-
1
-
-
0026588527
-
Human hepatic microsomal thiol methyltransferase: Assay conditions, biochemical properties and correlation studies
-
Glauser TA, Kerremans AL, Weinshilboum RM. Human hepatic microsomal thiol methyltransferase: assay conditions, biochemical properties and correlation studies. Drug Metab Dispos 1992;20: 247-55.
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 247-255
-
-
Glauser, T.A.1
Kerremans, A.L.2
Weinshilboum, R.M.3
-
2
-
-
0028000052
-
Purine substrates for human thiopurine methyltransferase
-
Deininger M, Szumlanski CL, Otterness DM, van Loon J, Ferber W, Weinshilboum RM. Purine substrates for human thiopurine methyltransferase. Biochem Pharmacol 1994;11:2135-8.
-
(1994)
Biochem Pharmacol
, vol.11
, pp. 2135-2138
-
-
Deininger, M.1
Szumlanski, C.L.2
Otterness, D.M.3
Van Loon, J.4
Ferber, W.5
Weinshilboum, R.M.6
-
3
-
-
0021052544
-
Thiopurine methyltransferase: Aromatic thiol substrates and inhibition by benzoic acid derivatives
-
Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM. Thiopurine methyltransferase: aromatic thiol substrates and inhibition by benzoic acid derivatives. Mol Pharmacol 1983;24: 471-8.
-
(1983)
Mol Pharmacol
, vol.24
, pp. 471-478
-
-
Woodson, L.C.1
Ames, M.M.2
Selassie, C.D.3
Hansch, C.4
Weinshilboum, R.M.5
-
4
-
-
0028269944
-
6-Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia
-
Lilleyman JS, Lennard L. 6-Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia. Lancet 1994; 343:1188-90.
-
(1994)
Lancet
, vol.343
, pp. 1188-1190
-
-
Lilleyman, J.S.1
Lennard, L.2
-
5
-
-
0025331198
-
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
-
Lennard L, Lilleyman JS, Van Loon JA, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990;336:225-9.
-
(1990)
Lancet
, vol.336
, pp. 225-229
-
-
Lennard, L.1
Lilleyman, J.S.2
Van Loon, J.A.3
Weinshilboum, R.M.4
-
6
-
-
0027524983
-
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
-
Lennard L, Gibson BES, Nicole T, Lilleyman JS. Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child 1993;69:577-9.
-
(1993)
Arch Dis Child
, vol.69
, pp. 577-579
-
-
Lennard, L.1
Gibson, B.E.S.2
Nicole, T.3
Lilleyman, J.S.4
-
7
-
-
0030802914
-
Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-Mercaptopurine dosage strategies
-
Lennard L, Lewis IJ, Michelagnoli M, Lilleyman JS. Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-Mercaptopurine dosage strategies. Med Pediatr Oncol 1997;29:252-5.
-
(1997)
Med Pediatr Oncol
, vol.29
, pp. 252-255
-
-
Lennard, L.1
Lewis, I.J.2
Michelagnoli, M.3
Lilleyman, J.S.4
-
8
-
-
0028930908
-
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with ALL
-
McLeod HL, Relling MV, Liu Q, Pui C-H, Evans WE. Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with ALL. Blood 1995; 7:1897-1902.
-
(1995)
Blood
, vol.7
, pp. 1897-1902
-
-
McLeod, H.L.1
Relling, M.V.2
Liu, Q.3
Pui, C.-H.4
Evans, W.E.5
-
9
-
-
0030656430
-
Thiopurine drugs in the treatment of childhood leukaemia: The influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity
-
Lennard L, Welch J, Lilleyman JS. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br J Clin Pharmacol 1997;44:455-61.
-
(1997)
Br J Clin Pharmacol
, vol.44
, pp. 455-461
-
-
Lennard, L.1
Welch, J.2
Lilleyman, J.S.3
-
10
-
-
0021183237
-
Severe megaloblastic leukaemia associated with abnormal azathioprine metabolism
-
Lennard L, Murphy MF, Maddocks JL. Severe megaloblastic leukaemia associated with abnormal azathioprine metabolism. Br J Clin Pharmacol 1984;17:171-2.
-
(1984)
Br J Clin Pharmacol
, vol.17
, pp. 171-172
-
-
Lennard, L.1
Murphy, M.F.2
Maddocks, J.L.3
-
11
-
-
0024451147
-
Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
-
Lennard L, Van Loon JA, Weinshilboum RM. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989;46: 149-54.
-
(1989)
Clin Pharmacol Ther
, vol.46
, pp. 149-154
-
-
Lennard, L.1
Van Loon, J.A.2
Weinshilboum, R.M.3
-
12
-
-
0025837127
-
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase deficient child with acute lymphoblastic leukaemia
-
Evans WE, Horner M, Chu YQ, Kalwinsky D, Roberts VM. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase deficient child with acute lymphoblastic leukaemia. J Pediatr 1991;119:985-9.
