Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase

Pharmaceutical Research

Volumn 16, Issue 9, 1999, Pages 1352-1359

  Hu, Ming ^a   Li, Yiqi ^a   Davitt, Christine M ^a   Huang, Shiew Mei ^b,c   Thummel, Kenneth ^d   Penman, Bruce W ^e   Crespi, Charles L ^e  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b DUPONT COMPANY   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e Gentest Corporation   (United States)

Author keywords

Caco 2 cells; CYP3A4; Oxidoreductase; Transfection; Transport characteristics

Indexed keywords

CEFALEXIN; CYTOCHROME; LINOPIRDINE; MANNITOL; NIFEDIPINE; OXIDOREDUCTASE; PROPRANOLOL; TESTOSTERONE;

ARTICLE; CELL METABOLISM; CELL TRANSPORT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG TRANSPORT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROSCOPY; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ANTICOAGULANTS; ANTINEOPLASTIC AGENTS, HORMONAL; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; CARCINOGENS; CELL DIVISION; CYTOCHROME P-450 ENZYME SYSTEM; DIURETICS, OSMOTIC; GABA MODULATORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; HUMANS; INDOLES; MAMMARY TUMOR VIRUS, MOUSE; MANNITOL; MICROSCOPY, ELECTRON; MICROSOMES; MIDAZOLAM; MIXED FUNCTION OXYGENASES; NIFEDIPINE; OXIDOREDUCTASES; PROPRANOLOL; PYRIDINES; SYMPATHOLYTICS; TESTOSTERONE; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION; TRITIUM; WARFARIN;

EID: 0032885491     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018986605929     Document Type: Article

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