Endoproteolysis of β-secretase (β-site amyloid precursor protein-cleaving enzyme) within its catalytic domain: A potential mechanism for regulation

Journal of Biological Chemistry

Volumn 278, Issue 19, 2003, Pages 17141-17149

  Huse, Jason T ^a   Byant, Damani ^b   Yang, Yaxiong ^b   Pijak, Donald S ^a   D'Souza, Ian ^b   Lah, James J ^c   Lee, Virginia M Y ^a   Doms, Robert W ^a   Cook, David G ^b,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOLOGICAL MEMBRANES; CATALYSIS; TISSUE CULTURE;

PROTEOLYSIS;

ENZYMES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; ASPARTIC PROTEINASE;

ALZHEIMER DISEASE; ARTICLE; BRAIN DISEASE; CATALYSIS; CELL CULTURE; CELL LYSATE; DEGENERATIVE DISEASE; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER; MUSCLE; NEUROLOGIC DISEASE; PANCREAS; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; CELL LINE; ENZYME ACTIVE SITE; HAMSTER; HYDROLYSIS; METABOLISM;

ANIMALIA;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CATALYTIC DOMAIN; CELL LINE; CRICETINAE; HUMANS; HYDROLYSIS;

EID: 0037931840     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M213303200     Document Type: Article

References (61)

1. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Price, D. L., and Sisodia, S. S. (1998) Annu. Rev. Neurosci. 21, 479-505
3. Selkoe, D. J. (1999) Nature 399, (suppl.) A23-A31
4. Chen, G., Chen, K. S., Knox, J., Inglis, J., Bernard, A., Martin, S. J., Justice, A., McConlogue, L., Games, D., Freedman, S. B., and Morris, R. G. (2000) Nature 408, 975-979
5. Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., Mount, H. T., Nixon, R. A., Mercken, M., Bergeron, C., Fraser, P. E., St. George-Hyslop, P., and Westaway, D. (2000) Nature 408, 979-982
6. Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M., and Arendash, G. W. (2000) Nature 408, 982-985
7. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., and Ward, P. J. (1990) Science 248, 1122-1124
8. Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., Smith, T. S., Simmons, D. L., Walsh, F. S., Dingwall, C., and Christie, G. (1999) Mol. Cell. Neurosci. 14, 419-427
9. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., Zhao, J., McConlogue, L., and John, V. (1999) Nature 402, 537-540
10. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jaronsinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J.-C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
11. Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heinrikson, R. L., and Gurney, M. E. (1999) Nature 402, 533-537
12. Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., and Tang, J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1456-1460
13. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
14. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Diehl, T. S., Moore, C. L., Tsai, J. Y., Rahmati, T., Xia, W., Selkoe, D. J., and Wolfe, M. S. (2000) Nat. Cell Biol. 2, 428-434
15. Kimberly, W. T., Xia, W., Rahmati, T., Wolfe, M. S., and Selkoe, D. J. (2000) J. Biol. Chem. 275, 3173-3178
16. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694
17. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himes, C. S., Hiebsch, R., Ruble, C., Nye, J. S., and Curtis, D. (2002) Dev. Cell 3, 85-97
18. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) J. Biol. Chem. 273, 27765-27767
19. Skovronsky, D. M., Moore, D. B., Milla, M. E., Doms, R. W., and Lee, V. M.-Y. (2000) J. Biol. Chem. 275, 2568-2575
20. De Strooper, B., Beullens, M., Contreras, B., Levesque, L., Craessaerts, K., Cordell, B., Moechars, D., Bollen, M., Fraser, P., St. George-Hyslop, P., and Van Leuven, F. (1997) J. Biol. Chem. 272, 3590-3598
21. Seeger, M., Nordstedt, C., Petanceska, S., Kovacs, D. M., Gouras, G. K., Hahne, S., Fraser, P., Levesque, L., Czernik, A. J., St. George-Hyslop, P., Sisodia, S. S., Thinakaran, G., Tanzi, R. E., Greengard, P., and Gandy, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5090-5094
22. Walter, J., Grunberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., St. George-Hyslop, P., Multhaup, G., Selkoe, D. J., and Haass, C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5349-5354
23. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
24. Kim, T.-W., Pettingell, W. H., Hallmark, O. G., Moir, R. D., Wasco, W., and Tanzi, R. E. (1997) J. Biol. Chem. 272, 11006-11010
25. Thinakaran, G., Harris, C. L., Ratovitski, T., Davenport, F., Slunt, H. H., Price, D. L., Borchelt, D. R., and Sisodia, S. S. (1997) J. Biol. Chem. 272, 28415-28422
26. Capell, A., Grunberg, J., Pesold, B., Diehlmann, A., Citron, M., Nixon, R., Beyreuther, K., Selkoe, D. J., and Haass, C. (1998) J. Biol. Chem. 273, 3205-3211
27. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D. M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St. George-Hyslop, P. H., and Fraser, P. E. (1998) J. Biol. Chem. 273, 16470-16475
28. Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G., and Haass, C. (2000) J. Biol. Chem. 275, 30849-30854
29. Haniu, M., Denis, P., Young, Y., Mendiaz, E. A., Fuller, J., Hui, J., Bennett, B. D., Kahn, S., Ross, S., Burgess, T., Katta, V., Rogers, G., Vassar, R., and Citron, M. (2000) J. Biol. Chem. 275, 21099-21106
30. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M.-Y., and Doms, R. W. (2000) J. Biol. Chem. 275, 33729-33737
31. Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J. C., Citron, M., and Vassar, R. (2000) J. Biol. Chem. 275, 37712-37717; Correction (2001) J. Biol. Chem. 276, 15561
32. Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J. C., Citron, M., and Vassar, R. (2000) J. Biol. Chem. 275, 37712-37717; Correction (2001) J. Biol. Chem. 276, 15561
33. Creemers, J. W., Dominguez, D. I., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, K., Annaert, W., and De Strooper, B. (2001) J. Biol. Chem. 276, 4211-4217
34. Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S. S., Checler, F., Cretien, M., and Seidah, N. G. (2001) J. Biol. Chem. 14, 10879-10887
35. Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G., and Haass, C. (2001) J. Biol. Chem. 276, 14634-14641
36. Huse, J. T., Liu, K., Pijak, D. S., Lee, V. M.-Y., and Doms, R. W. (2002) J. Biol. Chem. 277, 16278-16284
37. Bosshart, H., Humphrey, J., Deignan, E., Davidson, J., Drazba, J., Yuan, L., Oorschot, V., Peters, P. J., and Bonifacino, J. S. (1994) J. Cell Biol. 126, 1157-1172
38. Cook, D. G., Sung, J. C., Golde, T. E., Felsenstein, K. M., Wojczyk, B. S., Tanzi, R. E., Trojanowski, J. Q., Lee, V. M.-Y., and Doms, R. W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9223-9228
39. Chyung, A. S. C., Greenberg, B. D., Cook, D. G., Doms, R. W., and Lee, V. M.-Y. (1997) J. Cell Biol. 138, 671-680
40. Yaffe, D., and Saxel, O. (1977) Nature 270, 725-727
41. Hong, L., Koelsch, G., Lin, X., Wu, S., Terzyan, S., Ghosh, A., Zhang, X. C., and Tang, J. (2000) Science 290, 150-153
42. Lie, S. O., and Schofield, B. (1973) Biochem. Pharmacol. 22, 3109-3114
43. Krogstad, D. J., Schlesinger, P. H., and Gluzman, I. Y. (1985) J. Cell Biol. 101, 2302-2309
44. Drose, S., and Altendorf, K. (1997) J. Exp. Biol. 200, 1-8
45. Nelson, N. (1991) Trends Pharmacol. Sci. 12, 71-75
46. Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stockling, K. L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J., and Cerretti, D. P. (1997) Nature 385, 729-733
47. Moss, M. L., Jin, S.-L. C., Milla, M. E., Burkhart, W., Carter, H. L., Chen, W.-J., Clay, W. C., Didsbury, J. R., Hassler, D., Hoffman, C. R., Kost, T. A., Lambert, M. H., Leesnitzer, M. A., McCauley, P., McGeehan, G., Mitchell, J., Moyer, M., Pahel, G., Rocque, W., Overton, L. K., Schoenen, F., Seaton, T., Su, J.-L., Warner, J., D., W., and Becherer, J. D. (1997) Nature 385, 733-736
48. Nakayama, K. (1997) Biochem. J. 327, 625-635
49. Neurath, H. (1986) J. Cell. Biochem. 32, 35-49
50. Khan, A. R., and James, M. N. G. (1998) Protein Sci. 7, 815-836
51. Wolfsberg, T. G., Primakoff, P., Myles, D. G., and White, J. M. (1995) J. Cell Biol. 131, 275-278
52. Blobel, C. P. (1997) Cell 90, 589-592
53. Bennett, B. D., Babu-Khan, S., Loeloff, R., Louis, J.-C., Curran, E., Citron, M., and Vassar, R. (2000) J. Biol. Chem. 275, 20647-20651
54. Takahashi, K., Tanji, M., Yakabe, E., Hirasawa, A., Athauda, S. B. P., and Kageyama, T. (1995) Adv. Exp. Med. Biol. 362, 53-65
55. Yamamoto, K. (1995) Adv. Exp. Med. Biol. 362, 223-229
56. Ratovitski, T., Slunt, H. H., Thinakaran, G., Price, D. L., Sisodia, S. S., and Borchelt, D. R. (1997) J. Biol. Chem. 272, 24536-24541
57. Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P. M., Selkoe, D. J., Romig, H., Mendla, K., and Haass, C. (1998) J. Biol. Chem. 273, 32322-32331
58. Bodendorf, U., Fischer, F., Bodian, D., Multhaup, G., and Paganetti, P. (2001) J. Biol. Chem. 276, 12019-12023
59. Tanahashi, H., and Tabira, T. (2001) Neurosci. Lett. 307, 9-12
60. Ehehalt, R., Michel, B., De Pietri Tonelli, D., Zacchetti, D., Simons, K., and Keller, P. (2002) Biochem. Biophys. Res. Commun. 293, 30-37
61. Kitazume, S., Tachida, Y., Oka, R., Shirotani, K., Saido, T. C., and Hashimoto, Y. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 13554-13559