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Volumn 27, Issue 5-6, 2003, Pages 211-221

Therapy with thiopurine drugs - TDM and pharmacogenomics of TPMT;Tyherapie mit thiopurin-medikamenten - TDM und pharmakogenomik der TPMT

Author keywords

Genotype; Phenotype; Therapeutic drug monitoring; Thiopurine S methyltransferase; Thiopurines

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; AZATHIOPRINE; LIVER ENZYME; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE;

EID: 0037803482     PISSN: 03423026     EISSN: None     Source Type: Journal    
DOI: 10.1515/LabMed.2003.033     Document Type: Review
Times cited : (1)

References (98)
  • 1
    • 0024554561 scopus 로고
    • The purine path to chemotherapy
    • Elion GB. The purine path to chemotherapy. Science 1989;244:41-47.
    • (1989) Science , vol.244 , pp. 41-47
    • Elion, G.B.1
  • 2
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharmacol 1992;43:329-339.
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 329-339
    • Lennard, L.1
  • 3
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltransferase gene locus - Implications for clinical pharmacogenomics
    • McLeod HL, Siva C. The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics 2002;3:89-98.
    • (2002) Pharmacogenomics , vol.3 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 5
    • 0035423158 scopus 로고    scopus 로고
    • Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
    • Dervieux T, Blanco JG, Krynetski EY, Vanin EF, Roussel MF, Relling MV. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. Cancer Res 2001;61:5810-5816.
    • (2001) Cancer Res , vol.61 , pp. 5810-5816
    • Dervieux, T.1    Blanco, J.G.2    Krynetski, E.Y.3    Vanin, E.F.4    Roussel, M.F.5    Relling, M.V.6
  • 6
    • 0014501287 scopus 로고
    • Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides
    • Tay BS, Lilley RM, Murray AW, Atkinson MR. Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides. Biochem Pharmacol 1969;18:936-938.
    • (1969) Biochem Pharmacol , vol.18 , pp. 936-938
    • Tay, B.S.1    Lilley, R.M.2    Murray, A.W.3    Atkinson, M.R.4
  • 8
    • 0030699368 scopus 로고    scopus 로고
    • Optimisation of azathioprine immunosuppression after organ transplantation by pharmacological measurements
    • Bergan S. Optimisation of azathioprine immunosuppression after organ transplantation by pharmacological measurements. BioDrugs 1997;8:446-456.
    • (1997) BioDrugs , vol.8 , pp. 446-456
    • Bergan, S.1
  • 9
    • 0031663491 scopus 로고    scopus 로고
    • Clinical implications of thiopurine methyltransferase - Optimization of drug dosage and potential drug interactions
    • Lennard L. Clinical implications of thiopurine methyltransferase - optimization of drug dosage and potential drug interactions. Ther Drug Monit 1998;20:527-531.
    • (1998) Ther Drug Monit , vol.20 , pp. 527-531
    • Lennard, L.1
  • 10
    • 0033028272 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of antimetabolic cytotoxic drugs
    • Lennard L. Therapeutic drug monitoring of antimetabolic cytotoxic drugs. Br J Clin Pharmacol 1999;47:131-143.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 131-143
    • Lennard, L.1
  • 11
    • 0034765504 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in the treatment of inflammatory bowel disease
    • Schwab M, Klotz U. Pharmacokinetic considerations in the treatment of inflammatory bowel disease. Clin Pharmacokinet 2001;40:723-751.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 723-751
    • Schwab, M.1    Klotz, U.2
  • 12
    • 0021028642 scopus 로고
    • Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopurine and allopurinol
    • Zimm S, Collins JM, O'Neill D, Chabner BA, Poplack DG. Inhibition of first-pass metabolism in cancer chemotherapy: interaction of 6-mercaptopurine and allopurinol. Clin Pharmacol Ther 1983;34:810-817.
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 810-817
    • Zimm, S.1    Collins, J.M.2    O'Neill, D.3    Chabner, B.A.4    Poplack, D.G.5
  • 13
    • 0029953165 scopus 로고    scopus 로고
    • Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine?
    • Schutz E, Gummert J, Mohr FW, Armstrong VW, Oellerich M. Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine? Ther Drug Monit 1996;18:228-233.
    • (1996) Ther Drug Monit , vol.18 , pp. 228-233
    • Schutz, E.1    Gummert, J.2    Mohr, F.W.3    Armstrong, V.W.4    Oellerich, M.5
  • 14
    • 0344286478 scopus 로고    scopus 로고
    • Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine
    • Chrzanowska M, Krzymanski M. Determination of 6-thioguanine and 6-methylmercaptopurine metabolites in renal transplantation recipients and patients with glomerulonephritis treated with azathioprine. Ther Drug Monit 1999;21:231-237.