-
(1991)
J Pediatr
, vol.119
, pp. 985-989
-
-
Evans, W.E.1
Horner, M.2
Chu, Y.Q.3
Kalwinsky, D.4
Roberts, V.M.5
-
13
-
-
0028815315
-
Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation
-
Schutz E, Gummert J, Mohr F, Armstrong VW, Oellerich M. Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation. Transplant Proc 1995;27:1298-1300.
-
(1995)
Transplant Proc
, vol.27
, pp. 1298-1300
-
-
Schutz, E.1
Gummert, J.2
Mohr, F.3
Armstrong, V.W.4
Oellerich, M.5
-
14
-
-
0026443183
-
Pancytopenia related to azathioprine - An enzyme deficiency caused by a common genetic polymorphism: A review
-
Anstey A, Lennard L, Mayou SC, Kirby JD. Pancytopenia related to azathioprine - an enzyme deficiency caused by a common genetic polymorphism: a review. J R Soc Med 1992;85:752-6.
-
(1992)
J R Soc Med
, vol.85
, pp. 752-756
-
-
Anstey, A.1
Lennard, L.2
Mayou, S.C.3
Kirby, J.D.4
-
15
-
-
0018822866
-
Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
-
Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980;32:651-62.
-
(1980)
Am J Hum Genet
, vol.32
, pp. 651-662
-
-
Weinshilboum, R.M.1
Sladek, S.L.2
-
16
-
-
0026714550
-
Methylation pharmacogenetics: Thiopurine methyltransferase as a model system
-
Weinshilboum RM. Methylation pharmacogenetics: thiopurine methyltransferase as a model system. Xenobiotica 1992;22:1055-71.
-
(1992)
Xenobiotica
, vol.22
, pp. 1055-1071
-
-
Weinshilboum, R.M.1
-
17
-
-
0027410849
-
Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population
-
Klemetsdal B, Straume B, Wist E, Aarbakke J. Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population. Eur J Clin Pharmacol 1993;44:147-52.
-
(1993)
Eur J Clin Pharmacol
, vol.44
, pp. 147-152
-
-
Klemetsdal, B.1
Straume, B.2
Wist, E.3
Aarbakke, J.4
-
18
-
-
0028044714
-
Thiopurine methyltransferase activity in American white subjects and black subjects
-
McLeod HL, Lin J-S, Scott EP, Pui C-H, Evans WE. Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharm Ther 1994;55:15-20.
-
(1994)
Clin Pharm Ther
, vol.55
, pp. 15-20
-
-
McLeod, H.L.1
Lin, J.-S.2
Scott, E.P.3
Pui, C.-H.4
Evans, W.E.5
-
19
-
-
0029759012
-
Thiopurine emthyltransferase activity in a Korean population sample of children
-
Park-Hah JO, Klementsdal B, Lyssa R, Choi KH, Aarbakke J. Thiopurine emthyltransferase activity in a Korean population sample of children. Clin Pharmacol Ther 1996;60:68-74.
-
(1996)
Clin Pharmacol Ther
, vol.60
, pp. 68-74
-
-
Park-Hah, J.O.1
Klementsdal, B.2
Lyssa, R.3
Choi, K.H.4
Aarbakke, J.5
-
20
-
-
0026907122
-
Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
-
Szumlanski CL, Honchel R, Scott MC, Weinshilboum RM. Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1982;2:148-59.
-
(1982)
Pharmacogenetics
, vol.2
, pp. 148-159
-
-
Szumlanski, C.L.1
Honchel, R.2
Scott, M.C.3
Weinshilboum, R.M.4
-
21
-
-
0026543630
-
Interethnic differences in thiopurine methyltransferase activity
-
Klemetsdal B, Tollefsen E, Loennechen T, et al. Interethnic differences in thiopurine methyltransferase activity. Clin Pharmacol Ther 1992;51:24-31.
-
(1992)
Clin Pharmacol Ther
, vol.51
, pp. 24-31
-
-
Klemetsdal, B.1
Tollefsen, E.2
Loennechen, T.3
-
22
-
-
0028913757
-
Thiopurine methyltransferase pharmacogenetics: Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1
-
Lee D, Szumlanski C, Houtman J, et al. Thiopurine methyltransferase pharmacogenetics: cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1. Drug Metab Dispos 1995;23:398-405.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 398-405
-
-
Lee, D.1
Szumlanski, C.2
Houtman, J.3
-
23
-
-
0030048791
-
Thiopurine methyltransferase pharmacogenetics: Human gene cloning and characterization of a common polymorphism
-
Szumlanski C, Otterness D, Her C, et al. Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism. DNA Cell Biol 1996;15:17-30.
