Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene [1]

Leukemia

Volumn 15, Issue 11, 2001, Pages 1792-1793

  Brouwer, C ^a   Marinaki, A M ^b   Lambooy, L H J ^a   Duley, J A ^b   Shobowale Bakre, M ^b   De Abreu, R A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; CHILD; CONTROLLED STUDY; DIAGNOSTIC ERROR; EXON; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCREENING;

EID: 0035171564     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402285     Document Type: Letter

References (9)

1. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
2. Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
3. Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
4. Screening for azathioprine toxicity: A pharmacoeconomic analysis based on a target case
5. Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls
6. Thiopurine methyltransferase polymorphic tandem repeat: Genotype-phenotype correlation analysis
7. Genotyping of eight thiopurine methyltransferase mutations: Three-color multiplexing, 'two-color/shared' anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design
8. Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
9. *2): Mechanisms for the genetic polymorphism of TPMT activity