Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease

Gut

Volumn 49, Issue 5, 2001, Pages 665-670

  Lowry, P W ^a   Franklin, C L ^a   Weaver, A L ^a   Gennett Pike, M ^a   Mays, D C ^a   Tremaine, W J ^a   Lipsky, J J ^a   Sandborn, W J ^a  

^a MAYO CLINIC   (United States)

Author keywords

6 mercaptopurine; Azathioprine; Inflammatory bowel disease; Thioguanine nucleotides; Thiopurine methyltransferase

Indexed keywords

AZATHIOPRINE; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE;

ADULT; AGED; ARTICLE; BLOOD; CONTROLLED STUDY; DISEASE ACTIVITY; DOSE RESPONSE; DRUG TOLERABILITY; ENTERITIS; ENZYME ACTIVITY; FEMALE; HUMAN; LEUKOCYTE COUNT; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PRIORITY JOURNAL; REMISSION;

6-MERCAPTOPURINE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AZATHIOPRINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; LEUKOPENIA; MALE; METHYLTRANSFERASES; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 0034771188     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.49.5.665     Document Type: Article

References (22)

1. Azathioprine and 6-mercaptopurine in Crohn's disease. A meta-analysis
2. The long-term outcome of ulcerative colitis treated with 6-mercaptopurine
3. The clinical pharmacology of 6-mercaptopurine
4. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
5. Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
6. Patterns of azathioprine metabolites in neutrophils, lymphocytes, reticulocytes, and erythrocytes: Relevance to toxicty and monitoring in recipients of renal allografts
7. Childhood leukemia: A relationship between intracellular 6-mercapatopurine metabolites and neutropenia
8. 6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity
9. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
10. Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide
11. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease
12. Mercaptopurine metabolism and the risk of relapse in childhood lymphoblastic leukaemia
13. Quality of life: A valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease
14. Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
15. A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguaine, and methylmercaptopurine in a patient receiving thiopurine therapy
16. The influence of multiple oral doses of zileuton on the steady-state pharmacokinetics of sulfasalazine and its metabolites, sulfapyridine and N-acetylsulfapyridine
17. Effect of food coadministration on 5-aminosalicylic acid oral suspension bioavailability
18. High-performance liquid chromatographic assay for the determination of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid concentrations in endoscopic intestinal biopsy in humans
19. Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine, and 6-thioguanne, in human red blood cells
20. Sulphasalazine inhibition of thiopurine methyltransferase: Possible mechanism for interaction with 6-mercaptopurine and azathioprine
21. Balsalazide and azathioprine or 6-mercaptopurine: Evidence for a potentially serious drug interaction
22. Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug interaction