-
(1996)
DNA Cell Biol
, vol.15
, pp. 17-30
-
-
Szumlanski, C.1
Otterness, D.2
Her, C.3
-
24
-
-
12644291917
-
Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms
-
Otterness D, Szumlanski C, Lennard L, et al. Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms. Clin Pharmacol Ther 1997;62:60-73.
-
(1997)
Clin Pharmacol Ther
, vol.62
, pp. 60-73
-
-
Otterness, D.1
Szumlanski, C.2
Lennard, L.3
-
25
-
-
0030934850
-
Molecular basis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance
-
Yates CR, Krynetski EY, Loennechen T, et al. Molecular basis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann Intern Med 1997; 126:608-14.
-
(1997)
Ann Intern Med
, vol.126
, pp. 608-614
-
-
Yates, C.R.1
Krynetski, E.Y.2
Loennechen, T.3
-
26
-
-
0030986251
-
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
-
Tai H-L, Krynetski EY, Schuetz EG, Yanishevski Y, Evans WE. Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci 1997;94:6444-9.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 6444-6449
-
-
Tai, H.-L.1
Krynetski, E.Y.2
Schuetz, E.G.3
Yanishevski, Y.4
Evans, W.E.5
-
27
-
-
0030011484
-
Intraindividual variability in red blood cell thiopurine methyltransferase activity
-
Giverhaug T, Klemetsdal B, Lysaa, Aarbakke J. Intraindividual variability in red blood cell thiopurine methyltransferase activity. Eur J Clin Pharmacol 1996;50:217-20.
-
(1996)
Eur J Clin Pharmacol
, vol.50
, pp. 217-220
-
-
Giverhaug, T.1
Klemetsdal, B.2
Lysaa3
Aarbakke, J.4
-
28
-
-
0030027378
-
Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide
-
Lysaa RA, Giverhaug T, Wold HL, Aarbakke J. Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol 1996;49:393-6.
-
(1996)
Eur J Clin Pharmacol
, vol.49
, pp. 393-396
-
-
Lysaa, R.A.1
Giverhaug, T.2
Wold, H.L.3
Aarbakke, J.4
-
29
-
-
0018939350
-
Thiol S-methylation in ureamia: Erythrocyte enzyme activities and plasma inhibitors
-
Pazmino PA, Sladek SL, Weinshilboum RM. Thiol S-methylation in ureamia: erythrocyte enzyme activities and plasma inhibitors. Clin Pharmacol Ther 1980;28:356-67.
-
(1980)
Clin Pharmacol Ther
, vol.28
, pp. 356-367
-
-
Pazmino, P.A.1
Sladek, S.L.2
Weinshilboum, R.M.3
-
30
-
-
0027420842
-
Diethylthiocarbamate S-methylation: Evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase
-
Glauser TA, Nelson MD, Zembower DE, Lipsky JJ, Weinshilboum RM. Diethylthiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase. J Pharmacol Exp Ther 1993;266:23-32.
-
(1993)
J Pharmacol Exp Ther
, vol.266
, pp. 23-32
-
-
Glauser, T.A.1
Nelson, M.D.2
Zembower, D.E.3
Lipsky, J.J.4
Weinshilboum, R.M.5
-
31
-
-
0028917479
-
Sulfsalazine inhibition of thiopurine methyltransferase: Possible mechanism for interaction with 6-mercaptopurine and azathioprine
-
Szumlanski C, Weinshilboum RM. Sulfsalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol 1995;39: 456-9.
-
(1995)
Br J Clin Pharmacol
, vol.39
, pp. 456-459
-
-
Szumlanski, C.1
Weinshilboum, R.M.2
-
32
-
-
0018888679
-
Treatment of Crohn's disease with 6-mercaptopurine: A long-term randomized double blind study
-
Present DH, Korelitz BI, Wisch N, Glass JL, Sacher DB, Pasternack BS. Treatment of Crohn's disease with 6-mercaptopurine: a long-term randomized double blind study. N Engl J Med 1980; 302:981-7.
-
(1980)
N Engl J Med
, vol.302
, pp. 981-987
-
-
Present, D.H.1
Korelitz, B.I.2
Wisch, N.3
Glass, J.L.4
Sacher, D.B.5
Pasternack, B.S.6
-
33
-
-
0030657957
-
Olsalazine and 6-mercaptopurine-related bone marrow, suppression: A possible drug-drug interaction
-
Lewis LD, Benin A, Szumlanski CL, et al. Olsalazine and 6-mercaptopurine-related bone marrow, suppression: a possible drug-drug interaction. Clin Pharmacol Ther 1997;62:464-75.
-
(1997)
Clin Pharmacol Ther
, vol.62
, pp. 464-475
-
-
Lewis, L.D.1
Benin, A.2
Szumlanski, C.L.3
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