    • (1999) Ther Drug Monit , vol.21 , pp. 231-237
    • Chrzanowska, M.1    Krzymanski, M.2
  • 15
    • 0022361042 scopus 로고
    • Cellular pharmacokinetics of mercaptopurine in human neoplastic cells and cell lines
    • Zimm S, Johnson GE, Chabner BA, Poplack DG. Cellular pharmacokinetics of mercaptopurine in human neoplastic cells and cell lines. Cancer Res 1985;45:4156-4161.
    • (1985) Cancer Res , vol.45 , pp. 4156-4161
    • Zimm, S.1    Johnson, G.E.2    Chabner, B.A.3    Poplack, D.G.4
  • 16
    • 0035056404 scopus 로고    scopus 로고
    • Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase
    • Weinshilboum R. Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase. Drug Metab Dispos 2001;29:601-605.
    • (2001) Drug Metab Dispos , vol.29 , pp. 601-605
    • Weinshilboum, R.1
  • 17
    • 0035871560 scopus 로고    scopus 로고
    • Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
    • Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R, et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol 2001;19:2293-2301.
    • (2001) J Clin Oncol , vol.19 , pp. 2293-2301
    • Evans, W.E.1    Hon, Y.Y.2    Bomgaars, L.3    Coutre, S.4    Holdsworth, M.5    Janco, R.6
  • 19
    • 0034780344 scopus 로고    scopus 로고
    • Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide
    • Lowry PW, Franklin CL, Weaver AL, Szumlanski CL, Mays DC, Loftus EV, et al. Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide. Gut 2001;49:656-664.
    • (2001) Gut , vol.49 , pp. 656-664
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3    Szumlanski, C.L.4    Mays, D.C.5    Loftus, E.V.6
  • 20
    • 0036161781 scopus 로고    scopus 로고
    • Interaction between azathioprine and aminosalicylates: An in vivo study in patients with Crohn's disease
    • Dewit O, Vanheuverzwyn R, Desager JP, Horsmans Y. Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease. Aliment Pharmacol Ther 2002;16:79-85.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 79-85
    • Dewit, O.1    Vanheuverzwyn, R.2    Desager, J.P.3    Horsmans, Y.4
  • 21
    • 0027410849 scopus 로고
    • Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population
    • Klemetsdal B, Straume B, Wist E, Aarbakke J. Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population. Eur J Clin Pharmacol 1993;44:147-152.
    • (1993) Eur J Clin Pharmacol , vol.44 , pp. 147-152
    • Klemetsdal, B.1    Straume, B.2    Wist, E.3    Aarbakke, J.4
  • 22
    • 0030027378 scopus 로고    scopus 로고
    • Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide
    • Lysaa RA, Giverhaug T, Wold HL, Aarbakke J. Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol 1996;49:393-396.
    • (1996) Eur J Clin Pharmacol , vol.49 , pp. 393-396
    • Lysaa, R.A.1    Giverhaug, T.2    Wold, H.L.3    Aarbakke, J.4
  • 23
    • 0035031348 scopus 로고    scopus 로고
    • Human thiopurine S-methyltransferase activity in uremia and after renal transplantation
    • Weyer N, Kroplin T, Fricke L, Iven H. Human thiopurine S-methyltransferase activity in uremia and after renal transplantation. Eur J Clin Pharmacol 2001;57:129-136.
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 129-136
    • Weyer, N.1    Kroplin, T.2    Fricke, L.3    Iven, H.4
  • 24
    • 0018939350 scopus 로고
    • Thiol S-methylation in uremia: Erythrocyte enzyme activities and plasma inhibitors
    • Pazmino PA, Sladek SL, Weinshilboum RM. Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors. Clin Pharmacol Ther 1980;28:356-367.
    • (1980) Clin Pharmacol Ther , vol.28 , pp. 356-367
    • Pazmino, P.A.1    Sladek, S.L.2    Weinshilboum, R.M.3
  • 25
    • 0029842160 scopus 로고    scopus 로고
    • Quantitation of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy
    • Cuffari C, Seidman EG, Latour S, Theoret Y. Quantitation of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy. Can J Physiol Pharmacol 1996;74:580-585.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 580-585
    • Cuffari, C.1    Seidman, E.G.2    Latour, S.3    Theoret, Y.4
  • 26
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990;336:225-229.
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 27
    • 0028269944 scopus 로고
    • Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia
    • Lilleyman JS, Lennard L. Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia. Lancet 1994;343:1188-1190.
    • (1994) Lancet , vol.343 , pp. 1188-1190
    • Lilleyman, J.S.1    Lennard, L.2
  • 28
    • 0029794073 scopus 로고    scopus 로고
    • 6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity
    • Cuffari C, Theoret Y, Latour S, Seidman G. 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut 1996;39:401-406.
    • (1996) Gut , vol.39 , pp. 401-406
    • Cuffari, C.1    Theoret, Y.2    Latour, S.3    Seidman, G.4
  • 29
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Theoret Y, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000;118:705-713.
    • (2000) Gastroenterology , vol.118 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3    Targan, S.R.4    Sinnett, D.5    Theoret, Y.6
  • 30
    • 0035037706 scopus 로고    scopus 로고
    • Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease
    • Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease. Gut 2001;48:642-646.
    • (2001) Gut , vol.48 , pp. 642-646
    • Cuffari, C.1    Hunt, S.2    Bayless, T.3
  • 31
    • 0035113430 scopus 로고    scopus 로고
    • New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine
    • Armstrong VW, Oellerich M. New developments in the immunosuppressive drug monitoring of cyclosporine, tacrolimus, and azathioprine. Clin Biochem 2001;34:9-16.
    • (2001) Clin Biochem , vol.34 , pp. 9-16
    • Armstrong, V.W.1    Oellerich, M.2
  • 32
    • 0037517617 scopus 로고    scopus 로고
    • Pharmaka (drug monitoring)
    • Thomas L (ed.). Frankfurt/Main, TH-Books Verlagsgesellschaft
    • Oellerich M. Pharmaka (Drug Monitoring). In: Thomas L (ed.) Labor und Diagnose, 5. erweiterte Aufl. Frankfurt/Main, TH-Books Verlagsgesellschaft, 2000, pp 1170-1183.
    • (2000) Labor und Diagnose, 5. Erweiterte Aufl. , pp. 1170-1183
    • Oellerich, M.1
  • 33
    • 0032529469 scopus 로고    scopus 로고
    • Monitored high-dose azathioprine treatment reduces acute rejection episodes after renal transplantation
    • Bergan S, Rugstad HE, Bentdal O, Sodal G, Hartmann A, Leivestad T, et al. Monitored high-dose azathioprine treatment reduces acute rejection episodes after renal transplantation. Transplantation 1998;66:334-339.
    • (1998) Transplantation , vol.66 , pp. 334-339
    • Bergan, S.1    Rugstad, H.E.2    Bentdal, O.3    Sodal, G.4    Hartmann, A.5    Leivestad, T.6
  • 34
    • 0032801395 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine
    • Dervieux T, Medard Y, Baudouin V, Maisin A, Zhang D, Broly F, et al. Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine. Br J Clin Pharmacol 1999;48:793-800.
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 793-800
    • Dervieux, T.1    Medard, Y.2    Baudouin, V.3    Maisin, A.4    Zhang, D.5    Broly, F.6
  • 35
    • 0035166331 scopus 로고    scopus 로고
    • Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine
    • Dervieux T, Medard Y, Verpillat P, Guigonis V, Duval M, Lescoeur B, et al. Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine. Leukemia 2001;15:1706-1712.
    • (2001) Leukemia , vol.15 , pp. 1706-1712
    • Dervieux, T.1    Medard, Y.2    Verpillat, P.3    Guigonis, V.4    Duval, M.5    Lescoeur, B.6
  • 36
    • 0032767951 scopus 로고    scopus 로고
    • Metabolites of mercaptopurine in red blood cells: A relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia
    • Chrzanowska M, Kolecki P, Duczmal-Cichocka B, Fiet J. Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia. Eur J Pharm Sci 1999;8:329-334.
    • (1999) Eur J Pharm Sci , vol.8 , pp. 329-334
    • Chrzanowska, M.1    Kolecki, P.2    Duczmal-Cichocka, B.3    Fiet, J.4
  • 37
    • 0028130337 scopus 로고
    • Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes
    • Bergan S, Rugstad HE, Bentdal O, Stokke O. Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes. Transplantation 1994;58:803-808.
    • (1994) Transplantation , vol.58 , pp. 803-808
    • Bergan, S.1    Rugstad, H.E.2    Bentdal, O.3    Stokke, O.4
  • 38
    • 0036304389 scopus 로고    scopus 로고
    • Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia
    • Lancaster DL, Patel N, Lennard L, Lilleyman JS. Leucocyte versus erythrocyte thioguanine nucleotide concentrations in children taking thiopurines for acute lymphoblastic leukaemia. Cancer Chemother Pharmacol 2002;50:33-36.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 33-36
    • Lancaster, D.L.1    Patel, N.2    Lennard, L.3    Lilleyman, J.S.4
  • 39
    • 0036202803 scopus 로고    scopus 로고
    • 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    • Dubinsky MC, Yang H, Hassard PV, Seidman EG, Kam LY, Abreu MT, et al. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology 2002;122:904-915.
    • (2002) Gastroenterology , vol.122 , pp. 904-915
    • Dubinsky, M.C.1    Yang, H.2    Hassard, P.V.3    Seidman, E.G.4    Kam, L.Y.5    Abreu, M.T.6
  • 40
    • 0034891450 scopus 로고    scopus 로고
    • An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy
    • Dubinsky MC, Hassard PV, Seidman EG, Kam LY, Abreu MT, Targan SR, et al. An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy. Inflamm Bowel Dis 2001;7:181-189.
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 181-189
    • Dubinsky, M.C.1    Hassard, P.V.2    Seidman, E.G.3    Kam, L.Y.4    Abreu, M.T.5    Targan, S.R.6
  • 41
    • 0030050184 scopus 로고    scopus 로고
    • Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: Pharmacokinetic characteristics
    • Berkovitch M, Matsui D, Zipursky A, Blanchette VS, Verjee Z, Giesbrecht E, et al. Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: pharmacokinetic characteristics. Med Pediatr Oncol 1996;26:85-89.
    • (1996) Med Pediatr Oncol , vol.26 , pp. 85-89
    • Berkovitch, M.1    Matsui, D.2    Zipursky, A.3    Blanchette, V.S.4    Verjee, Z.5    Giesbrecht, E.6
  • 42
    • 0033828949 scopus 로고    scopus 로고
    • Genetic polymorphism of thiopurine S-methyltransferase: Molecular mechanisms and clinical importance
    • Krynetski EY, Evans WE. Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance. Pharmacology 2000;61:136-146.
    • (2000) Pharmacology , vol.61 , pp. 136-146
    • Krynetski, E.Y.1    Evans, W.E.2
  • 44
    • 0028044714 scopus 로고
    • Thiopurine methyltransferase activity in American white subjects and black subjects
    • McLeod HL, Lin JS, Scott EP, Pui CH, Evans WE. Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharmacol Ther 1994;55:15-20.
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 15-20
    • McLeod, H.L.1    Lin, J.S.2    Scott, E.P.3    Pui, C.H.4    Evans, W.E.5
  • 45
    • 0027372372 scopus 로고
    • Gender difference in red blood cell thiopurine methyltransferase activity
    • Klemetsdal B, Wist E, Aarbakke J. Gender difference in red blood cell thiopurine methyltransferase activity. Scand J Clin Lab Invest 1993;53:747-749.
    • (1993) Scand J Clin Lab Invest , vol.53 , pp. 747-749
    • Klemetsdal, B.1    Wist, E.2    Aarbakke, J.3
  • 46
    • 0028826952 scopus 로고
    • Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults
    • McLeod HL, Krynetski EY, Wilimas JA, Evans WE. Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults. Pharmacogenetics 1995;5:281-286.
    • (1995) Pharmacogenetics , vol.5 , pp. 281-286
    • McLeod, H.L.1    Krynetski, E.Y.2    Wilimas, J.A.3    Evans, W.E.4
  • 47
    • 0028842558 scopus 로고
    • Is there a gender difference in red blood cell thiopurine methyltransferase activity in healthy children?
    • Klemetsdal B, Flaegstad T, Aarbakke J. Is there a gender difference in red blood cell thiopurine methyltransferase activity in healthy children? Med Pediatr Oncol 1995;25:445-449.
    • (1995) Med Pediatr Oncol , vol.25 , pp. 445-449
    • Klemetsdal, B.1    Flaegstad, T.2    Aarbakke, J.3
  • 48
    • 0025790142 scopus 로고
    • Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population
    • Tinel M, Berson A, Pessayre D, Letteron P, Cattoni MP, Horsmans Y, et al. Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population. Br J Clin Pharmacol 1991;32:729-734.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 729-734
    • Tinel, M.1    Berson, A.2    Pessayre, D.3    Letteron, P.4    Cattoni, M.P.5    Horsmans, Y.6
  • 50
    • 0030871031 scopus 로고    scopus 로고
    • Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis
    • Leipold G, Schutz E, Haas JP, Oellerich M. Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. Arthritis Rheum 1997;40:1896-1898.
    • (1997) Arthritis Rheum , vol.40 , pp. 1896-1898
    • Leipold, G.1    Schutz, E.2    Haas, J.P.3    Oellerich, M.4
  • 51
    • 0027401302 scopus 로고
    • Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
    • Schütz E, Gummert J, Mohr F, Oellerich M. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993;341:436.
    • (1993) Lancet , vol.341 , pp. 436
    • Schütz, E.1    Gummert, J.2    Mohr, F.3    Oellerich, M.4
  • 52
    • 0027285234 scopus 로고
    • Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
    • McLeod HL, Miller DR, Evans WE. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993;341:1151.
