Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line Hep G2

Drug Metabolism and Disposition

Volumn 28, Issue 9, 2000, Pages 1077-1082

  Walle, Thomas ^a   Otake, Yoko ^a   Galijatovic, Alema ^a   Ritter, Joseph K ^b   Walle, U Kristina ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CHRYSIN; ETHINYLESTRADIOL; FLAVONOID; GLUCURONOSYLTRANSFERASE; MESSENGER RNA; ORAL CONTRACEPTIVE AGENT;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME KINETICS; ENZYME SUBSTRATE; GLUCURONIDATION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL;

BILIRUBIN; BLOTTING, NORTHERN; BLOTTING, WESTERN; FLAVONOIDS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; MICROSOMES, LIVER; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0033840250     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Biliary excretion of metabolites of baicalin and baicalein in rats
2. Glucuronidation in the Caco-2 human intestinal cell line: Induction of UDP-glucuronosyltransferase 1*6
3. Human cell lines in pharmaco-toxicology: An introduction to a panel discussion
4. Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases
5. In vivo and in vitro glucuronidation of the flavonoid diosmetin in rats
6. UDP-Glucuronosyltransferases
7. Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver
8. Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8
9. Hereditary jaundice and disorders of bilirubin metabolism
10. Chemopreventive activity of oltipraz
11. Glucuronidation in humans: Pharmacogenetic and developmental aspects
12. Substrate specificities of two stably expressed human liver UDP-glucoronosyltransferases of the UGT1 gene family
13. Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol
14. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells
15. Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells
16. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
17. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates
18. Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol
19. Effects of watercress consumption on urinary metabolites of nicotine in smokers
20. Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver
21. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study
22. The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1
23. 85): A UDP-glucuronosyltransferase encoded by a polymorphic gene
24. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
25. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
26. Drug glucuronidation in humans
27. Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells
28. Structural and functional studies of UDP-glucuronosyltransferases
29. Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences
30. Identification of tissues responsible for the conjugative metabolism of liquiritigenin in rats: An analysis based on metabolite kinetics
31. Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids
32. UDP-Glucuronosyltransferase activity in human liver and colon
33. Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells
34. Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids - Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo
35. Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone