharmacology and Therapeutics , vol.2 , pp. 227-245
    • Franklin, M.R.1
  • 12
    • 0026324032 scopus 로고
    • Expression of mammalian cytochrome P450 using vaccinia virus
    • Gonzalez F.J., Aoyama T., Gelboin H.V. Expression of mammalian cytochrome P450 using vaccinia virus. Methods in Enzymology. 206:1991;85-92.
    • (1991) Methods in Enzymology , vol.206 , pp. 85-92
    • Gonzalez, F.J.1    Aoyama, T.2    Gelboin, H.V.3
  • 13
    • 0027163866 scopus 로고
    • Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio
    • Gram L.F., Brosen K. Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. British Journal of Clinical Pharmacology. 35:1993;649-652.
    • (1993) British Journal of Clinical Pharmacology , vol.35 , pp. 649-652
    • Gram, L.F.1    Brosen, K.2
  • 15
    • 0025184340 scopus 로고
    • Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene
    • Guengerich F.P. Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene. Chemical Research in Toxicology. 3:1990;363-371.
    • (1990) Chemical Research in Toxicology , vol.3 , pp. 363-371
    • Guengerich, F.P.1
  • 17
    • 0027468338 scopus 로고
    • Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10
    • Lopez Garcia M.P., Dansette P.M., Valadon P., Amar C., Beaune P.H., Guengerich F.P., Mansuy D. Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. European Journal of Biochemistry. 213:1993;223-232.
    • (1993) European Journal of Biochemistry , vol.213 , pp. 223-232
    • Lopez, G.M.P.1    Dansette, P.M.2    Valadon, P.3    Amar, C.4    Beaune, P.H.5    Guengerich, F.P.6    Mansuy, D.7
  • 18
    • 0018237989 scopus 로고
    • Selective effects of reversed phase column packings in HPLC of steroids
    • Nice E.C., O'Hare M.J. Selective effects of reversed phase column packings in HPLC of steroids. Journal of Chromatography. 166:1978;263-267.
    • (1978) Journal of Chromatography , vol.166 , pp. 263-267
    • Nice, E.C.1    O'Hare, M.J.2
  • 19
    • 0029908277 scopus 로고    scopus 로고
    • The importance of nonspecific binding in In vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations
    • Obach R.S. The importance of nonspecific binding in In vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations. Drug Metabolism and Disposition. 24:1996;1047-1049.
    • (1996) Drug Metabolism and Disposition , vol.24 , pp. 1047-1049
    • Obach, R.S.1
  • 20
    • 0031719374 scopus 로고    scopus 로고
    • Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective
    • Park B.K., Pirmohamed M., Kitteringham N.R. Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective. Chemical Research in Toxicology. 11:1998;969-988.
    • (1998) Chemical Research in Toxicology , vol.11 , pp. 969-988
    • Park, B.K.1    Pirmohamed, M.2    Kitteringham, N.R.3
  • 21
    • 0031025875 scopus 로고    scopus 로고
    • Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism
    • Preskorn S.H. Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism. Clinical Pharmacokinetics. 32:(Suppl. 1):1997;1-21.
    • (1997) Clinical Pharmacokinetics , vol.32 , Issue.1 SUPPL. , pp. 1-21
    • Preskorn, S.H.1
  • 23
    • 0031572185 scopus 로고    scopus 로고
    • A general strategy for the expression of recombinant human cytochrome P450 s in Escherichia coli using bacterial signal peptides: Expression of CYP3A4, CYP2A6, and CYP2E1
    • Pritchard M.P., Ossetian R., Li D.N., Henderson C.J., Burchell B., Wolf C.R., Friedberg T. A general strategy for the expression of recombinant human cytochrome P450 s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1. Archives of Biochemistry and Biophysics. 345:1997;342-354.
    • (1997) Archives of Biochemistry and Biophysics , vol.345 , pp. 342-354
    • Pritchard, M.P.1    Ossetian, R.2    Li, D.N.3    Henderson, C.J.4    Burchell, B.5    Wolf, C.R.6    Friedberg, T.7
  • 24
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F.P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapy. 270:1994;414-423.