    • (1993) Lancet , vol.341 , pp. 1151
    • McLeod, H.L.1    Miller, D.R.2    Evans, W.E.3
  • 53
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
    • Evans WE, Homer M, Chu YQ, Kalwinsky D, Roberts WM. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr 1991;119:985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Homer, M.2    Chu, Y.Q.3    Kalwinsky, D.4    Roberts, W.M.5
  • 54
    • 0032732591 scopus 로고    scopus 로고
    • Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine
    • Naughton MA, Battaglia E, O'Brien S, Walport MJ, Botto M. Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine. Rheumatology (Oxford) 1999;38:640-644.
    • (1999) Rheumatology (Oxford) , vol.38 , pp. 640-644
    • Naughton, M.A.1    Battaglia, E.2    O'Brien, S.3    Walport, M.J.4    Botto, M.5
  • 55
    • 0034093057 scopus 로고    scopus 로고
    • Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
    • Colombel JF, Ferrari N, Debuysere H, Marteau P, Gendre JP, Bonaz B, et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000;118:1025-1030.
    • (2000) Gastroenterology , vol.118 , pp. 1025-1030
    • Colombel, J.F.1    Ferrari, N.2    Debuysere, H.3    Marteau, P.4    Gendre, J.P.5    Bonaz, B.6
  • 56
    • 0027298873 scopus 로고
    • Human thiopurine methyltransferase: Molecular cloning and expression of T84 colon carcinoma cell cDNA
    • Honchel R, Aksoy IA, Szumlanski C, Wood TC, Otterness DM, Wieben ED, et al. Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA. Mol Pharmacol 1993;43:878-887.
    • (1993) Mol Pharmacol , vol.43 , pp. 878-887
    • Honchel, R.1    Aksoy, I.A.2    Szumlanski, C.3    Wood, T.C.4    Otterness, D.M.5    Wieben, E.D.6
  • 57
    • 0028913757 scopus 로고
    • Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1
    • Lee D, Szumlanski C, Houtman J, Honchel R, Rojas K, Overhauser J, et al. Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1. Drug Metab Dispos 1995;23:398-405.
    • (1995) Drug Metab Dispos , vol.23 , pp. 398-405
    • Lee, D.1    Szumlanski, C.2    Houtman, J.3    Honchel, R.4    Rojas, K.5    Overhauser, J.6
  • 58
    • 0030048791 scopus 로고    scopus 로고
    • Thiopurine methyltransferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism
    • Szumlanski C, Otterness D, Her C, Lee D, Brandriff B, Kelsell D, et al. Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism. DNA Cell Biol 1996;15:17-30.
    • (1996) DNA Cell Biol , vol.15 , pp. 17-30
    • Szumlanski, C.1    Otterness, D.2    Her, C.3    Lee, D.4    Brandriff, B.5    Kelsell, D.6
  • 59
    • 0031423467 scopus 로고    scopus 로고
    • Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PACl genomic library
    • Krynetski EY, Fessing MY, Yates CR, Sun D, Schuetz JD, Evans WE. Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PACl genomic library. Pharm Res 1997;14:1672-1678.
    • (1997) Pharm Res , vol.14 , pp. 1672-1678
    • Krynetski, E.Y.1    Fessing, M.Y.2    Yates, C.R.3    Sun, D.4    Schuetz, J.D.5    Evans, W.E.6
  • 60
    • 0033771907 scopus 로고    scopus 로고
    • Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene
    • Seki T, Tanaka T, Nakamura Y. Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene. J Hum Genet 2000;45:299-302.
    • (2000) J Hum Genet , vol.45 , pp. 299-302
    • Seki, T.1    Tanaka, T.2    Nakamura, Y.3
  • 63
    • 0036065978 scopus 로고    scopus 로고
    • Comprehensive assessment of thiopurine S-methyltransferase (TPMT) alleles in three ethnic populations
    • Evans WE. Comprehensive assessment of thiopurine S-methyltransferase (TPMT) alleles in three ethnic populations. J Pediatr Hematol Oncol 2002;24:335-336.
    • (2002) J Pediatr Hematol Oncol , vol.24 , pp. 335-336
    • Evans, W.E.1
  • 64
    • 0035755993 scopus 로고    scopus 로고
    • Recent advances in the pharmacogenomics of thiopurine methyltransferase
    • Coulthard SA, Hall AG. Recent advances in the pharmacogenomics of thiopurine methyltransferase. Pharmacogenomics J 2001;1:254-261.
    • (2001) Pharmacogenomics J , vol.1 , pp. 254-261
    • Coulthard, S.A.1    Hall, A.G.2
  • 65
    • 0005454374 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population
    • Spire-Vayron de la Moureyre, Debuysere H, Mastain B, Vinner E, Marez D, Lo Guidice JM, et al. Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population. Br J Pharmacol 1998;125:879-887.
