In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates

Toxicology

Volumn 154, Issue 1-3, 2000, Pages 31-44

  Koebe, H G ^a   Deglmann, C J ^a   Metzger, R ^b   Hoerrlein, S ^b   Schildberg, F W ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Cell Control Biomedical Laboratories   (Germany)

Author keywords

Bioreactor; Cyclophosphamide; Hepatocytes; In vitro; Microphysiometer; Perfusion system; Toxicity testing

Indexed keywords

4 HYDROXYCYCLOPHOSPHAMIDE; COLLAGEN; CYCLOPHOSPHAMIDE; CYTOCHROME P450; CYTOSTATIC AGENT;

ACIDIFICATION; ADOLESCENT; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BIOREACTOR; CELL PH; CELL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CYTOTOXICITY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; SUPERNATANT; SWINE; TOXICITY TESTING; TUMOR CELL LINE;

ALBUMINS; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BIOREACTORS; CYCLOPHOSPHAMIDE; DNA; DRUG EVALUATION, PRECLINICAL; FEMALE; FLUOROMETRY; HEPATOCYTES; HYDROGEN-ION CONCENTRATION; L-LACTATE DEHYDROGENASE; MALE; MUTAGENS; OSMOLAR CONCENTRATION; PERFUSION; SWINE; TOXICITY TESTS; TUMOR CELLS, CULTURED; UMBELLIFERONES;

ANIMALIA; SUS SCROFA;

EID: 0034706904     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00270-5     Document Type: Article

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