    • (1994) Journal of Pharmacology and Experimental Therapy , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 25
    • 0027943901 scopus 로고
    • Direct characterization of the selectivity of furafylline as an inhibitor of human cytochromes P4501A1 and 1A2
    • Tassaneeyakul W., Birkett D.J., Veronese M.E., McManus M.E., Tukey R.H., Miners J.O. Direct characterization of the selectivity of furafylline as an inhibitor of human cytochromes P4501A1 and 1A2. Pharmacogenetics. 4:1994;281-284.
    • (1994) Pharmacogenetics , vol.4 , pp. 281-284
    • Tassaneeyakul, W.1    Birkett, D.J.2    Veronese, M.E.3    McManus, M.E.4    Tukey, R.H.5    Miners, J.O.6
  • 26
    • 0030574227 scopus 로고    scopus 로고
    • Pharmacologic and therapeutic differences among calcium channel antagonists: Profile of mibefradil, a calcium antagonist
    • Triggle D.J. Pharmacologic and therapeutic differences among calcium channel antagonists: profile of mibefradil, a calcium antagonist. American Journal of Cardiology. 78:1996;7-12.
    • (1996) American Journal of Cardiology , vol.78 , pp. 7-12
    • Triggle, D.J.1
  • 27
    • 0026677681 scopus 로고
    • The rational selection of drug interaction studies: Implications of recent advances in drug metabolism
    • Tucker G.T. The rational selection of drug interaction studies: Implications of recent advances in drug metabolism. International Journal of Clinical Pharmacology, Therapeutics and Toxicology. 30:1992;550-553.
    • (1992) International Journal of Clinical Pharmacology, Therapeutics and Toxicology , vol.30 , pp. 550-553
    • Tucker, G.T.1
  • 28
    • 0027361819 scopus 로고
    • In vitro hepatic biotransformation of moclobemide (Ro 11-1163) in man and rat
    • Valles B., Coassolo P., De Sousa G., Aubert C., Rahmani R. In vitro hepatic biotransformation of moclobemide (Ro 11-1163) in man and rat. Xenobiotica. 23:1993;1101-1111.
    • (1993) Xenobiotica , vol.23 , pp. 1101-1111
    • Valles, B.1    Coassolo, P.2    De Sousa, G.3    Aubert, C.4    Rahmani, R.5
  • 29
    • 0016174577 scopus 로고
    • Preparation and properties of partially purified cytochrome P450 and reduced nicotinamide adenine dinucleotide phosphate cytochrome P450 reductase from rabbit liver microsomes
    • van der Hoeven T.A., Coon M. Preparation and properties of partially purified cytochrome P450 and reduced nicotinamide adenine dinucleotide phosphate cytochrome P450 reductase from rabbit liver microsomes. Journal of Biological Chemistry. 249:1974;6302-6310.
    • (1974) Journal of Biological Chemistry , vol.249 , pp. 6302-6310
    • Van Der Hoeven, T.A.1    Coon, M.2
  • 30
    • 0028194864 scopus 로고
    • Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: A model system to predict drug interactions in vivo
    • Von Moltke L.L., Greenblatt D.J., Cotreau-Bibbo M.M., Duan S.X., Harmatz J.S., Shader R.I. Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo. Journal of Pharmacology and Experimental Therapeutics. 268:1994;1278-1283.
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.268 , pp. 1278-1283
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Cotreau-Bibbo, M.M.3    Duan, S.X.4    Harmatz, J.S.5    Shader, R.I.6
  • 31
    • 0029130840 scopus 로고
    • Macrolide antibacterials. Drug interactions of clinical significance
    • von Rosensteil N.A., Adam D. Macrolide antibacterials. Drug interactions of clinical significance. Drug Safety. 13:1995;105-122.
    • (1995) Drug Safety , vol.13 , pp. 105-122
    • Von Rosensteil, N.A.1    Adam, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.