    • (1998) Br J Pharmacol , vol.125 , pp. 879-887
    • Spire-Vayron de la Moureyre1    Debuysere, H.2    Mastain, B.3    Vinner, E.4    Marez, D.5    Lo Guidice, J.M.6
  • 66
    • 0032805244 scopus 로고    scopus 로고
    • Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter
    • Spire-Vayron de la Moureyre, Debuysere H, Fazio F, Sergent E, Bernard C, Sabbagh N, et al. Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter. Pharmacogenetics 1999;9:189-198.
    • (1999) Pharmacogenetics , vol.9 , pp. 189-198
    • Spire-Vayron de la Moureyre1    Debuysere, H.2    Fazio, F.3    Sergent, E.4    Bernard, C.5    Sabbagh, N.6
  • 67
    • 0033837392 scopus 로고    scopus 로고
    • Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis
    • Yan L, Zhang S, Eiff B, Szumlanski CL, Powers M, O'Brien JF, et al. Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis. Clin Pharmacol Ther 2000;68:210-219.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 210-219
    • Yan, L.1    Zhang, S.2    Eiff, B.3    Szumlanski, C.L.4    Powers, M.5    O'Brien, J.F.6
  • 68
    • 0034889535 scopus 로고    scopus 로고
    • Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity
    • Alves S, Amorim A, Ferreira F, Prata MJ. Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity. Clin Pharmacol Ther 2001;70:165-174.
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 165-174
    • Alves, S.1    Amorim, A.2    Ferreira, F.3    Prata, M.J.4
  • 69
    • 0037328448 scopus 로고    scopus 로고
    • Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians
    • Marinaki AM, Arenas M, Khan ZH, Lewis CM, Shobowale-Bakre EM, Escuredo E, et al. Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians. Pharmacogenetics 2003;13:97-105.
    • (2003) Pharmacogenetics , vol.13 , pp. 97-105
    • Marinaki, A.M.1    Arenas, M.2    Khan, Z.H.3    Lewis, C.M.4    Shobowale-Bakre, E.M.5    Escuredo, E.6
  • 70
    • 0023022265 scopus 로고
    • Historical background of 6-mercaptopurine
    • Elion GB. Historical background of 6-mercaptopurine. Toxicol Ind Health 1986;2:1-9.
    • (1986) Toxicol Ind Health , vol.2 , pp. 1-9
    • Elion, G.B.1
  • 71
    • 0028787817 scopus 로고
    • Determination of extracellular and intracellular thiopurines and methylthiopurines by high-performance liquid chromatography
    • Keuzenkamp-Jansen CW, De Abreu RA, Bokkerink JP, Trijbels JM. Determination of extracellular and intracellular thiopurines and methylthiopurines by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1995;672:53-61.
    • (1995) J Chromatogr B Biomed Appl , vol.672 , pp. 53-61
    • Keuzenkamp-Jansen, C.W.1    De Abreu, R.A.2    Bokkerink, J.P.3    Trijbels, J.M.4
  • 72
    • 0021984080 scopus 로고
    • A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells
    • Lavi LE, Holcenberg JS. A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. Anal Biochem 1985;144:514-521.
    • (1985) Anal Biochem , vol.144 , pp. 514-521
    • Lavi, L.E.1    Holcenberg, J.S.2
  • 73
    • 0037305373 scopus 로고    scopus 로고
    • Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods
    • Shipkova M, Armstrong VW, Wieland E, Oellerich M. Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods. Clin Chem 2003;49:260-268.
    • (2003) Clin Chem , vol.49 , pp. 260-268
    • Shipkova, M.1    Armstrong, V.W.2    Wieland, E.3    Oellerich, M.4
  • 74
    • 0026465403 scopus 로고
    • High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992;583:83-90.
    • (1992) J Chromatogr , vol.583 , pp. 83-90
    • Lennard, L.1    Singleton, H.J.2
  • 75
    • 0023588197 scopus 로고
    • Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells
    • Lennard L. Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells. J Chromatogr 1987;423:169-178.
    • (1987) J Chromatogr , vol.423 , pp. 169-178
    • Lennard, L.1
  • 76
    • 0031889642 scopus 로고    scopus 로고
    • Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC
    • Dervieux T, Boulieu R. Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC. Clin Chem 1998;44:551-555.
    • (1998) Clin Chem , vol.44 , pp. 551-555
    • Dervieux, T.1    Boulieu, R.2
  • 77
    • 0024822385 scopus 로고
    • Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography
    • Bruunshuus I, Schmiegelow K. Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography. Scand J Clin Lab Invest 1989;49:779-784.
    • (1989) Scand J Clin Lab Invest , vol.49 , pp. 779-784
    • Bruunshuus, I.1    Schmiegelow, K.2
  • 78
    • 0029587636 scopus 로고
    • HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients
    • Weller S, Thurmann P, Rietbrock N, Gossmann J, Scheuermann EH. HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients. Int J Clin Pharmacol Ther 1995;33:639-645.
    • (1995) Int J Clin Pharmacol Ther , vol.33 , pp. 639-645
    • Weller, S.1    Thurmann, P.2    Rietbrock, N.3    Gossmann, J.4    Scheuermann, E.H.5
  • 79
    • 0032566771 scopus 로고    scopus 로고
    • Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample
    • Mawatari H, Kato Y, Nishimura S, Sakura N, Ueda K. Reversed-phase high-performance liquid chromatographic assay method for quantitating 6-mercaptopurine and its methylated and non-methylated metabolites in a single sample. J Chromatogr B Biomed Sci Appl 1998;716:392-396.
    • (1998) J Chromatogr B Biomed Sci Appl , vol.716 , pp. 392-396
    • Mawatari, H.1    Kato, Y.2    Nishimura, S.3    Sakura, N.4    Ueda, K.5
  • 80
    • 0034771188 scopus 로고    scopus 로고
    • Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
    • Lowry PW, Franklin CL, Weaver AL, Pike MG, Mays DC, Tremaine WJ, et al. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut 2001;49:665-670.
    • (2001) Gut , vol.49 , pp. 665-670
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3    Pike, M.G.4    Mays, D.C.5    Tremaine, W.J.6
  • 81
    • 0025148411 scopus 로고
    • A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy
    • Erdmann GR, France LA, Bostrom BC, Canafax DM. A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy. Biomed Chromatogr 1990;4:47-51.
    • (1990) Biomed Chromatogr , vol.4 , pp. 47-51
    • Erdmann, G.R.1    France, L.A.2    Bostrom, B.C.3    Canafax, D.M.4
  • 82
    • 0031423967 scopus 로고    scopus 로고
    • Pharmacokinetics of mercaptopurine: Plasma drug and red cell metabolite concentrations after an oral dose
    • Welch J, Lennard L, Morton GC, Lilleyman JS. Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose. Ther Drug Monit 1997;19:382-385.
    • (1997) Ther Drug Monit , vol.19 , pp. 382-385
    • Welch, J.1    Lennard, L.2    Morton, G.C.3    Lilleyman, J.S.4
  • 83
    • 0017880983 scopus 로고
    • Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
    • Weinshilboum RM, Raymond FA, Pazmino PA. Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 1978;85:323-333.
    • (1978) Clin Chim Acta , vol.85 , pp. 323-333
    • Weinshilboum, R.M.1    Raymond, F.A.2    Pazmino, P.A.3
  • 84
    • 0037172935 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity: New conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation
    • Anglicheau D, Sanquer S, Loriot MA, Beaune P, Thervet E. Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation. J Chromatogr B Analyt Technol Biomed Life Sci 2002;773:119-127.
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci , vol.773 , pp. 119-127
    • Anglicheau, D.1    Sanquer, S.2    Loriot, M.A.3    Beaune, P.4    Thervet, E.5
  • 85
    • 0034814792 scopus 로고    scopus 로고
    • Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: Comparison with the radiochemical method
    • Menor C, Fueyo JA, Escribano O, Cara C, Fernandez-Moreno MD, Roman ID, et al. Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method. Ther Drug Monit 2001;23:536-541.
    • (2001) Ther Drug Monit , vol.23 , pp. 536-541
    • Menor, C.1    Fueyo, J.A.2    Escribano, O.3    Cara, C.4    Fernandez-Moreno, M.D.5    Roman, I.D.6
  • 86
    • 0028073102 scopus 로고
    • High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity. J Chromatogr B Biomed Appl 1994;661:25-33.
    • (1994) J Chromatogr B Biomed Appl , vol.661 , pp. 25-33
    • Lennard, L.1    Singleton, H.J.2
  • 87
    • 0035043156 scopus 로고    scopus 로고
    • Phenotype determination of thiopurine methyltransferase in erythrocytes by HPLC
    • Boulieu R, Sauviat M, Dervieux T, Bertocchi M, Mornex JF. Phenotype determination of thiopurine methyltransferase in erythrocytes by HPLC. Clin Chem 2001;47:956-958.
    • (2001) Clin Chem , vol.47 , pp. 956-958
    • Boulieu, R.1    Sauviat, M.2    Dervieux, T.3    Bertocchi, M.4    Mornex, J.F.5
  • 88
    • 0038192938 scopus 로고    scopus 로고
    • A simple high-performance liquid chromatographic method for determination of thiopurine methyltransferase activity in erythrocytes
    • Abstract
    • Indjova D, Shipkova M, Niedmann PD, Svinarov DA, Oellerich M. A simple high-performance liquid chromatographic method for determination of thiopurine methyltransferase activity in erythrocytes. J Lab Med 2002;9/10:521-522 (Abstract).
    • (2002) J Lab Med , vol.9-10 , pp. 521-522
    • Indjova, D.1    Shipkova, M.2    Niedmann, P.D.3    Svinarov, D.A.4    Oellerich, M.5
  • 89
    • 0031863222 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase activity in human erythrocytes: A new HPLC method using 6-thioguanine as substrate
    • Kroplin T, Weyer N, Gutsche S, Iven H. Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate. Eur J Clin Pharmacol 1998;54:265-271.
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 265-271
    • Kroplin, T.1    Weyer, N.2    Gutsche, S.3    Iven, H.4
  • 90
    • 0033924642 scopus 로고    scopus 로고
    • Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S-methyltransferase. A comparison of activity in red blood cell samples of 199 blood donors
    • Kroplin T, Iven H. Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S-methyltransferase. A comparison of activity in red blood cell samples of 199 blood donors. Eur J Clin Pharmacol 2000;56:343-345.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 343-345
    • Kroplin, T.1    Iven, H.2
  • 91
    • 0242640306 scopus 로고    scopus 로고
    • Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: A factor for differing results of TPMT measurements
    • Kroplin T, Fischer C, Iven H. Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements. Eur J Clin Pharmacol 1999;55:285-291.
    • (1999) Eur J Clin Pharmacol , vol.55 , pp. 285-291
    • Kroplin, T.1    Fischer, C.2    Iven, H.3
  • 92
    • 0036076821 scopus 로고    scopus 로고
    • TPMT in the treatment of Crohn's disease with azathioprine
    • Lennard L. TPMT in the treatment of Crohn's disease with azathioprine. Gut 2002;51:143-146.
    • (2002) Gut , vol.51 , pp. 143-146
    • Lennard, L.1
  • 93
    • 0030934850 scopus 로고    scopus 로고
    • Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
    • Yates CR, Krynetski EY, Loennechen T, Fessing MY, Tai HL, Pui CH, et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med 1997;126:608-614.
    • (1997) Ann Intern Med , vol.126 , pp. 608-614
    • Yates, C.R.1    Krynetski, E.Y.2    Loennechen, T.3    Fessing, M.Y.4    Tai, H.L.5    Pui, C.H.6
  • 94
    • 0034745462 scopus 로고    scopus 로고
    • High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC
    • Schaeffeler E, Lang T, Zanger UM, Eichelbaum M, Schwab M. High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC. Clin Chem 2001;47:548-555.
    • (2001) Clin Chem , vol.47 , pp. 548-555
    • Schaeffeler, E.1    Lang, T.2    Zanger, U.M.3    Eichelbaum, M.4    Schwab, M.5
  • 95
    • 0033762202 scopus 로고    scopus 로고
    • Genotyping of eight thiopurine methyltransferase mutations: Three-color multiplexing, 'two-color/shared' anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design
    • Schütz E, von Ahsen N, Oellerich M. Genotyping of eight thiopurine methyltransferase mutations: three-color multiplexing, 'two-color/shared' anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design. Clin Chem 2000;46:1728-1737.
    • (2000) Clin Chem , vol.46 , pp. 1728-1737
    • Schütz, E.1    Von Ahsen, N.2    Oellerich, M.3
  • 97
    • 0036216741 scopus 로고    scopus 로고
    • Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation
    • McDonald OG, Krynetski EY, Evans WE. Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation. Pharmacogenetics 2002;12:93-99.
    • (2002) Pharmacogenetics , vol.12 , pp. 93-99
    • McDonald, O.G.1    Krynetski, E.Y.2    Evans, W.E.3
  • 98
    • 0038531583 scopus 로고    scopus 로고
    • Thiopurine methyl transferase (TPMT) *3A, *3B and *3C haplotyping by combined long range PCR, intramolecular ligation and real time ASA-PCR
    • Abstract
    • von Ahsen N, Schütz E, Hartung S, Andag R, Oellerich M. Thiopurine methyl transferase (TPMT) *3A, *3B and *3C haplotyping by combined long range PCR, intramolecular ligation and real time ASA-PCR. J Lab Med 2002;26:522 (Abstract).
    • (2002) J Lab Med , vol.26 , pp. 522
    • Von Ahsen, N.1    Schütz, E.2    Hartung, S.3    Andag, R.4    Oellerich, M.5


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